Results 31 to 40 of about 594,568 (282)
, 2023 Data includes supplementary information for the research article "Physicochemical differences between camelid single-domain antibodies and mammalian antibodies".
Eskier, D (via Mendeley Data)
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Application of single-domain antibodies ("nanobodies") to laboratory diagnosis
, 2021 Antibodies have proven to be central in the development of diagnostic methods over decades, moving from polyclonal antibodies to the milestone development of monoclonal antibodies.
Pillay, Tahir S., Muyldermans, Serge
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Enhancement of toxin- and virus-neutralizing capacity of single-domain antibody fragments by N-glycosylation [PDF]
, 2009 Single-domain antibody fragments (VHHs) have several beneficial properties as compared to conventional antibody fragments. However, their small size complicates their toxin- and virus-neutralizing capacity.
Fijten, H.P.D. +5 more
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, 2022 While covalent drug discovery is reemerging as an important route to small molecule therapeutic leads, strategies for the discovery and engineering of protein-based irreversible binding agents remain limited. Here, we describe the use of yeast display, a
Rafael, Alcala-Torano +7 more
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Ricin Detection Using Phage Displayed Single Domain Antibodies
Sensors, 2009 Phage-displayed single domain antibodies (sdAb) were compared to monomeric solubly expressed sdAb and llama polyclonal antibodies for the detection of ricin. SdAb are comprised of the variable domain derived from camelid heavy chain only antibodies (HcAb)
Ellen R. Goldman +5 more
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Nature Communications, 2020 Here, using a humanized phage display library with recombinant SARS- CoV-2 receptor binding domain (RBD) proteins, the authors identify a number of single domain antibodies (sdAbs) that neutralize SARS-CoV-2 in vitro by inhibiting the interaction of the ...
Xiaojing Chi +9 more
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Application Progress of the Single Domain Antibody in Medicine
International Journal of Molecular Sciences, 2023 The camelid-derived single chain antibody (sdAb), also termed VHH or nanobody, is a unique, functional heavy (H)-chain antibody (HCAb). In contrast to conventional antibodies, sdAb is a unique antibody fragment consisting of a heavy-chain variable domain. It lacks light chains and a first constant domain (CH1).
Huaping Tang, Yuan Gao, Jiangyuan Han
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sdAb-DB: The Single Domain Antibody Database [PDF]
ACS Synthetic Biology, 2018 The Single Domain Antibody Database, or sdAb-DB, ( www.sdab-db.ca ) is the first freely available repository for single domain antibodies and related classes of proteins. Due to their small size, modular structure, and ease of expression, single domain antibodies (sdAb) have a wide range of applications, including as a rational design tool, and are ...
Emily E. Wilton +4 more
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Progress of Single-domain Antibodies in Molecular Imaging of Tumors
Zhongliu Fangzhi Yanjiu, 2019 A single-domain antibody (sdAb) is the variable region extracted from antibodies with only heavy chains found in camelid serum. Single-domain antibodies have the characteristics of easy expression, good solubility, great stability and weak immunogenicity.
ZHANG Meixin +5 more
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Scientific Reports, 2021 The high binding affinities and specificities of antibodies have led to their use as drugs and biosensors. Single-domain VHH antibodies exhibit high specificity and affinity but have higher stability and solubility than conventional antibodies as they ...
Emina Ikeuchi +4 more
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