Results 31 to 40 of about 869,643 (295)

In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development [PDF]

, 2017
Acknowledgments: The authors would like to acknowledge the funding support for this work from Scottish Enterprise [VNAR_001(2012)] and the Biotechnology and Biological Sciences Research Council (BB/K010905/1).Peer reviewedPublisher ...
Andrew J. Porter, Andrew J. Porter, Caroline Jane Barelle, Dawn Cornock, Gerard Donohoe, John Steven, Kenneth Saunders, Marina Kovaleva, Miguel F. Carvalho, Mischa R. Müller, Obinna C. Ubah, Thomas Baddeley   +11 more
core   +2 more sources

Single domain antibody multimers confer protection against rabies infection.

PLoS ONE, 2013
Post-exposure prophylactic (PEP) neutralizing antibodies against Rabies are the most effective way to prevent infection-related fatality. The outer envelope glycoprotein of the Rabies virus (RABV) is the most significant surface antigen for generating ...
Bhargavi M Boruah, Dawei Liu, Duan Ye, Tie-Jun Gu, Chun-Lai Jiang, Mingsheng Qu, Edward Wright, Wei Wang, Wen He, Changzhen Liu, Bin Gao   +10 more
doaj   +1 more source

Single‐Domain Antibodies and Their Utility

Current Protocols in Immunology, 2013
AbstractEngineered monoclonal antibody fragments have gained market attention due to their versatility and tailor‐made potential and are now considered to be an important part of future immunobiotherapeutics. Single‐domain antibodies (sdAbs), also known as nanobodies, are derived from VHHs [variable domains (V) of heavy‐chain‐only antibodies (HCAb)] of
Baral, Toya Nath, MacKenzie, Roger, Ghahroudi, Mehdi Arbabi   +2 more
openaire   +4 more sources

Engineering a novel IgG-like bispecific antibody against enterovirus A71

Biochemistry and Biophysics Reports, 2020
Frequent outbreaks of enterovirus A71 (EVA71) occur in the Asia-Pacific area, and these are closely associated with severe neurological symptoms in young children. No effective antiviral therapy is currently available for the treatment of EVA71 infection.
Hsiang-Ching Wang, Hui-Chen Hung, Peng-Nien Huang, Yu-An Kung, Sung-Nien Tseng, Yun-Ming Wang, Shin-Ru Shih, John Tsu-An Hsu   +7 more
doaj   +1 more source

Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire. [PDF]

, 2016
Staphylococcus aureus is both an important pathogen and a human commensal. To explore this ambivalent relationship between host and microbe, we analysed the memory humoral response against IsdB, a protein involved in iron acquisition, in four healthy ...
Abdiche, Yasmina, Chaparro-Riggers, Javier, Deng, Xiaodi, Foletti, Davide, Glanville, Jacob, Hasa-Moreno, Adela, Lindquist, Kevin, Melton Witt, Jody, Ni, Irene, Pham, Amber, Pitts, Steven, Pons, Jaume, Rajpal, Arvind, Shelton, David, Sirota, Marina, Strop, Pavel, Sundar, Purnima D, Yeung, Yik Andy   +17 more
core   +2 more sources

Single Domain Antibodies as New Biomarker Detectors [PDF]

Diagnostics, 2017
Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for monitoring the progression of diseases.
Chiuan Herng Leow, Katja Fischer, Chiuan Herng Leow, Qin Cheng, Candy Chuah, James S. McCarthy   +5 more
openaire   +4 more sources

Use of single-chain antibody derivatives for targeted drug delivery [PDF]

, 2016
Single-chain antibodies (scFvs), which contain only the variable domains of full-length antibodies, are relatively small molecules that can be used for selective drug delivery.
Ahmadzadeh, V., Erfani-Moghadam, V., Jaliani, H.Z., Khalili, M., Safdari, Y., Zarei, V.   +5 more
core   +1 more source

Llama-Derived Single Domain Antibodies Specific for Abrus Agglutinin

Toxins, 2011
Llama derived single domain antibodies (sdAb), the recombinantly expressed variable heavy domains from the unique heavy-chain only antibodies of camelids, were isolated from a library derived from llamas immunized with a commercial abrin toxoid ...
James P. Carney, Rachael Bernstein, Eric A. E. Garber, Jennifer L. Walker, Thomas W. O’Brien, Alena Calm, Jinny L. Liu, Ellen R. Goldman, Scott Walper, Dan Zabetakis, George P. Anderson   +10 more
doaj   +1 more source

Horizontal gene transfer contributed to the evolution of extracellular surface structures [PDF]

, 2012
The single-cell layered ectoderm of the fresh water polyp Hydra fulfills the function of an epidermis by protecting the animals from the surrounding medium.
Altstätter, Johannes, Böttger, Angelika, David, Charles N., Deutzmann, Rainer, Doxey, Andrew C., Gabius, Hans-Joachim, Geissner, Andreas, Heim, Astrid, Hess, Michael W., McConkey, Brendan J., Münder, Sandra, Pauly, Barbara, Pfaller, Kristian, Salvenmoser, Willi   +13 more
core   +1 more source

Single-domain antibodies as therapeutics for solid tumor treatment

Acta Pharmaceutica Sinica B
Single-domain antibodies (sdAbs), initially identified in camelids or sharks and commonly referred to as nanobodies or VNARs, have emerged as a promising alternative to conventional therapeutic antibodies.
Mingkai Wang, Tianlei Ying, Yanling Wu
doaj   +1 more source