Results 1 to 10 of about 611,316 (117)

Single-domain antibody-based protein degrader for synucleinopathies. [PDF]

Mol Neurodegener
Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor and neuropsychiatric symptoms.
Jiang Y, Lin Y, Tetlow AM, Pan R, Ji C, Kong XP, Congdon EE, Sigurdsson EM.   +7 more
europepmc   +2 more sources

Development of a Chicken Immunoglobulin Heavy Chain Variable Region (VH) Single-Domain Antibody (sdAb) Against Calsequestrin (CSQ) and Its Application. [PDF]

Antibodies (Basel)
Background/Objectives: Calsequestrin (CSQ) is a calcium-binding protein that is highly soluble and can serve as a solubility-enhancing fusion tag in recombinant protein expression.
Lee S, Park S, Yang H, Cho G, Lee SY, Lee D, Tae N, Kim DH, Chung J.   +8 more
europepmc   +2 more sources

Single-domain antibody screening by is PLA-seq

Life Science Alliance, 2022
This study describes a high-sensitive, high-throughput single-domain antibody library screening approach, which is applicable for any given interested protein at single-cell resolution by is PLA-seq.
Yueyuan Yin, Fei Yan, Ruimin Zhou, Mingchen Li, Jinyi Ma, Zhe Liu, Zhenyi Ma   +6 more
doaj   +1 more source

Preparation and identification of a single domain antibody specific for adenovirus vectors and its application to the immunoaffinity purification of adenoviruses

AMB Express, 2022
Adenovirus belongs to the family of Adenoviridae. As a vaccine carrier, it has high safety and stimulates the body to produce cellular immunity and humoral immunity.
Yi Cheng, Yanxia Hao, Fuxiang Bao, Huimin Zhang, Yanlong Liu, Kexin Ao, Shan Fu, Qiyao Wu, Zhi Wang   +8 more
doaj   +1 more source

Novel single-domain antibodies against the EGFR domain III epitope exhibit the anti-tumor effect

Journal of Translational Medicine, 2020
Background Monoclonal antibodies (mAbs) have been used for cancer therapy. They are large and have some disadvantages limiting their use. Smaller antibody fragments are needed as their alternatives. A fully human single-domain antibody (sdAb) has a small
Tao Chen, Xue Liu, Haifeng Hong, Henry Wei   +3 more
doaj   +1 more source

Therapeutic Phage Display-Derived Single-Domain Antibodies for Pandemic Preparedness

Antibodies, 2023
Driven by necessity, the COVID-19 pandemic caused by SARS-CoV-2 has accelerated the development and implementation of new vaccine platforms and other viral therapeutics. Among these is the therapeutic use of antibodies including single-domain antibodies,
Janet M. Daly, Theam Soon Lim, Kevin C. Gough   +2 more
doaj   +1 more source

Stabilization of a Broadly Neutralizing Anti-Chikungunya Virus Single Domain Antibody

Frontiers in Medicine, 2021
A single domain antibody (clone CC3) previously found to neutralize a vaccine strain of the chikungunya virus (PRNT50 = 2. 5 ng/mL) was found to be broadly neutralizing.
Jinny L. Liu, Emily M. Webb, Dan Zabetakis, Crystal W. Burke, Christina L. Gardner, Pamela J. Glass, Patricia M. Legler, James Weger-Lucarelli, George P. Anderson, Ellen R. Goldman   +9 more
doaj   +1 more source

Single Domain Antibody application in bacterial infection diagnosis and neutralization

Frontiers in Immunology, 2022
Increasing antibiotic resistance to bacterial infections causes a serious threat to human health. Efficient detection and treatment strategies are the keys to preventing and reducing bacterial infections. Due to the high affinity and antigen specificity,
Qian Qin, Qian Qin, Hao Liu, Wenbo He, Yucheng Guo, Jiaxin Zhang, Junjun She, Fang Zheng, Sicai Zhang, Serge Muyldermans, Yurong Wen, Yurong Wen   +11 more
doaj   +1 more source

Structure of a VHH isolated from a naïve phage display library

BMC Research Notes, 2019
Objective To determine the X-ray structure and biophysical properties of a Camelid VHH isolated from a naïve phage display library. Results Single domain antibodies (VHH) derived from the unique immune system of the Camelidae family have gained traction ...
Brandy White, Ian Huh, Cory L. Brooks
doaj   +1 more source

mRNA Encoding a Bispecific Single Domain Antibody Construct Protects against Influenza A Virus Infection in Mice

Molecular Therapy: Nucleic Acids, 2020
To date, mRNA-based biologics have mainly been developed for prophylactic and therapeutic vaccination to combat infectious diseases or cancer. In the past years, optimization of the characteristics of in vitro transcribed mRNA has led to significant ...
Lien Van Hoecke, Rein Verbeke, Dorien De Vlieger, Heleen Dewitte, Kenny Roose, Sharon Van Nevel, Olga Krysko, Claus Bachert, Bert Schepens, Ine Lentacker, Xavier Saelens   +10 more
doaj   +1 more source