Results 21 to 30 of about 58,013 (257)
Frontiers in Immunology, 2023 Background Chimeric antigen receptor (CAR)-T cell therapy has established itself as a potent therapeutic option for certain patients with relapsed/refractory (R/R) hematologic malignancies.
F. Nasiri +2 more
semanticscholar +1 more source
Single VHH-directed BCMA CAR-NK cells for multiple myeloma
Experimental Hematology & Oncology, 2023 Natural killer (NK) cells are promising alternatives for the production of “off-the-shelf” CAR products, posing a lower risk of cytokine release syndrome (CRS) than CAR-T cells.
Quan Ren +7 more
semanticscholar +1 more source
Structural Classification of CDR-H3 in Single-Domain VHH Antibodies.
Methods in molecular biology, 2023 The immune systems protect vertebrates from foreign molecules or antigens, and antibodies are important mediators of this system. The sequences and structural features of antibodies vary depending on species.
Daisuke Kuroda, K. Tsumoto
semanticscholar +1 more source
Frontiers in Molecular Biosciences, 2023 Introduction: In this study, we demonstrate the feasibility of yeast surface display (YSD) and nextgeneration sequencing (NGS) in combination with artificial intelligence and machine learning methods (AI/ML) for the identification of de novo humanized ...
Paul Arras +13 more
semanticscholar +1 more source
Isolation of Novel EGFR-Specific VHH Domains [PDF]
SLAS Discovery, 2009 Epidermal growth factor receptor (EGFR) is overexpressed or mutated in a high percentage of tumors. EGFR has long been considered a promising target for cancer diagnostic and therapeutic applications. However, monoclonal antibodies and other large antibody constructs diffuse into tumors slowly, limiting their efficacy. To develop lower molecular weight
Elizabeth B, Gottlin +5 more
openaire +2 more sources
Lactobacillli expressing llama VHH fragments neutralise Lactococcusphages [PDF]
BMC Biotechnology, 2007 Abstract Background Bacteriophages infecting lactic acid bacteria (LAB) are widely acknowledged as the main cause of milk fermentation failures. In this study, we describe the surface-expression as well as the secretion of two functional llama heavy-chain antibody fragments, one binding to the major capsid protein ...
Moineau Sylvain +6 more
openaire +3 more sources
Peptide Linker Affecting the Activity Retention Rate of VHH in Immunosorbents
Biomolecules, 2020 VHH-based immunosorbents are an emerging and promising tool for the removal of toxic substances from plasma. However, the small size of VHHs is a double-edged sword, bringing both benefits and drawbacks to the immunosorbent.
Da Li +5 more
doaj +1 more source
Llama nanoantibodies with therapeutic potential against human norovirus diarrhea. [PDF]
PLoS ONE, 2015 Noroviruses are a major cause of acute gastroenteritis, but no vaccines or therapeutic drugs are available. Llama-derived single chain antibody fragments (also called VHH) are small, recombinant monoclonal antibodies of 15 kDa with several advantages ...
Lorena Garaicoechea +8 more
doaj +1 more source
mAbs, 2023 In this study, we generated a novel library approach for high throughput de novo identification of humanized single-domain antibodies following camelid immunization. To achieve this, VHH-derived complementarity-determining regions-3 (CDR3s) obtained from
Paul Arras +9 more
semanticscholar +1 more source
VHH-Based Bispecific Antibodies Targeting Cytokine Production [PDF]
Frontiers in Immunology, 2017 Proinflammatory cytokines, such as TNF, IL-6, and IL-1, play pathogenic roles in multiple diseases and are attractive targets for biologic drugs. Because proinflammatory cytokines possess non-redundant protective and immunoregulatory functions, their systemic neutralization carries the potential for unwanted side effects.
Maxim A. Nosenko +18 more
openaire +3 more sources