Results 51 to 60 of about 594,568 (282)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies

, 2013
PMCID: PMC3581439This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Ovecka, M, Coulstock, E, Sepp Armin, Foster, J, Sepp, A, Edward Coulstock (381775), Jerome Burnet (381784), Burnet Jerome, Goodall Laura, Mudd, C, Edward Coulstock, Jane Sosabowski (381776), Mudd Clare, Davies, M, Clare Mudd (381780), Marie Davies, Sosabowski, J, Armin Sepp, Sosabowski Jane, Ovečka Milan, Dunlevy, G, Laura Goodall, Jerome Burnet, Coulstock Edward, Milan Ovečka, Dunlevy Gráinne, Gráinne Dunlevy, Julie Foster, Prince Rob, Foster Julie, Rob Prince, Clare Mudd, Rob Prince (381778), Laura Goodall (381779), Julie Foster (381783), Walker Adam, Goodall, L, Adam Walker, Gráinne Dunlevy (381785), Marie Davies (381782), Adam Walker (381786), Davies Marie, Armin Sepp (381781), Burnet, J, Prince, R, Walker, A, Jane Sosabowski, Milan Ovečka (381777)   +47 more
core   +1 more source

Targeting the Brain with Single-Domain Antibodies: Greater Potential Than Stated So Far?

, 2023
Treatments for central nervous system diseases with therapeutic antibodies have been increasingly investigated over the last decades, leading to some approved monoclonal antibodies for brain disease therapies.
Pierre-André Lafon, Rondard, Philippe, Mireille Elodie Tsitokana, Philippe Rondard, Prézeau, Laurent, Pin, Jean-Philippe, Laurent Prézeau, Jean-Philippe Pin, Tsitokana, Mireille Elodie, Lafon, Pierre-André   +9 more
core   +1 more source

Camelid Single-Domain Antibodies: Historical Perspective and Future Outlook

Frontiers in Immunology, 2017
Tremendous effort has been expended over the past two and a half decades to understand many aspects of camelid heavy chain antibodies, from their biology, evolution, and immunogenetics to their potential applications in various fields of research and ...
Mehdi Arbabi-Ghahroudi, Mehdi Arbabi-Ghahroudi   +1 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Novel FGFR4-Targeting Single-Domain Antibodies for Multiple Targeted Therapies against Rhabdomyosarcoma [PDF]

, 2020
The fibroblast growth factor receptor 4 (FGFR4) is overexpressed in rhabdomyosarcoma (RMS) and represents a promising target for treatments based on specific and efficient antibodies.
Dzhumashev, Dzhangar, Weber, Florian, Nagjie Alijaj, Sandrine Moutel, Gray, Maxim, Dzhangar Dzhumashev, Meier, Gianmarco, Gianmarco Meier, Bernasconi, Michele, Maxim Gray, Paola Luciani, Luciani, Paola, Beat W. Schäfer, Michele Bernasconi, Zelia L. Gouveia, Florian Weber, Moutel, Sandrine, Roveri, Maurizio, Schäfer, Beat W, Rössler, Jochen K., Maurizio Roveri, Jochen K. Rössler, Franck Perez, Alijaj, Nagjie, Gouveia, Zelia L, Perez, Franck   +25 more
core   +1 more source

Single domain antibodies in the development of immunosensors for diagnostics

International Journal of Biological Macromolecules, 2020
Scientific advances in nanotechnology and nanoscience have enabled stability optimization and signal amplification in immunoassays by taking advantage of unique properties of nanomaterials. Biosensors based on antibodies and their fragments, also called immunosensors, are compact tools capable of providing refined antigen detection capacity.
Erika A, Bastos-Soares, Rosa Maria O, Sousa, Ana Fidelina, Gómez, Jorge, Alfonso, Anderson M, Kayano, Fernando B, Zanchi, Maribel E, Funes-Huacca, Rodrigo G, Stábeli, Andreimar M, Soares, Soraya S, Pereira, Carla Freire C, Fernandes   +10 more
openaire   +2 more sources

Single-Domain Antibodies As Therapeutics against Human Viral Diseases

Frontiers in Immunology, 2017
In full-size formats, monoclonal antibodies have been highly successful as therapeutics against cancer and immune diseases. However, their large size leads to inaccessibility of some epitopes and relatively high production costs.
Yanling Wu, Shibo Jiang, Tianlei Ying
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source