Results 31 to 40 of about 42,252 (217)
Llama nanoantibodies with therapeutic potential against human norovirus diarrhea. [PDF]
PLoS ONE, 2015 Noroviruses are a major cause of acute gastroenteritis, but no vaccines or therapeutic drugs are available. Llama-derived single chain antibody fragments (also called VHH) are small, recombinant monoclonal antibodies of 15 kDa with several advantages ...
Lorena Garaicoechea +8 more
doaj +1 more source
Discrete analysis of camelid variable domains: sequences, structures, and in-silico structure prediction [PDF]
PeerJ, 2020 Antigen binding by antibodies requires precise orientation of the complementarity- determining region (CDR) loops in the variable domain to establish the correct contact surface.
Akhila Melarkode Vattekatte +9 more
doaj +2 more sources
Frontiers in Immunology, 2017 The activity of tumor necrosis factor (TNF), a cytokine involved in inflammatory pathologies, can be inhibited by antibodies or trap molecules. Herein, llama-derived variable heavy-chain domains of heavy-chain antibody (VHH, also called Nanobodies™) were
Els Beirnaert +14 more
doaj +1 more source
VHHs as tools for therapeutic protein delivery to the central nervous system
Fluids and Barriers of the CNS, 2022 Background The blood brain barrier (BBB) limits the therapeutic perspective for central nervous system (CNS) disorders. Previously we found an anti-mouse transferrin receptor (TfR) VHH (Nb62) that was able to deliver a biologically active neuropeptide ...
Yessica Wouters +5 more
doaj +1 more source
Lactobacilli as a Vector for Delivery of Nanobodies against Norovirus Infection
Pharmaceutics, 2022 Passive administration of neutralizing antibodies (Abs) is an attractive strategy for the control of gastrointestinal infections. However, an unanswered practical concern is the need to assure the stability of sufficient amounts of orally administered ...
Yoshikazu Yuki +8 more
doaj +1 more source
Development of VHH antibodies against dengue virus type 2 NS1 and comparison with monoclonal antibodies for use in immunological diagnosis. [PDF]
PLoS ONE, 2014 The possibility of using variable domain heavy-chain antibodies (VHH antibodies) as diagnostic tools for dengue virus (DENV) type 2 NS1 protein was investigated and compared with the use of conventional monoclonal antibodies.
Aneela Fatima +7 more
doaj +1 more source
, 2023 (A) Diagram of a standard VHH heterodimer employed in these studies. The VHH heterodimers consisted of two different VHH components (VHH1, VHH2) separated by a spacer ((GGGGS)3), flanked by two E-tags and with an amino terminal E.
Saul Tzipori (37482) +9 more
core +1 more source
A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition [PDF]
, 2013 The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies ...
Ramos, Alejandra +143 more
core +3 more sources
VHH Structural Modelling Approaches: A Critical Review
, 2022 International audienceVHH, i.e., VH domains of camelid single-chain antibodies, are very promising therapeutic agents due to their significant physicochemical advantages compared to classical mammalian antibodies.
Fabrice Gardebien +19 more
core +1 more source