Results 21 to 30 of about 38,752 (185)
mAbs, 2022 Controlled Fab arm exchange (cFAE) has proven to be a generic and versatile technology for the efficient generation of IgG-like bispecific antibodies (DuoBodies or DBs), with several in clinical development and one product, amivantamab, approved by the ...
Desislava Yanakieva +9 more
doaj +1 more source
Discrete analysis of camelid variable domains: sequences, structures, and in-silico structure prediction [PDF]
PeerJ, 2020 Antigen binding by antibodies requires precise orientation of the complementarity- determining region (CDR) loops in the variable domain to establish the correct contact surface.
Akhila Melarkode Vattekatte +9 more
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VHHs as tools for therapeutic protein delivery to the central nervous system
Fluids and Barriers of the CNS, 2022 Background The blood brain barrier (BBB) limits the therapeutic perspective for central nervous system (CNS) disorders. Previously we found an anti-mouse transferrin receptor (TfR) VHH (Nb62) that was able to deliver a biologically active neuropeptide ...
Yessica Wouters +5 more
doaj +1 more source
Frontiers in Immunology, 2017 The activity of tumor necrosis factor (TNF), a cytokine involved in inflammatory pathologies, can be inhibited by antibodies or trap molecules. Herein, llama-derived variable heavy-chain domains of heavy-chain antibody (VHH, also called Nanobodies™) were
Els Beirnaert +14 more
doaj +1 more source
Development of VHH antibodies against dengue virus type 2 NS1 and comparison with monoclonal antibodies for use in immunological diagnosis. [PDF]
PLoS ONE, 2014 The possibility of using variable domain heavy-chain antibodies (VHH antibodies) as diagnostic tools for dengue virus (DENV) type 2 NS1 protein was investigated and compared with the use of conventional monoclonal antibodies.
Aneela Fatima +7 more
doaj +1 more source
Lactobacilli as a Vector for Delivery of Nanobodies against Norovirus Infection
Pharmaceutics, 2022 Passive administration of neutralizing antibodies (Abs) is an attractive strategy for the control of gastrointestinal infections. However, an unanswered practical concern is the need to assure the stability of sufficient amounts of orally administered ...
Yoshikazu Yuki +8 more
doaj +1 more source
Scientific Reports, 2018 Nucleolin arises as a relevant target for cancer therapy, as it is overexpressed at the surface of cancer and angiogenic endothelial cells thus enabling a dual cellular targeting strategy.
Sofia Romano +4 more
doaj +1 more source
Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies
mAbs, 2021 The respiratory virus responsible for coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected nearly every aspect of life worldwide, claiming the lives of over 3.9 million people globally, at the ...
Maxwell A. Stefan +15 more
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Intracellular VHHs to monitor and modulate GPCR signaling
Frontiers in Endocrinology, 2022 Single-domain antibody fragments, also known as VHHs or nanobodies, have opened promising avenues in therapeutics and in exploration of intracellular processes. Because of their unique structural properties, they can reach cryptic regions in their cognate antigen.
Pauline Raynaud +9 more
openaire +5 more sources
BIO IntegrationBackground: Bladder cancer (BLCA) is one of the most common malignancies and the second most frequent urogenital tract tumor. Cell and gene therapy, which offer many advantages in treating BLCA, are urgently needed.
Jinping Niu +7 more
doaj +1 more source