Results 41 to 50 of about 837,611 (284)
Single-domain antibodies for brain targeting [PDF]
, 2014 Smaller recombinant antibody fragments as single-domain antibodies (sdAbs) are emerging as credible alternatives because of their target specificity, high affinity, and cost-effective recombinant production. sdAbs have been forged into multivalent and multispecif ic therapeutics, or targeting moieties, that are able to shuttle their linked therapeutic ...
Lalatsa, Katerina, Moreira Leite, Diana
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Scientific Reports, 2021 The high binding affinities and specificities of antibodies have led to their use as drugs and biosensors. Single-domain VHH antibodies exhibit high specificity and affinity but have higher stability and solubility than conventional antibodies as they ...
Emina Ikeuchi +4 more
doaj +1 more source
In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development [PDF]
, 2017 Acknowledgments: The authors would like to acknowledge the funding support for this work from Scottish Enterprise [VNAR_001(2012)] and the Biotechnology and Biological Sciences Research Council (BB/K010905/1).Peer reviewedPublisher ...
Andrew J. Porter +11 more
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Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily [PDF]
, 2008 Background: Drosophila has six receptor protein tyrosine phosphatases (RPTPs), five of which are expressed primarily in neurons. Mutations in all five affect axon guidance, either alone or in combination.
Bahri, Sami +3 more
core +4 more sources
Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. [PDF]
, 2020 Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed. Single-domain antibodies (VHH) have been examined as a countermeasure for BoNT because of their high ...
Jin, Rongsheng +8 more
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Distinct cellular expression pattern of annexins in Hydra vulgaris. [PDF]
, 1992 The annexins are a structurally related family of Ca2+ and phospholipid binding proteins whose function has not been clearly defined. Further investigations of annexin function may be enhanced by studying simpler organisms that express fewer annexin gene
Bode, HR, Haigler, HT, Schlaepfer, DD
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PLoS ONE, 2014 Single domain antibodies are the small recombinant variable domains derived from camelid heavy-chain-only antibodies. They are renowned for their stability, in large part due to their ability to refold following thermal or chemical denaturation.
Dan Zabetakis +4 more
doaj +1 more source
PLoS ONE, 2022 Flu disease, with high mortality and morbidity, is caused by the influenza virus. Influenza infections are most effectively prevented through vaccination, but it requires annual reformulation due to the antigenic shift or drift of hemagglutinin and ...
Phuong Thi Hoang +8 more
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The Immunoglobulins of Cold-Blooded Vertebrates [PDF]
, 2014 Peer reviewedPublisher ...
Chen +22 more
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Cross-Reactive and Lineage-Specific Single Domain Antibodies against Influenza B Hemagglutinin
Antibodies, 2019 Influenza B virus (IBV) circulates in the human population and causes considerable disease burden worldwide, each year. Current IBV vaccines can struggle to mount an effective cross-reactive immune response, as strains become mismatched, due to constant ...
Walter Ramage +8 more
doaj +1 more source