Results 1 to 10 of about 112,778 (72)

A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors

Frontiers in Immunology, 2023
BackgroundImmune checkpoint therapies have led to significant breakthroughs in cancer patient treatment in recent years. However, their efficiency is variable, and resistance to immunotherapies is common.
Shawn Iadonato, Yulia Ovechkina, Kurt Lustig, Jessica Cross, Nathan Eyde, Emily Frazier, Neda Kabi, Chen Katz, Remington Lance, David Peckham, Shaarwari Sridhar, Carla Talbaux, Isabelle Tihista, Mei Xu, Thierry Guillaudeux   +14 more
doaj   +1 more source

Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells

Innate Immunity, 2021
Crohn's disease activates the inflammatory reactions to induce intestinal disorders. Enteral nutrition (EN) could exert general immunomodulatory effects.
Di Zhao, Bo Yang, Chen Ye, Shaoyi Zhang, Xiaoqiong Lv, Qiyi Chen   +5 more
doaj   +1 more source

PD-1/PD-L1 immune checkpoint therapy demonstrates favorable safety profile in patients with autoimmune and cholestatic liver disease

Frontiers in Immunology
IntroductionImmune checkpoint inhibitors (ICI) have revolutionized the treatment of many malignancies in recent years. However, immune−related adverse events (irAE) are a frequent concern in clinical practice.
Lorenz Kocheise, Lorenz Kocheise, Ignazio Piseddu, Ignazio Piseddu, Joscha Vonderlin, Joscha Vonderlin, Eric T. Tjwa, Eric T. Tjwa, Gustav Buescher, Gustav Buescher, Lucy Meunier, Lucy Meunier, Pia Goeggelmann, Francesca Fianchi, Francesca Fianchi, Jérôme Dumortier, Jérôme Dumortier, Mar Riveiro Barciela, Mar Riveiro Barciela, Tom J. G. Gevers, Tom J. G. Gevers, Tom J. G. Gevers, Benedetta Terziroli Beretta-Piccoli, Benedetta Terziroli Beretta-Piccoli, Benedetta Terziroli Beretta-Piccoli, Benedetta Terziroli Beretta-Piccoli, Maria-Carlota Londoño, Maria-Carlota Londoño, Sona Frankova, Sona Frankova, Thomas Roesner, Vincent Joerg, Vincent Joerg, Constantin Schmidt, Constantin Schmidt, Fabian Glaser, Fabian Glaser, Jan P. Sutter, Jan P. Sutter, Thorben W. Fründt, Thorben W. Fründt, Ansgar W. Lohse, Ansgar W. Lohse, Samuel Huber, Samuel Huber, Johann von Felden, Johann von Felden, Marcial Sebode, Marcial Sebode, Kornelius Schulze, Kornelius Schulze   +50 more
doaj   +1 more source

Association between peripheral eosinophilia, JESREC score, and olfactory dysfunction in patients with chronic rhinosinusitis

Frontiers in Immunology
ObjectiveThe purpose was to evaluate the relationship between peripheral eosinophilia, Japan Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) score, and olfactory dysfunction in chronic rhinosinusitis (CRS) patients and ...
Ling Zhang, Haifeng Li, Tao Wang, Zhu Wang, Yang Wu, Siquan Guo, Wenjing Li, Yeru Zhou, Haixiang Xue, Jianqiang You   +9 more
doaj   +1 more source

Immunogenic Cell Death in Cancer: From Benchside Research to Bedside

, 2016
Classically, anti-cancer therapies have always been applied with the primary aim of tumor debulking achieved through widespread induction of cancer cell death.
Abhishek D. Garg, Patrizia Agostinis
core   +1 more source

Progress in molecular diagnosis and treatment of chronic mucocutaneous candidiasis

Frontiers in Immunology
Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent infections with Candida of the skin, nails, and mucous membrane. It is a rare and severe disease resulting from autoimmune defects or immune dysregulations.
Danrui Jing, Guanzhao Liang, Guanzhao Liang, Guanzhao Liang, Xiaofang Li, Xiaofang Li, Xiaofang Li, Weida Liu, Weida Liu, Weida Liu, Weida Liu   +10 more
doaj   +1 more source

Therapeutic targets and potential delivery systems of melatonin in osteoarthritis

Frontiers in Immunology
Osteoarthritis (OA) is a highly prevalent age-related musculoskeletal disorder that typically results in chronic pain and disability. OA is a multifactorial disease, with increased oxidative stress, dysregulated inflammatory response, and impaired matrix
Zhilin Xiong, Guoxuan Peng, Jin Deng, Miao Liu, Xu Ning, Yong Zhuang, Hua Yang, Hong Sun, Hong Sun   +8 more
doaj   +1 more source

Clinical utility of and correlation between Sniffin' Sticks and TIB smell identification test (TIBSIT) among Hong Kong Chinese with or without chronic rhinosinusitis

Frontiers in Allergy
IntroductionOlfactory dysfunction (OD) is common among patients with chronic rhinosinusitis (CRS). Validated and culturally specific tests, such as the “Sniffin’ Sticks” test (SST) and the TIB Smell Identification Test (TIBSIT), are crucial for the ...
Hugo W. F. Mak, Shi Yeung Ho, Jane C. Y. Wong, Valerie Chiang, Elaine Lee, Jackie S. H. Yim, Birgitta Y. H. Wong, Philip H. Li   +7 more
doaj   +1 more source

How to translate genetic findings into clinical applications in spondyloarthritis?

Frontiers in Immunology
Spondyloarthritis (SpA) is characterized by a strong genetic predisposition evidenced by the identification of up to 50 susceptibility loci, in addition to HLA-B27, the major genetic factor associated with the disease.
Eva Frison, Eva Frison, Maxime Breban, Maxime Breban, Maxime Breban, Félicie Costantino, Félicie Costantino, Félicie Costantino   +7 more
doaj   +1 more source

Comparison of the single-cell and single-nucleus hepatic myeloid landscape within decompensated cirrhosis patients

Frontiers in Immunology
Background and aimsA complete understanding of disease pathophysiology in advanced liver disease is hampered by the challenges posed by clinical specimen collection.
Lukas Van Melkebeke, Lukas Van Melkebeke, Jef Verbeek, Jef Verbeek, Dora Bihary, Dora Bihary, Markus Boesch, Bram Boeckx, Bram Boeckx, Rita Feio-Azevedo, Lena Smets, Marie Wallays, Eveline Claus, Lawrence Bonne, Geert Maleux, Olivier Govaere, Hannelie Korf, Diether Lambrechts, Diether Lambrechts, Schalk van der Merwe, Schalk van der Merwe   +20 more
doaj   +1 more source