Results 21 to 30 of about 23,223 (305)

Recent advances of nanobody applications in diagnosis and detection

MedComm – Biomaterials and Applications, 2023
Nanobodies (Nbs) are the variable domain of heavy‐chain antibodies derived from the blood of camelids or sharks. Nanobodies are the smallest antibody fragment with intact antigen‐binding ability.
Qianling Su, Wei Shi, Xianing Huang, Shihua Yin, Xiaomei Yang, Xiaoling Lu   +5 more
doaj   +1 more source

Nanobody-dependent delocalization of endocytic machinery in Arabidopsis root cells dampens their internalization capacity [PDF]

, 2020
Plant cells perceive and adapt to an ever-changing environment by modifying their plasma membrane (PM) proteome. Whereas secretion deposits new integral membrane proteins, internalization by endocytosis removes membrane proteins and associated ligands ...
De Meyer, Andreas, Grones, Peter, Mylle, Evelien, Van Damme, Daniël, Winkler, Joanna   +4 more
core   +2 more sources

Nanobody mediated inhibition of attachment of F18 fimbriae expressing Escherichia coli [PDF]

, 2014
Post-weaning diarrhea and edema disease caused by F18 fimbriated E. coli are important diseases in newly weaned piglets and lead to severe production losses in farming industry.
Coddens, Annelies, Cox, Eric, De Greve, Henri, De Kerpel, Maia, Moonens, Kristof, Pardon, Els, Remaut, Han   +6 more
core   +8 more sources

Immunogenicity Risk Profile of Nanobodies [PDF]

Frontiers in Immunology, 2021
Nanobodies (Nbs), the variable domains of camelid heavy chain-only antibodies, are a promising class of therapeutics or in vivo imaging reagents entering the clinic. They possess unique characteristics, including a minimal size, providing fast pharmacokinetics, high-target specificity, and an affinity in the (sub-)nanomolar range in conjunction with an
Chloé Ackaert, Natalia Smiejkowska, Catarina Xavier, Yann G. J. Sterckx, Yann G. J. Sterckx, Sofie Denies, Benoit Stijlemans, Benoit Stijlemans, Yvon Elkrim, Nick Devoogdt, Vicky Caveliers, Vicky Caveliers, Tony Lahoutte, Tony Lahoutte, Serge Muyldermans, Karine Breckpot, Marleen Keyaerts, Marleen Keyaerts   +17 more
openaire   +5 more sources

Single-Domain Antibody-Based TCR-Like CAR-T: A Potential Cancer Therapy

Journal of Immunology Research, 2020
Retargeting the antigen-binding specificity of T cells to intracellular antigens that are degraded and presented on the tumor surface by engineering chimeric antigen receptor (CAR), also named TCR-like antibody CAR-T, remains limited.
Lichen Zhu, Xiaomei Yang, Dani Zhong, Shenxia Xie, Wei Shi, Yangzi Li, Xiaoqiong Hou, HuaYao, Huihui Zhou, Minlong Zhao, Ziqiang Ding, Xinyue Zhao, Fengzhen Mo, Shihua Yin, Aiqun Liu, Xiaoling Lu   +15 more
doaj   +1 more source

Nanobody-Targeted Photodynamic Therapy: Nanobody Production and Purification

, 2022
Nanobodies have recently been introduced to the field of photodynamic therapy (PDT) as a very promising strategy to target photosensitizers selectively to cancer cells. Nanobodies are known for their characteristic small size (15 kDa), high specificity, and high binding affinities.
Mashayekhi, Vida, Schooten, Erik, van Bergen En Henegouwen, Paul M P, Kijanka, Marta M, Oliveira, Sabrina   +4 more
openaire   +4 more sources

Chemogenetic Control of Nanobodies [PDF]

Nature Methods, 2019
ABSTRACTWe introduce an engineered nanobody whose affinity to green fluorescent protein (GFP) can be switched on and off with small molecules. By controlling the cellular localization of GFP fusion proteins, the engineered nanobody allows to study their role in basic biological processes, an approach that should be applicable to numerous previously ...
Farrants, Helen, Tarnawski, Miroslaw, Müller, Thorsten G., Otsuka, Shotaro, Hiblot, Julien, Koch, Birgit, Kueblbeck, Moritz, Kräusslich, Hans-Georg, Ellenberg, Jan, Johnsson, Kai   +9 more
openaire   +3 more sources

Description of a nanobody-based competitive immunoassay to detect tsetse fly exposure [PDF]

, 2015
Background : Tsetse flies are the main vectors of human and animal African trypanosomes. The Tsal proteins in tsetse fly saliva were previously identified as suitable biomarkers of bite exposure.
Caljon, Guy, Hussain, Shahid, Van Den Abbeele, Jan, Vermeiren, Lieve   +3 more
core   +5 more sources

Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice

Communications Medicine, 2022
Nagata, Utsumi, Asaka, Maeda et al. describe a nanobody, TP86, that potently neutralizes both BA.1 and BA.2 Omicron SARS-CoV-2 variants, and, when combined with the TP17 nanobody, broadly neutralizes all SARS-CoV-2 variants.
Kayoko Nagata, Daichi Utsumi, Masamitsu N. Asaka, Ryota Maeda, Kotaro Shirakawa, Yasuhiro Kazuma, Ryosuke Nomura, Yoshihito Horisawa, Yohei Yanagida, Yugo Kawai, Kei Sato, Yutaro Yamaoka, Kei Miyakawa, Akihide Ryo, Yasuhiro Yasutomi, Akihiro Imura, Akifumi Takaori-Kondo   +16 more
doaj   +1 more source

Improved detection of molecular markers of atherosclerotic plaques using sub-millimeter PET imaging [PDF]

, 2020
Since atherosclerotic plaques are small and sparse, their non-invasive detection via PET imaging requires both highly specific radiotracers as well as imaging systems with high sensitivity and resolution.
Bormans, Guy, Bridoux, Jessica, Broisat, Alexis, Caveliers, Vicky, Cleeren, Frederik, Debie, Pieterjan, Descamps, Benedicte, Devoogdt, Nick, Hernot, Sophie, Neyt, Sara, Vanhove, Christian, Xavier, Catarina   +11 more
core   +2 more sources