Results 11 to 20 of about 109,879 (70)

Molecular and modular intricacies of precision oncology

Frontiers in Immunology
Precision medicine is revolutionizing the world in combating different disease modalities, including cancer. The concept of personalized treatments is not new, but modeling it into a reality has faced various limitations.
Ravneet Chhabra
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Enhancing broadly neutralising antibody suppression of HIV by immune modulation and vaccination

Frontiers in Immunology
Although HIV infection can be managed with antiretroviral drugs, there is no cure and therapy has to be taken for life. Recent successes in animal models with HIV-specific broadly neutralising antibodies (bNAbs) have led to long-term virological ...
Carla Nel, John Frater, John Frater
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Immunological characteristics of a recombinant alphaherpesvirus with an envelope-embedded Cap protein of circovirus

Frontiers in Immunology
IntroductionVariant pseudorabies virus (PRV) is a newly emerged zoonotic pathogen that can cause human blindness. PRV can take advantage of its large genome and multiple non-essential genes to construct recombinant attenuated vaccines carrying foreign ...
Chenhe Lu, Haimin Li, Wenjing Chen, Hui Li, Jiayu Ma, Peng Peng, Yan Yan, Weiren Dong, Yulan Jin, Shiyue Pan, Shaobin Shang, Jinyan Gu, Jiyong Zhou, Jiyong Zhou   +13 more
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The role of macrophages in liver fibrosis: composition, heterogeneity, and therapeutic strategies

Frontiers in Immunology
Macrophages, the predominant immune cells in the liver, are essential for maintaining hepatic homeostasis and responding to liver injury caused by external stressors. The hepatic macrophage population is highly heterogeneous and plastic, mainly comprised
Xiaocao Ma, Xiaocao Ma, Jia Qiu, Jia Qiu, Shubiao Zou, Liling Tan, Tingting Miao   +6 more
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Differential regulation of tissue-resident and blood-derived macrophages in models of autoimmune and traumatic peripheral nerve injury

Frontiers in Immunology
IntroductionThe current study focuses on understanding the functional role of different subsets of endoneurial macrophages in autoimmune polyneuropathies (AP) and traumatic peripheral nerve injury (TPNI), which holds potential for clinical application ...
Alina Sprenger-Svačina, Alina Sprenger-Svačina, Martin K. R. Svačina, Martin K. R. Svačina, Tong Gao, Rodney M. Ritzel, Louise D. McCullough, Kazim A. Sheikh, Gang Zhang   +8 more
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Chimeric antigen receptor T-cell therapy in autoimmune diseases

Frontiers in Immunology
The administration of T cells that have been modified to carry chimeric antigen receptors (CARs) aimed at B cells has been an effective strategy in treating B cell malignancies.
Jie Liu, Yan Zhao, Hai Zhao
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The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI

Frontiers in Immunology
BackgroundTraumatic brain injury (TBI) induces an acute reactive state of microglia, which contribute to secondary injury processes through phagocytic activity and release of cytokines.
Rida Rehman, Rida Rehman, Albrecht Froehlich, Florian olde Heuvel, Lobna Elsayed, Tobias Boeckers, Tobias Boeckers, Markus Huber-Lang, Cristina Morganti-Kossmann, Cristina Morganti-Kossmann, Francesco Roselli, Francesco Roselli   +11 more
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Prevalence, associated factors, barriers and facilitators for oral HIV self-testing among partners of pregnant women attending antenatal care clinics in Wakiso, Uganda

AIDS Research and Therapy
Background Oral HIV self-testing (HIVST) among men is relatively low and still inadequate in Sub-Saharan Africa. Delivering HIVST kits by pregnant women attending antenatal care to their partners is a promising strategy for increasing HIV testing among ...
Lawrence Nduhukyire, Fred C. Semitala, Juliet Ntuulo Mutanda, Dan Muramuzi, Patrick Albert Ipola, Benard Owori, Allen Kabagenyi, Joan Nangendo, Juliana Namutundu   +8 more
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G. vaginalis increases HSV-2 infection by decreasing vaginal barrier integrity and increasing inflammation in vivo

Frontiers in Immunology
IntroductionClinically, a dysbiotic vaginal microbiota (VMB) colonized with anaerobic species such as Gardnerella vaginalis has been linked to increased susceptibility to viral sexually transmitted infections (STIs) such as Herpes Simplex Virus Type 2 ...
Nuzhat Rahman, Nuzhat Rahman, M. Firoz Mian, M. Firoz Mian, Christina L. Hayes, Christina L. Hayes, Aisha Nazli, Aisha Nazli, Charu Kaushic, Charu Kaushic   +9 more
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The role of ACER2 in intestinal sphingolipid metabolism and gastrointestinal cancers

Frontiers in Immunology
Sphingolipids, particularly sphingosine-1-phosphate (S1P), are bioactive lipids involved in regulating cellular processes such as proliferation, apoptosis, inflammation, and tumor progression.
Binggang Liu, Junfeng Zhou, Biao Jiang, Bing Tang, Ting Liu, Pengcheng Lei   +5 more
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