Results 71 to 80 of about 41,395 (219)

Anti-Idiotypic VHHs and VHH-CAR-T Cells to Tackle Multiple Myeloma: Different Applications Call for Different Antigen-Binding Moieties

International Journal of Molecular Sciences
CAR-T cell therapy is at the forefront of next-generation multiple myeloma (MM) management, with two B-cell maturation antigen (BCMA)-targeted products recently approved.
Heleen Hanssens, Fien Meeus, Emma L. Gesquiere, J. Puttemans, Y. De Vlaeminck, K. De Veirman, Karine Breckpot, N. Devoogdt   +7 more
semanticscholar   +1 more source

Anticuerpos de cadena única de alpaca para la detección de antígenos de Fasciola hepatica

Revista Peruana de Medicina Experimental y Salud Pública, 2018
Objetivo. Producir anticuerpos recombinantes de cadena única de alpaca que se unan con alta afinidad y especificidad al antígeno excretado-secretado (ES) de Fasciola hepatica para el desarrollo de tecnologías nuevas de diagnóstico de fascioliasis humana ...
Teresa Barreto, Yenisey Alfonso, Pierre Lafaye, Maria del Pilar García Lazaro, L. Agueda Perez, Patricia Herrera-Velit, Jose R. Espinoza   +6 more
doaj   +1 more source

Relationship Between Hospital Volume and Outcomes of Minimally Invasive Esophagectomy for Esophageal Cancer: Analysis of the National Clinical Database in Japan

Annals of Gastroenterological Surgery, EarlyView.
According to multivariable analysis conducted using a hierarchical logistic regression model, using VHH as the reference group, the odds ratios for mortality by hospital volume category were as follows: VLH, 2.70 (p < 0.0001); LH, 1.72 (p = 0.052); MH, 1.70 (p = 0.034); and HH, 1.43 (p = 0.173).
Soji Ozawa, Hiraku Kumamaru, Yuko Kitagawa, Kazuo Koyanagi, Junya Oguma, Harushi Udagawa, Hiroaki Miyata, Yasushi Toh, Hisahiro Matsubara   +8 more
wiley   +1 more source

First-in-class trispecific VHH-Fc based antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 and variants

Scientific Reports, 2022
SARS-CoV-2 and its variants have persisted in this ongoing COVID-19 pandemic. While the vaccines have greatly reduced the COVID-19 cases, hospitalizations, and death, about half of the world remain unvaccinated due to various reasons.
Allison Titong, Sachith Gallolu Kankanamalage, Jianbo Dong, Betty C. B. Huang, Nicholas Spadoni, Bo Wang, M. Wright, Keegan L. J. Pham, Anh Le, Yue Liu   +9 more
semanticscholar   +1 more source

Anti-idiotypic VHH mediated environmentally friendly immunoassay for citrinin without mycotoxin

Food and Agricultural Immunology, 2020
Competitive enzyme-linked immunosorbent assay (ELISA) is the most widely used method for rapidly screening of mycotoxins in contaminated food products; however, it involves the use of toxin-protein conjugates as a competitive antigen and toxin standards ...
Liang Xiong, Xueqin Zhang, Yang Xu, Yanping Li, Deguang Liu, Zhui Tu, Qinghua He   +6 more
doaj   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

FXII contact activation is dependent on binding through two unique patches in its EGF-1 domain and can be prevented by (VHH) targeting.

Journal of Thrombosis and Haemostasis
BACKGROUND Factor XII (FXII) triggers contact activation by binding to foreign surfaces, with the EGF-1 domain being the primary binding site. Blocking FXII surface-binding might hold therapeutic value to prevent medical device-induced thrombosis ...
R. Frunt, H. El Otmani, Simone Smits, C. Clark, Coen Maas   +4 more
semanticscholar   +1 more source

VHH Structural Modelling Approaches: A Critical Review

International Journal of Molecular Sciences, 2022
VHH, i.e., VH domains of camelid single-chain antibodies, are very promising therapeutic agents due to their significant physicochemical advantages compared to classical mammalian antibodies.
Poonam Vishwakarma, Akhila Melarkode Vattekatte, Nicolas K. Shinada, J. Diharce, Carla Martins, F. Cadet, F. Gardebien, C. Etchebest, A. Nadaradjane, A. D. de Brevern   +9 more
semanticscholar   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Functional Divergence in the Affinity and Stability of Non-Canonical Cysteines and Non-Canonical Disulfide Bonds: Insights from a VHH and VNAR Study

International Journal of Molecular Sciences
Single-domain antibodies, including variable domains of the heavy chains of heavy chain-only antibodies (VHHs) from camelids and variable domains of immunoglobulin new antigen receptors (VNARs) from cartilaginous fish, show the therapeutic potential of ...
Mingce Xu, Zheng Zhao, Penghui Deng, Mengsi Sun, Cookson K. C. Chiu, Yujie Wu, Hao Wang, Yunchen Bi   +7 more
semanticscholar   +1 more source