Results 11 to 20 of about 16,460 (261)
TCR-mimic bispecific nanobody-based T cell engager targeting intracellular tumor antigens for cancer immunotherapy [PDF]
Signal Transduction and Targeted TherapyT cell engager (TCE) immunotherapies have revolutionized the landscape of cancer treatment; however, their efficacy remains limited by the inaccessibility of intracellular tumor antigens.
Ziqiang Ding +7 more
doaj +2 more sources
Nanobody-Targeted Photodynamic Therapy: Nanobody Production and Purification [PDF]
, 2022 Nanobodies have recently been introduced to the field of photodynamic therapy (PDT) as a very promising strategy to target photosensitizers selectively to cancer cells. Nanobodies are known for their characteristic small size (15 kDa), high specificity, and high binding affinities.
Mashayekhi, Vida +4 more
core +6 more sources
Journal of Pharmaceutical Analysis, 2022 Recombinant human interferon α2b (rhIFNα2b) is widely used as an antiviral therapy agent for the treatment of hepatitis B and hepatitis C. The current identification test for rhIFNα2b is complex.
Chunming Rao
exaly +3 more sources
Penetration of Nanobody-Dextran Polymer Conjugates through Tumor Spheroids [PDF]
Pharmaceutics, 2023 Here we report the generation of nanobody dextran polymer conjugates (dextraknobs) that are loaded with small molecules, i.e., fluorophores or photosensitizers, for potential applications in cancer diagnostics and therapy.
Peter Bitsch +6 more
doaj +3 more sources
Nanobody-derived nanobiotechnology tool kits for diverse biomedical and biotechnology applications
International Journal of Nanomedicine, 2016 Yongzhong Wang,1 Zhen Fan,2 Lei Shao,3 Xiaowei Kong,1 Xianjuan Hou,1 Dongrui Tian,1 Ying Sun,1 Yazhong Xiao,1 Li Yu4 1School of Life Sciences, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei, People’s Republic of
Wang Y +8 more
doaj +1 more source
Identification and in vivo characterization of a brain-penetrating nanobody [PDF]
Fluids and Barriers of the CNS, 2020 Background Preclinical models to determine blood to brain transport ability of therapeutics are often ambiguous. In this study a method is developed that relies on CNS target-engagement and is able to rank brain-penetrating capacities. This method led to
Y Wouters +3 more
doaj +2 more sources
Current Issues in Molecular BiologyZearalenone (ZEN), a toxic estrogenic mycotoxin in cereals, threatens human and animal health through reproductive, immune, and cytotoxic effects, necessitating sensitive detection methods.
Ying Zeng +9 more
doaj +2 more sources
A Novel Anti-CD47 Nanobody Tetramer for Cancer Therapy
AntibodiesCD47 acts as a defense mechanism for tumor cells by sending a “don’t eat me” signal via its bond with SIRPα. With CD47’s overexpression linked to poor cancer outcomes, its pathway has become a target in cancer immunotherapy.
Nataliya M. Ratnikova +5 more
doaj +2 more sources
Structure of Nanobody Nb23 [PDF]
Molecules, 2021 Background: Nanobodies, or VHHs, are derived from heavy chain-only antibodies (hcAbs) found in camelids. They overcome some of the inherent limitations of monoclonal antibodies (mAbs) and derivatives thereof, due to their smaller molecular size and higher stability, and thus present an alternative to mAbs for therapeutic use.
Percipalle M. +4 more
openaire +5 more sources
Development of camelid monoclonal nanobody against SLC39A6 zinc transporter protein [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): SLC39A6 (solute carrier family 39) or LIV-1, is a zinc-transporter protein associated with estrogen-positive breast cancer and its metastatic spread.
Hajarsadat Ghaderi +4 more
doaj +1 more source