Results 51 to 60 of about 23,223 (305)

Spontaneous emission rate of an excited atom placed near a nanofiber

, 2002
The spontaneous decay rates of an excited atom placed near a dielectric cylinder are investigated. A special attention is paid to the case when the cylinder radius is small in comparison with radiation wavelength (nanofiber or photonic wire).
't Hooft, Braginsky, Braginsky, Bykov, Chance, Chew, Collot, Fermi, Goy, Jhe, John, Klimov, Klimov, Klimov, Kocharovsky, Lagarkov, Lin, Mie, Pendry, Purcell, Sandoghdar, Shelby, Shelby, Smith, Smith, V.V. Klimov, Veselago, Yablonovich   +27 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist [PDF]

, 2020
The kappa opioid receptor (κOR) is an important target for pain therapeutics to reduce depression and other harmful side effects of existing medications.
Goddard, William A., III, Kim, Soo-Kyung, Mafi, Amirhossein   +2 more
core   +1 more source

Single-domain antibodies and their formatting to combat viral infections [PDF]

, 2018
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies, De Vlieger, Dorien, Rossey, Iebe, Saelens, Xavier, Schepens, Bert   +4 more
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

A nanobody-guided multifunctional T cell engager promotes strong anti-tumor responses via synergistic immuno-photothermal effects

Journal of Nanobiotechnology
Background T cell-based immunotherapies are facing great challenges in the recruitment and activation of tumor-specific T cells against solid tumors. Among which, utilizing nanobody (Nb) or nanobodies (Nbs) to construct T cell engager has emerged as a ...
Shenxia Xie, Wei Shi, Siliang Duan, Xianing Huang, Aiqun Liu, Xiaoqiong Hou, Xuandong Lin, Dani Zhong, Shuyang Sun, Ziqiang Ding, Xiaomei Yang, Xiaoyuan Chen, Xiaoling Lu   +12 more
doaj   +1 more source

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Dendritic cell vaccines: Current research progress, challenges, and opportunities

Genes and Diseases
This review examines the advancements in cancer immunotherapies, particularly focusing on dendritic cell (DC)-based vaccines developed through in vitro methods.
Shilin Zhang, Shanzhao Mo, Wenxing Huang, Dani Zhong, Xiaomei Yang, Shenxia Xie, Aiqun Liu, Fengzhen Mo, Xianing Huang, Heng Liu, Yangzi Li, Xiaoling Lu   +11 more
doaj   +1 more source

CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin

Biomaterials Research, 2022
Background It is highly desirable to develop new therapeutic strategies for gastric cancer given the low survival rate despite improvement in the past decades.
Jingbo Ma, Xiaolong Xu, Chunjin Fu, Peng Xia, Ming Tian, Liuhai Zheng, Kun Chen, Xiaolian Liu, Yilei Li, Le Yu, Qinchang Zhu, Yangyang Yu, Rongrong Fan, Haibo Jiang, Zhifen Li, Chuanbin Yang, Chengchao Xu, Ying Long, Jigang Wang, Zhijie Li   +19 more
doaj   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source