Results 71 to 80 of about 38,752 (185)

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Characterization of plant produced VHH antibodies against cobra venom toxins for antivenom therapy

Biotechnology Reports
Cobra (Naja kaouthia) venom contains many toxins including α-neurotoxin (αNTX) and phospholipase A2 (PLA2), which can cause neurodegeneration, respiratory failure, and even death.
Sarocha Vitayathikornnasak, Kaewta Rattanapisit, Ashwini Malla, Pipob Suwanchaikasem, Richard Strasser, Narach Khorattanakulchai, Kanokporn Pothisamutyothin, Wanatchaporn Arunmanee, Waranyoo Phoolcharoen   +8 more
doaj   +1 more source

Botulinum Neurotoxins and Botulism: A Novel Therapeutic Approach

Toxins, 2011
Specific treatment is not available for human botulism. Current remedial mainstay is the passive administration of polyclonal antibody to botulinum neurotoxin (BoNT) derived from heterologous species (immunized animal or mouse hybridoma) together with ...
Wanpen Chaicumpa, Jeeraphong Thanongsaksrikul   +1 more
doaj   +1 more source

Comparative Morphology and Homology of the Hyoid Apparatus and Associated Muscles in Beloniform Fishes (Teleostei: Atherinomorpha)

Journal of Morphology, Volume 287, Issue 8, August 2026.
Homology of the branchiostegals rays in atherinomorph fishes demonstrated by the position of the rays relative to the interhyoideus muscle. In beloniform outgroups, above, the two groups of branchiostegal rays are separated by the interhyoideus. In beloniform fishes, below, only one group of branchiostegal rays is present.
Daniel N. Lumbantobing, Lynne R. Parenti
wiley   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Vibrio Community Structure Shapes the Diversity of Carbenicillin‐Hydrolysing Class A β‐Lactamase Circulating in European Coastal Environments

Environmental Microbiology, Volume 28, Issue 8, August 2026.
Vibrio communities shape carbenicillinase diversity in European coasts. Sediments serve as reservoirs of antibiotic‐resistant Vibrio alginolyticus, which can move into the water column and accumulate in bivalves. This spreads β‐lactamase resistance and raises human exposure risks to antibiotic‐resistant pathogenic Vibrio, especially as higher seawater ...
Berenice Reggiardo, Jamal Saad, Marie‐Agnès Travers, Yannick Labreuche, David Goudenège, Eve Toulza, Coralie Broquard, Karl B. Andree, Julia Mougin, Nicolas Argenta, Gaëlle Courtay, Juliette Pouzadoux, Océane Romatif, Audrey Caro, Dolors Furones, Luigi Vezzulli, Gianluca Corno, Andrea Di Cesare, Ignasi Gairin, Bruno Petton, K. Mathias Wegner, Caroline Montagnani, Viviane Boulo, Delphine Destoumieux‐Garzón   +23 more
wiley   +1 more source

Inhibition of tau neuronal internalization using anti-tau single domain antibodies

Nature Communications
In Alzheimer’s disease, tau pathology spreads across brain regions as the disease progresses. Intracellular tau can be released and taken up by nearby neurons.
Clément Danis, Elian Dupré, Thomas Bouillet, Marine Denéchaud, Camille Lefebvre, Marine Nguyen, Justine Mortelecque, François-Xavier Cantrelle, Jean-Christophe Rain, Xavier Hanoulle, Morvane Colin, Luc Buée, Isabelle Landrieu   +12 more
doaj   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Left Atrial Coupling Indexes as New Mortality Predictors in Chronic Chagas Disease

Echocardiography, Volume 43, Issue 8, August 2026.
Echocardiographic left atrial coupling indexes are promising prognostic markers of dismal outcome in Chagas disease. They were associated with all‐cause mortality independent from age, sex, and echocardiographic indexes, including LV ejection fraction, supporting their potential clinical relevance.
Roberto M. Saraiva, Mauro Felippe F. Mediano, Henrique H. Veloso, Marcelo T. Holanda, Andréa R. Costa   +4 more
wiley   +1 more source

A modified single-domain antibody candidate for the treatment of botulism caused by botulinum toxin type A

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. Currently, the primary treatment method for botulism is the use of botulinum antitoxin, which causes a number of side effects, including allergic reactions.
A. A. Derkaev, E. I. Ryabova, I. B. Esmagambetov, D. V. Shcheblyakov, A. N. Noskov, I. D. Vinogradova, V. V. Prokofiev, D. S. Polyansky, D. Y. Logunov, A. L. Gintsburg   +9 more
doaj   +1 more source