Results 41 to 50 of about 594,568 (282)

Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes [PDF]

, 2009
Anti-hepatitis C virus (HCV) cross-neutralizing human monoclonal antibodies, directed against conserved epitopes on surface E2 glycoprotein, are central tools for understanding virus-host interplay, and for planning strategies for prevention and ...
Patel, Ah, Ball Jonathan K., Nicasio Mancini, Nicola Clementi, Sautto, G, Clementi, N., Ball, J.K., Diotti, R.A., Burioni, R., Mario Perotti, Arvind H Patel, Nitti Giovanni, Diotti, Ra, Clementi Massimo, CLEMENTI, NICOLA, BURIONI, ROBERTO, Sautto, G., CLEMENTI, MASSIMO, Perotti, M., Jonathan K Ball, Massimo Clementi, Nitti, G, Giovanni Nitti, Patel, A.H., Clementi, M., Perotti Mario, Ball, Jk, Perotti, M, Patel Arvind H., Roberta A Diotti, Giuseppe Sautto, Mancini Nicasio, Diotti Roberta A., Mancini, N., Roberto Burioni, Sautto Giuseppe, MANCINI, NICASIO, Clementi Nicola, Burioni Roberto, Nitti, G.   +39 more
core   +1 more source

Single-Domain Antibodies: Biology, Engineering and Emerging Applications

, 2018
Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications.
Henry, Kevin A., MacKenzie, C. Roger, Kevin A. Henry, C. Roger MacKenzie   +3 more
core   +1 more source

Evaluation of disulfide bond position to enhance the thermal stability of a highly stable single domain antibody.

PLoS ONE, 2014
Single domain antibodies are the small recombinant variable domains derived from camelid heavy-chain-only antibodies. They are renowned for their stability, in large part due to their ability to refold following thermal or chemical denaturation.
Dan Zabetakis, Mark A Olson, George P Anderson, Patricia M Legler, Ellen R Goldman   +4 more
doaj   +1 more source

Selection of intracellular single-domain antibodies targeting the HIV-1 Vpr protein by cytoplasmic yeast two-hybrid system.

PLoS ONE, 2014
The targeting of HIV-1 using antibodies is of high interest as molecular tools to better understand the biology of the virus or as a first step toward the design of new inhibitors targeting critical viral intracellular proteins.
Julie Matz, Cécile Hérate, Jérôme Bouchet, Nelson Dusetti, Odile Gayet, Daniel Baty, Serge Benichou, Patrick Chames   +7 more
doaj   +1 more source

Platelet integrin α 2 I-domain specific antibodies produced via domain specific DNA vaccination combined with variable gene phage display

, 2005
Antibodies are a powerful tool for structure/function studies of platelet proteins. However, classic immunisation frequently elicits antibody responses against domains of minor functional interest. Robust strategies to generate antibodies against defined
Deckmyn, H., Ouwehand, W.H., Hamaia, Samir W., Harmer, lan J., Stafford, P., Watkins, N.A., Deckmyn, Hans, Hughes, D.L., Hamaia, S.W., Harmer, I., Farndale, R.W., Farndale, Richard W., Hughes, Darren L., Stafford, Prachi, Schoolmeester, Anne, Watkins, Nicholas A., Schoolmeester, A., Ouwehand, Willem H.   +17 more
core   +1 more source

Enhancing neutralizing activity against influenza H1N1/PR8 by engineering a single-domain VL-M2 specific into a bivalent form.

PLoS ONE, 2022
Flu disease, with high mortality and morbidity, is caused by the influenza virus. Influenza infections are most effectively prevented through vaccination, but it requires annual reformulation due to the antigenic shift or drift of hemagglutinin and ...
Phuong Thi Hoang, Quynh Xuan Thi Luong, Seungchan Cho, Yongjun Lee, Kyungho Na, Ramadhani Qurrota Ayun, Thuy Thi Bich Vo, Taehyun Kim, Sukchan Lee   +8 more
doaj   +1 more source

Construction of Novel Bispecific Single-Domain Antibodies (BiSdAbs) with Potent Antiangiogenic Activities

Pharmaceutical Fronts, 2020
The development of bispecific antibodies (BsAbs) has had a profound impact on cancer immunotherapy. Single-domain antibodies (SdAbs) could offer advantages over other antibody formats for the generation of a BsAbs, such as small size (∼12–15 kDa), with ...
Xianglei Liu, Tianyuan Sun, Qiuhan Ge, Jianwei Zhu   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Selection of functional human antibodies from retroviral display libraries

, 2004
Antibody library technology represents a powerful tool for the discovery and design of antibodies with high affinity and specificity for their targets.
Álvarez-Vallina, Luis, Christian J. Buchholz, Carsten Finger, Klaus Cichutek, Compte, Marta, Johannes H. Urban, Finger, Carsten, Urban, Johannes H., Richard M. Schneider, Schneider, Richard M., Cichutek, Klaus, Buchholz, Christian, Marta Compte   +12 more
core   +1 more source

Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer

OncoImmunology, 2022
Retargeting of T lymphocytes toward cancer cells by bispecific antibodies has demonstrated its therapeutic potential, with one such antibody approved for the treatment of acute lymphoblastic leukemia (blinatumomab) and several other in clinical trials ...
Antonio Tapia-Galisteo, Íñigo Sánchez Rodríguez, Oscar Aguilar-Sopeña, Seandean Lykke Harwood, Javier Narbona, Mariola Ferreras Gutierrez, Rocío Navarro, Laura Martín-García, Cesáreo Corbacho, Marta Compte, Javier Lacadena, Francisco J. Blanco, Patrick Chames, Pedro Roda-Navarro, Luis Álvarez-Vallina, Laura Sanz   +15 more
doaj   +1 more source