Results 71 to 80 of about 42,252 (217)
Anti-VP6 VHH: An Experimental Treatment for Rotavirus A-Associated Disease. [PDF]
PLoS ONE, 2016 Species A Rotaviruses (RVA) remain a leading cause of mortality in children under 5 years of age. Current treatment options are limited. We assessed the efficacy of two VP6-specific llama-derived heavy chain antibody fragments (VHH) -2KD1 and 3B2- as an ...
Lucía Maffey +4 more
doaj +1 more source
A novel single-domain antibody multimer that potently neutralizes tetanus neurotoxin
Vaccine: X, 2021 Tetanus antitoxin, produced in animals, has been used for the prevention and treatment of tetanus for more than 100 years. The availability of antitoxins, ethical issues around production, and risks involved in the use of animal derived serum products ...
Hans de Smit +4 more
doaj +1 more source
Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity
VIEW, EarlyView.Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin +3 more
wiley +1 more source
Enhancement of toxin- and virus-neutralizing capacity of single-domain antibody fragments by N-glycosylation [PDF]
, 2009 Single-domain antibody fragments (VHHs) have several beneficial properties as compared to conventional antibody fragments. However, their small size complicates their toxin- and virus-neutralizing capacity.
Fijten, H.P.D. +5 more
core +1 more source
Single-Domain Vhh Antibodies as Protein Stabilization Modules [PDF]
, 2020 VHH domains are the antigen-binding units found in heavy-chain-only antibodies from the Camelidae family (e.g., camels and llamas). They are considered a unique minimalist antibody scaffold due to the lack of a variable light chain domain. Despite having
Mostafa, Nourhan Mohamed Disouky
core +1 more source
VIEW, EarlyView.Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley +1 more source
Characterizing VHH Domains as Stabilization and Oligomeric Control Modules [PDF]
, 2023 The biophysical properties of the VHH domain from heavy-chain-only antibodies obtained from the Camelidae family has expanded opportunities for novel antibody applications.
Patel, Niyati
core +1 more source
Advances in deep‐tissue fluorescence imaging through optical clearing: A review
VIEW, EarlyView.Optical clearing refers to techniques that are used to improve the optical transparency of biological tissues. Optical clearing enables imaging of deeper lying tissues as well as 3D volumetric imaging of whole organs. This review examines reports on the integration of optical clearing with advanced fluorescence imaging techniques, with particular ...
Alaka Pramod +4 more
wiley +1 more source
Double digestion and purification of VHH antibodies.
, 2014 (A) Agarose gel electrophoresis of VHH antibodies double digested with BamHI and HindIII. Upper bands of 4500 bp correspond to vector pCANTAB5E whereas lower bands of 400 bp correspond to VHH fragments of P2 (lane 1), P9 (lane 2), P10 (lane 3), P13 (lane
Jufang Wang (91185) +7 more
core +1 more source
Schematic of the modular system for VHH-mediated BBB transcytosis and target engagement.
, 2022 Module 1: anti-mTfR VHH for RMT across BBB. Module 2: neurotensin peptide (NT) for rapid assessment of in vivo target engagement via measurement of hypothermia.
David L. Brody (11440360) +2 more
core +1 more source