Results 51 to 60 of about 58,013 (257)

DISCOVERY OF NOVEL ANTI-SERUM ALBUMIN VHH AS A BUILDING BLOCK FOR PK PROLONGATION

Antibody Therapeutics, 2023
Background The serum half-life of endogenous albumin is approximately 19 days in humans and 1.5-2.5 days in rodents. This extended half-life in vivo is primarily due to effective recycling upon internalization mediated by the neonatal Fc receptor (FcRn).
Yunying Chen, Xin Lin, Yi Qin, Donghui Wu, Jijie Gu, Siwei Nie   +5 more
semanticscholar   +1 more source

FULLY AI-DRIVEN HUMANOID VHH PHAGE LIBRARY

Antibody Therapeutics, 2023
Abstract Background & Significance VHHs are small and stable fragments that have great potential as therapeutics due to their small size, stability, versatility, and potential for oral administration.
Zhao, Yangyang, Niu, Le, Pan, Xuemin, Ye, Xingda, Yu, Quan, Zhu, Yupeng, Chen, Yile, Sun, Zhiwu, Long, Yunfei, Li, Yi   +9 more
openaire   +1 more source

Lactobacilli as a Vector for Delivery of Nanobodies against Norovirus Infection

Pharmaceutics, 2022
Passive administration of neutralizing antibodies (Abs) is an attractive strategy for the control of gastrointestinal infections. However, an unanswered practical concern is the need to assure the stability of sufficient amounts of orally administered ...
Yoshikazu Yuki, Fanglei Zuo, Shiho Kurokawa, Yohei Uchida, Shintaro Sato, Naomi Sakon, Lennart Hammarström, Hiroshi Kiyono, Harold Marcotte   +8 more
doaj   +1 more source

Silicon-Organic Hybrid (SOH) and Plasmonic-Organic Hybrid (POH) integration [PDF]

, 2015
Silicon-organic hybrid (SOH) and plasmonic-organic hybrid (POH) integration combines organic clectro-optic materials with silicon photonic and plasmonic waveguides, The concept enables fast and power-efficient modulators that support advanced modulation ...
Alloatti, L, Bogaerts, Wim, Bolten, J, Dalton, LR, Elder, DL, Freude, W, Giesecke, AL, Koeber, S, Koehnle, K, Kohl, M, Koos, C, Korn, D, Lauermann, M, Leuthold, J, Melikyan, A, Muehlbrandt, S, Palmer, R, Pfeifle, J, Wahlbrink, T, Weimann, C, Wolf, S   +20 more
core   +3 more sources

GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery

mAbs, 2023
As small and stable high-affinity antigen binders, VHHs boast attractive characteristics both for therapeutic use in various disease indications, and as versatile reagents in research and diagnostics.
Loes van Schie, W. Van Breedam, Charlotte Roels, Bert Schepens, Martin Frank, A. Mehdipour, B. Laukens, W. Nerinckx, Francis Santens, Simon Devos, Iebe Rossey, K. Thooft, S. Vanmarcke, Annelies Van Hecke, X. Saelens, N. Callewaert   +15 more
semanticscholar   +1 more source

Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies

Scientific Reports, 2018
Nucleolin arises as a relevant target for cancer therapy, as it is overexpressed at the surface of cancer and angiogenic endothelial cells thus enabling a dual cellular targeting strategy.
Sofia Romano, Vera Moura, Sérgio Simões, João Nuno Moreira, João Gonçalves   +4 more
doaj   +1 more source

VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins [PDF]

, 2015
Peer reviewedPublisher ...
Clem, Flajnik, Makrides, Marchalonis, Müller   +4 more
core   +3 more sources

Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies

mAbs, 2021
The respiratory virus responsible for coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected nearly every aspect of life worldwide, claiming the lives of over 3.9 million people globally, at the ...
Maxwell A. Stefan, Yooli K. Light, Jennifer L. Schwedler, Peter R. McIlroy, Colleen M. Courtney, Edwin A. Saada, Christine E. Thatcher, Ashlee M. Phillips, Feliza A. Bourguet, Catherine M. Mageeney, Summer A. McCloy, Nicole M. Collette, Oscar A. Negrete, Joseph S. Schoeniger, Dina R. Weilhammer, Brooke Harmon   +15 more
doaj   +1 more source

Evaluation of the Potential Impact of In Silico Humanization on VHH Dynamics

International Journal of Molecular Sciences, 2023
Camelids have the peculiarity of having classical antibodies composed of heavy and light chains as well as single-chain antibodies. They have lost their light chains and one heavy-chain domain.
Carla Martins, J. Diharce, A. Nadaradjane, A. D. de Brevern   +3 more
semanticscholar   +1 more source

Self-Assembling VHH-Elastin-Like Peptides for Photodynamic Nanomedicine [PDF]

Biomacromolecules, 2017
Recombinant llama heavy-chain antibody fragments (VHHs) are promising tools in the field of targeted nanomedicine. 7D12, a VHH against the epidermal growth factor receptor (EGFR) that is overexpressed in various cancers, has been evaluated as an effective cancer-targeting VHH in multiple studies.
Pille, J., van Lith, S.A.M., van Hest, J., van Hest, J., Leenders, W.P.J.   +4 more
openaire   +5 more sources