Results 31 to 40 of about 109,879 (70)

Hepatic and pulmonary macrophage activity in a mucosal challenge model of Ebola virus disease

Frontiers in Immunology
BackgroundThe inflammatory macrophage response contributes to severe Ebola virus disease, with liver and lung injury in humans.ObjectiveWe sought to further define the activation status of hepatic and pulmonary macrophage populations in Ebola virus ...
Timothy G. Wanninger, Timothy G. Wanninger, Omar A. Saldarriaga, Esteban Arroyave, Daniel E. Millian, Jason E. Comer, Slobodan Paessler, Heather L. Stevenson   +7 more
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A comprehensive nomogram for assessing the prognosis of non-small cell lung cancer patients receiving immunotherapy: a prospective cohort study in China

Frontiers in Immunology
ObjectiveIn China, lung cancer ranks first in both incidence and mortality among all malignant tumors. Non-small cell lung cancer (NSCLC) constitutes the vast majority of cases, accounting for 80% to 85% of cases.
Hongmei Li, Yuliang Yuan, Qianjie Xu, Guangzhong Liang, Zuhai Hu, Xiaosheng Li, Wei Zhang, Haike Lei   +7 more
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Analysis of immunogenicity and purification methods in conjugated polysaccharide vaccines: a new approach in fighting pathogenic bacteria

Frontiers in Immunology
Carbohydrates are commonly found in conjunction with lipids or proteins, resulting in the formation of glycoconjugates such as glycoproteins, glycolipids, and proteoglycans.
Arya Sheikhi, Arya Sheikhi, Mina Shirmohammadpour, Mina Shirmohammadpour, Nima Mahdei Nasirmahalleh, Bahman Mirzaei   +5 more
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The influence of immune checkpoint blockade on the outcomes of allogeneic hematopoietic stem cell transplantation

Frontiers in Immunology
The principle of immune checkpoint blockade therapy is based on the activation of T cells. Immune checkpoint inhibitors (ICIs), such as anti-PD-1/PD-L1 and anti-CTLA-4 antibodies, have demonstrated effectiveness in treating solid tumors by reinvigorating
Yalei Hu, Yalei Hu, Yuxin Wang, Yuxin Wang, Kaili Min, Kaili Min, Huisheng Zhou, Huisheng Zhou, Xiaoning Gao, Xiaoning Gao   +9 more
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Case report: Modified transplantation for pediatric patients with pyruvate kinase deficiency

Frontiers in Immunology
Pyruvate kinase deficiency (PKD) is an autosomal recessive genetic disease caused by mutations in the PKLR gene. To date, the clinical manifestations of PKD are heterogeneous, ranging from fetal anemia, neonatal jaundice, and severe chronic hemolytic ...
Yuhui Pang, Xiaoyu Qi, Jiayue Qin, Xiaoran Zhai, Rongxiao Wang, Jianzhu Cao, Na Zhang, Jinxia Liu, Jianying Li, Weihai Wu, Shanshan Wei, Jingjing Zhang, Shaofei Zhang, Yaochen Zhang, Yan Yue   +14 more
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COVID-19 mitigates the response to TKIs in patients with CML via the inhibition of T-cell immunity

Frontiers in Immunology
IntroductionChronic myeloid leukemia (CML) is a severe hematological malignancy characterized by BCR-ABL fusion gene. The advent of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL has improved the landscape of CML treatment dramatically.
Na He, Guosheng Li, Jinting Liu, Wancheng Liu, Ruifeng Tian, Daoxin Ma   +5 more
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Comprehensive single-cell and bulk transcriptomic analyses to develop an NK cell-derived gene signature for prognostic assessment and precision medicine in breast cancer

Frontiers in Immunology
BackgroundNatural killer (NK) cells play crucial roles in mediating anti-cancer activity in breast cancer (BRCA). However, the potential of NK cell-related molecules in predicting BRCA outcomes and guiding personalized therapy remains largely unexplored.
Qianshan Hou, Chunzhen Li, Yuhui Chong, Haofeng Yin, Yuchen Guo, Lanjie Yang, Tianliang Li, Shulei Yin   +7 more
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PTX3 is expressed in terminal lymphatics and shapes their organization and function

Frontiers in Immunology
IntroductionThe lymphatic system is a multifaceted regulator of tissue homeostasis and an integral part of immune responses. Previous studies had shown that subsets of lymphatic endothelial cells (LEC) express PTX3, an essential component of humoral ...
Andrea Doni, Marina Sironi, Annalisa Del Prete, Annalisa Del Prete, Fabio Pasqualini, Sonia Valentino, Ivan Cuccovillo, Raffaella Parente, Michela Calvi, Antonella Tosoni, Gianluca Vago, Manuela Nebuloni, Cecilia Garlanda, Cecilia Garlanda, Annunciata Vecchi, Barbara Bottazzi, Alberto Mantovani, Alberto Mantovani, Alberto Mantovani   +18 more
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The mechanism of PDE7B inhibiting the development of hepatocellular carcinoma through oxidative stress

Frontiers in Immunology
BackgroundLiver cancer presents a significant challenge to global health and is currently ranked as the sixth most common form of cancer worldwide. Recent research indicates that phosphodiesterases play a role in various physiological and pathological ...
Yunfeng Luo, Yunfeng Luo, Huaide Gao, Huaide Gao, Jianghua Zhao, Lin Chen, Jianguo Shao, Jianguo Shao, Linling Ju, Linling Ju   +9 more
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Identification of key biomarkers related to fibrocartilage chondrocytes for osteoarthritis based on bulk, single-cell transcriptomic data

Frontiers in Immunology
IntroductionOsteoarthritis (OA) is a prevalent joint disease that severely impacts patients’ quality of life. Due to its unclear pathogenesis and lack of effective therapeutic targets, discovering new biomarkers for OA is essential. Recently, the role of
Bailin Pan, Bailin Pan, Peixiu Yao, Jinjin Ma, Xuanhao Lin, Laixi Zhou, Canzhen Lin, Canzhen Lin, Yufeng Zhang, Bendan Lin, Chuangxin Lin   +10 more
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