Results 41 to 50 of about 16,460 (261)
, 2022 sog-Nanobody/+;;GFP/+ embryo with maternally loaded GFP, live imaged on a confocal microscope. Movies here show Z stacks at selected time points, and show a maximum intensity projection of the full time ...
Division of Molecular & Cellular Function +1 more
core +2 more sources
Representative BLItz KD quantification of nanobody 26.
, 2023 (A) Sequential loading of five steps for Biolayer Interferometry Analysis of nanobody 26 (626.57 nM) at six concentrations of PRL-3. Baseline– 30 seconds of BLI buffer to equilibrate the biosensor; Loading– 30 seconds of nanobody incubation with ...
K. Martin Chow (772610) +7 more
core +1 more source
Frontiers in Immunology, 2017 Over the last two decades, nanobodies or single-domain antibodies have found their way in research, diagnostics, and therapy. These antigen-binding fragments, derived from Camelid heavy chain only antibodies, possess remarkable characteristics that favor
Els Beghein, Jan Gettemans
doaj +1 more source
Communications Medicine, 2022 Nagata, Utsumi, Asaka, Maeda et al. describe a nanobody, TP86, that potently neutralizes both BA.1 and BA.2 Omicron SARS-CoV-2 variants, and, when combined with the TP17 nanobody, broadly neutralizes all SARS-CoV-2 variants.
Kayoko Nagata +16 more
doaj +1 more source
Nanobodies as molecular imaging probes
Free Radical Biology and Medicine, 2022 Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies (Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their desirable properties such as small size, high specificity, strong affinity, excellent stability, and modularity, nanobodies are on their way to overtake conventional antibodies in
Sarah Barakat +4 more
openaire +4 more sources
Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3) [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): As T-cell immunoglobulin and mucin domain 3 (TIM-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition.
Vida Homayouni +5 more
doaj +1 more source
Nanobody-Mediated Neutralization Reveals an Achilles Heel for Norovirus
, 2020 Human norovirus frequently causes outbreaks of acute gastroenteritis. Although discovered more than five decades ago, antiviral development has, until recently, been hampered by the lack of a reliable human norovirus cell culture system.
Hansman, GS +5 more
core +1 more source
Scientific Reports, 2021 A fusion protein comprising an antibody and a cationic peptide, such as arginine-9 (R9), is a candidate molecule for efficient and cell-specific delivery of siRNA into cells in order to reduce the side effects of nucleic acid drugs.
Yu Ando +4 more
doaj +1 more source
INDI – Integrated Nanobody Database for Immunoinformatics [PDF]
Nucleic Acids Research, 2021 Abstract Nanobodies, a subclass of antibodies found in camelids, are a versatile molecular binding scaffold composed of a single polypeptide chain. The small size of nanobodies bestows multiple therapeutic advantages (stability, tumor penetration) with the first therapeutic approval in 2018 cementing the clinical ...
Piotr Deszynski +7 more
openaire +3 more sources
Diversity in kinetics correlated with structure in nano body-stabilized LacY.
PLoS ONE, 2020 The structure of lactose permease, stabilized in a periplasmic open conformation by two Gly to Trp replacements (LacYww) and complexed with a nanobody directed against this conformation, provides the highest resolution structure of the symporter.
Hemant Kumar +7 more
doaj +1 more source