Results 31 to 40 of about 23,223 (305)
Nanobodies that Neutralize HIV [PDF]
Vaccines, 2019 Nanobodies or VHH (variable domains of heavy-chain only antibodies) are derived from camelid species such as llamas and camels. Nanobodies isolated and selected through phage display can neutralize a broad range of human immunodeficiency virus type 1 (HIV-1) strains.
Robin A. Weiss, C. Theo Verrips
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Nanobodies as molecular imaging probes
Free Radical Biology and Medicine, 2022 Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies (Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their desirable properties such as small size, high specificity, strong affinity, excellent stability, and modularity, nanobodies are on their way to overtake conventional antibodies in
Sarah Barakat +4 more
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Journal of Pharmaceutical Analysis, 2022 Recombinant human interferon α2b (rhIFNα2b) is widely used as an antiviral therapy agent for the treatment of hepatitis B and hepatitis C. The current identification test for rhIFNα2b is complex.
Xi Qin +15 more
doaj +1 more source
Scientific Reports, 2021 A fusion protein comprising an antibody and a cationic peptide, such as arginine-9 (R9), is a candidate molecule for efficient and cell-specific delivery of siRNA into cells in order to reduce the side effects of nucleic acid drugs.
Yu Ando +4 more
doaj +1 more source
Functional characterization and discovery of modulators of SbMATE, the agronomically important aluminium tolerance transporter from Sorghum bicolor. [PDF]
, 2017 About 50% of the world's arable land is strongly acidic (pH ≤ 5). The low pH solubilizes root-toxic ionic aluminium (Al3+) species from clay minerals, driving the evolution of counteractive adaptations in cultivated crops.
Chang, Geoffrey +6 more
core +3 more sources
Exploring cellular biochemistry with nanobodies [PDF]
Journal of Biological Chemistry, 2020 Reagents that bind tightly and specifically to biomolecules of interest remain essential in the exploration of biology and in their ultimate application to medicine. Besides ligands for receptors of known specificity, agents commonly used for this purpose are monoclonal antibodies derived from mice, rabbits, and other animals.
Cheloha, Ross W +4 more
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Diversity in kinetics correlated with structure in nano body-stabilized LacY.
PLoS ONE, 2020 The structure of lactose permease, stabilized in a periplasmic open conformation by two Gly to Trp replacements (LacYww) and complexed with a nanobody directed against this conformation, provides the highest resolution structure of the symporter.
Hemant Kumar +7 more
doaj +1 more source
Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3) [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): As T-cell immunoglobulin and mucin domain 3 (TIM-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition.
Vida Homayouni +5 more
doaj +1 more source
Penetration of Nanobody-Dextran Polymer Conjugates through Tumor Spheroids
Pharmaceutics, 2023 Here we report the generation of nanobody dextran polymer conjugates (dextraknobs) that are loaded with small molecules, i.e., fluorophores or photosensitizers, for potential applications in cancer diagnostics and therapy.
Peter Bitsch +6 more
doaj +1 more source
Identification and characterization of nanobodies targeting the EphA4 receptor [PDF]
, 2017 The ephrin receptor A4 (EphA4) is one of the receptors in the ephrin system that plays a pivotal role in a variety of cell-cell interactions, mostly studied during development. In addition, EphA4 has been found to play a role in cancer biology as well as
Chavez-Gutierrez, Lucia +16 more
core +2 more sources