Results 31 to 40 of about 58,013 (257)

Nanobodies: their potential for applications in biotechnology, diagnosis and antiviral properties in Africa; focus on application in agriculture

Biotechnology & Biotechnological Equipment, 2021
Antibodies are key elements in routine immunological tests, having a long history in detection of plant pathogens due to their specificity, reliability and fast performance.
Faith Njeri Njeru, Paul Mbogo Kusolwa
doaj   +1 more source

Renoprotective Effect of the Recombinant Anti-IL-6R Fusion Proteins by Inhibiting JAK2/STAT3 Signaling Pathway in Diabetic Nephropathy

Frontiers in Pharmacology, 2021
Diabetic nephropathy the main reason for end stage renal disease is a common microvascular complication in patients with type 1 and type 2 diabetes. The interleukin-6 (IL-6), acting as a pleiotropic cytokine, play key roles in main autoimmune disorders ...
Nanwen Zhang, Nanwen Zhang, Qingmei Zheng, Yaduan Wang, Juan Lin, He Wang, Rui Liu, Mengru Yan, Xiaofeng Chen, Juhua Yang, Juhua Yang, Xiaole Chen, Xiaole Chen   +12 more
doaj   +1 more source

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state [PDF]

, 2017
Human respiratory syncytial virus (RSV) is the main cause of lower respiratory tract infections in young children. The RSV fusion protein (F) is highly conserved and is the only viral membrane protein that is essential for infection.
Chen, Man, Gilman, Morgan SA, Graham, Barney S, Kabeche, Stephanie C, Kanekiyo, Masaru, Mas, Vicente, McLellan, Jason S, Melero, José A, Rossey, Iebe, Saelens, Xavier, Schepens, Bert, Sedeyn, Koen, Spitaels, Jan, Wrapp, Daniel   +13 more
core   +2 more sources

Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration.

Molecular Immunology, 2023
The bispecific antibody gefurulimab (also known as ALXN1720) was developed to provide patients with a subcutaneous treatment option for chronic disorders involving activation of the terminal complement pathway.
S. Jindal, Dennis Vestergaard Pedersen, Nimish Gera, J. Chandler, Rekha Patel, Alyssa Neill, Josh Cone, Yuchun Zhang, Chao-Xing Yuan, Ellen E. Millman, Dan Carlin, B. Puffer, D. Sheridan, G. R. Andersen, Paul Tamburini   +14 more
semanticscholar   +1 more source

VHH production at the high-luminosity LHC [PDF]

The European Physical Journal Plus, 2019
14 pages, 8 figures, 4 ...
Karl Nordström, Andreas Papaefstathiou
openaire   +4 more sources

VHH CDR-H3 conformation is determined by VH germline usage

Communications Biology, 2023
VHHs or nanobodies are single antigen binding domains originating from camelid heavy-chain antibodies. They are used as diagnostic and research tools and in a variety of therapeutic molecules. Analyzing variable domain structures from llama and alpaca we
Zahra Bahrami Dizicheh, I-Ling Chen, P. Koenig   +2 more
semanticscholar   +1 more source

Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities

mAbs, 2022
Controlled Fab arm exchange (cFAE) has proven to be a generic and versatile technology for the efficient generation of IgG-like bispecific antibodies (DuoBodies or DBs), with several in clinical development and one product, amivantamab, approved by the ...
Desislava Yanakieva, Lukas Pekar, Andreas Evers, Markus Fleischer, Stephan Keller, Dirk Mueller-Pompalla, Lars Toleikis, Harald Kolmar, Stefan Zielonka, Simon Krah   +9 more
doaj   +1 more source

COVID-19 impedimetric biosensor based on polypyrrole nanotubes, nickel hydroxide and VHH antibody fragment: specific, sensitive, and rapid viral detection in saliva samples

Materials Today Chemistry, 2023
SARS-CoV-2 rapid spread required urgent, accurate, and prompt diagnosis to control the virus dissemination and pandemic management. Several sensors were developed using different biorecognition elements to obtain high specificity and sensitivity. However,
A. Santos, A.P. Macedo de Souza Brandão, B. M. Hryniewicz, H. Abreu, L. Bach-Toledo, S. Schuster da Silva, A. Deller, V. Z. Rogerio, D.S. Baêta Rodrigues, P. Hiraiwa, B. Guimarães, L. F. Marchesi, J. Carvalho de Oliveira, D. F. Gradia, F.L.F. Soares, N. Zanchin, C. Camargo de Oliveira, M. Vidotti   +17 more
semanticscholar   +1 more source

Recombinant monovalent llama-derived antibody fragments (VHH) to rotavirus VP6 protect neonatal gnotobiotic piglets against human rotavirus-induced diarrhea [PDF]

, 2013
Group A Rotavirus (RVA) is the leading cause of severe diarrhea in children. The aims of the present study were to determine the neutralizing activity of VP6-specific llama-derived single domain nanoantibodies (VHH nanoAbs) against different RVA strains ...
Alvarado, Carmen, Bok, Karin, Bok, Marina, Chattha, Kuldeep S., Escribano, José M., Fernández, Fernando, Garaicoechea, Lorena Laura, Gómez Sebastián, Silvia, Lasa, Rodrigo, Nuñez, Carmen, Parreño, Gladys Viviana, Saif, Linda J., Vega, Celina Guadalupe, Vlasova, Anastasia N., Wigdorovitz, Andrés   +14 more
core   +3 more sources

Intracellular VHHs to monitor and modulate GPCR signaling

Frontiers in Endocrinology, 2022
Single-domain antibody fragments, also known as VHHs or nanobodies, have opened promising avenues in therapeutics and in exploration of intracellular processes. Because of their unique structural properties, they can reach cryptic regions in their cognate antigen.
Pauline Raynaud, Camille Gauthier, Vinesh Jugnarain, Frédéric Jean-Alphonse, Frédéric Jean-Alphonse, Eric Reiter, Eric Reiter, Gilles Bruneau, Pascale Crépieux, Pascale Crépieux   +9 more
openaire   +5 more sources