Results 11 to 20 of about 18,503 (241)

Penetration of Nanobody-Dextran Polymer Conjugates through Tumor Spheroids [PDF]

Pharmaceutics, 2023
Here we report the generation of nanobody dextran polymer conjugates (dextraknobs) that are loaded with small molecules, i.e., fluorophores or photosensitizers, for potential applications in cancer diagnostics and therapy.
Peter Bitsch, Eva S. Baum, Irati Beltrán Hernández, Sebastian Bitsch, Jakob Harwood, Sabrina Oliveira, Harald Kolmar   +6 more
doaj   +3 more sources

Nanobody-derived nanobiotechnology tool kits for diverse biomedical and biotechnology applications

International Journal of Nanomedicine, 2016
Yongzhong Wang,1 Zhen Fan,2 Lei Shao,3 Xiaowei Kong,1 Xianjuan Hou,1 Dongrui Tian,1 Ying Sun,1 Yazhong Xiao,1 Li Yu4 1School of Life Sciences, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei, People’s Republic of
Wang Y, Fan Z, Shao L, Kong X, Hou X, Tian D, Sun Y, Xiao Y, Yu L   +8 more
doaj   +1 more source

A Novel Anti-CD47 Nanobody Tetramer for Cancer Therapy

Antibodies
CD47 acts as a defense mechanism for tumor cells by sending a “don’t eat me” signal via its bond with SIRPα. With CD47’s overexpression linked to poor cancer outcomes, its pathway has become a target in cancer immunotherapy.
Nataliya M. Ratnikova, Yulia Kravchenko, Anna Ivanova, Vladislav Zhuchkov, Elena Frolova, Stepan Chumakov   +5 more
doaj   +2 more sources

Development of an Anti-Zearalenone Nanobody Phage Display Library and Preparation of Specific Nanobodies

Current Issues in Molecular Biology
Zearalenone (ZEN), a toxic estrogenic mycotoxin in cereals, threatens human and animal health through reproductive, immune, and cytotoxic effects, necessitating sensitive detection methods.
Ying Zeng, Yiying Hu, Ganying Chen, Qingqing Feng, Ruiting Wang, Zhilin Zhang, Jinxian Chen, Junbin Liao, Danrong Lin, Wei Zhu   +9 more
doaj   +2 more sources

Antigen-Detected NMR for Minimal Epitope Engineering and Structure-Guided Selection of a Na_V1.7-Selective Nanobody. [PDF]

Adv Sci (Weinh)
A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Liu J, Chen W, Cristofori-Armstrong B, Crawford T, Chen KE, Xie P, Chan RWB, Zhu Y, Golder M, Pereira Schmidt A, Naughton JD, Condon ND, Andersson Å, Dehkhoda F, McMahon KL, Klasfauseweh T, Thapa A, Tran H, Tran P, Jami S, Ragnarsson L, Furness SGB, Deuis JR, Collins BM, Tham WH, Prasadam I, Vetter I, Mobli M.   +27 more
europepmc   +2 more sources

Nanobody-Targeted Photodynamic Therapy: Nanobody Production and Purification [PDF]

, 2022
Nanobodies have recently been introduced to the field of photodynamic therapy (PDT) as a very promising strategy to target photosensitizers selectively to cancer cells.
Kijanka, Marta M, Mashayekhi, Vida, Schooten, Erik, van Bergen En Henegouwen, Paul M P, Oliveira, Sabrina   +4 more
core   +3 more sources

Nanobody [PDF]

, 2021
Nanobodies have become outstanding tools for biomedical research, diagnostics and therapy. Recent advances in the identification and functionalization of target-specific nanobodies now make nanobody-based approaches broadly available to many researches ...

core   +2 more sources

Tyrosinase-Mediated Synthesis of Nanobody–Cell Conjugates [PDF]

, 2022
A convenient enzymatic strategy is reported for the modification of cell surfaces. Using a tyrosinase enzyme isolated from Agaricus bisporus, unique tyrosine residues introduced at the C-termini of nanobodies can be site-selectively oxidized to reactive ...
Daniel K. Nomura (198023), Johnathan C. Maza (1416832), Noah X. Hamlish (12906839), Derek M. García-Almedina (11942742), Lydia E. Boike (12906836), Matthew B. Francis (425831)   +5 more
core   +4 more sources

Nanobody-Based Bispecific Neutralizer for Shiga Toxin-Producing E.coli

, 2022
Currently, no specific therapeutics are available for foodborne Shiga toxin-producing Escherichia coli (STEC) infections that cause severe gastroenteritis and life-threatening complications of hemolytic uremic syndrome (HUS).
Roland J. Pieters, Jie Shi, Haofei Hong (3766324), Zhicheng Liu, Xinfang Qin (11934355), Zhifang Zhou (1402630), Zhongkai Lu (1979209), Roland J. Pieters (154119), Zhimeng Wu, Xinfang Qin, Xia Li, Zhifang Zhou, Zhimeng Wu (1481236), Zhongkai Lu, Jie Shi (130059), Zhicheng Liu (587903), Haofei Hong, Xia Li (14984)   +17 more
core   +1 more source

A Novel Small Molecular Antibody, HER2-Nanobody, Inhibits Tumor Proliferation in HER2-Positive Breast Cancer Cells In Vitro and In Vivo

Frontiers in Oncology, 2021
Breast cancer is the most common malignant cancer in women worldwide, especially in developing countries. Herceptin is a monoclonal antibody with an antitumor effect in HER2-positive breast cancer. However, the large molecular weight of Herceptin limited
Yan Yan, Yan Yan, Xiao Cheng, Lin Li, Rumeng Zhang, Yong Zhu, Zhengsheng Wu, Zhengsheng Wu, Keshuo Ding, Keshuo Ding   +9 more
doaj   +1 more source