Results 61 to 70 of about 58,013 (257)

AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model

EMBO Molecular Medicine, 2022
Single domain antibodies (VHHs) are potentially disruptive therapeutics, with important biological value for treatment of several diseases, including neurological disorders.
Marika Marino, Lujia Zhou, M. Y. Rincon, Z. Callaerts‐Vegh, Jens Verhaert, Jérôme Wahis, Eline Creemers, L. Yshii, Keimpe D. Wierda, T. Saito, C. Marneffe, I. Voytyuk, Y. Wouters, M. Dewilde, S. Duqué, C. Vincke, Yona Levites, T. Golde, T. Saido, S. Muyldermans, A. Liston, B. de Strooper, M. Holt   +22 more
semanticscholar   +1 more source

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. [PDF]

, 2020
Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed. Single-domain antibodies (VHH) have been examined as a countermeasure for BoNT because of their high ...
Jin, Rongsheng, Lam, Kwok-Ho, McNutt, Patrick M, Ondeck, Celinia, Perry, Kay, Shoemaker, Charles B, Tremblay, Jacqueline M, Vazquez-Cintron, Edwin, Webb, Robert P   +8 more
core  

Unions: Rent Extractors or Creators? [PDF]

, 2004
Unions: Rent Extractors or ...
Aidt, Toke S., Sena, Vania
core   +1 more source

Highly potent multivalent VHH antibodies against Chikungunya isolated from an alpaca naïve phage display library

Journal of Nanobiotechnology, 2022
Background Chikungunya virus (CHIKV) is a re-emerged mosquito-borne alphavirus that can cause musculoskeletal diseases, imposing a substantial threat to public health globally.
Qianlin Li, Fuqiang Zhang, Yi Lu, Huan Hu, Jin Wang, Cheng Guo, Q. Deng, Conghui Liao, Qin Wu, T. Hu, Zeliang Chen, Jiahai Lu   +11 more
semanticscholar   +1 more source

A Model of Russia's "Virtual Economy" [PDF]

, 2000
The Russian Economy has evolved into a hybrid form, a partially monetized quasi-market system that has been called the virtual economy. In the virtual economy, barter and non-monetary transactions play a key role in transferring value from the ...
Ericson, Richard E., Ickes, Barry W.
core   +1 more source

Orally active bivalent VHH construct prevents proliferation of F4+ enterotoxigenic Escherichia coli in weaned piglets

iScience, 2022
Summary A major challenge in industrial pig production is the prevalence of post-weaning diarrhea (PWD) in piglets, often caused by enterotoxigenic Escherichia coli (ETEC).
B. K. Fiil, S. Thrane, Michael Pichler, Tiia Kittilä, Line Ledsgaard, Shirin Ahmadi, G. M. Maigaard Hermansen, L. Jelsbak, C. Lauridsen, S. Brix, A. H. Laustsen   +10 more
semanticscholar   +1 more source

Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions

mAbs
The development of bispecific antibodies that bind at least two different targets relies on bringing together multiple binding domains with different binding properties and biophysical characteristics to produce a drug-like therapeutic.
Michael J. Mullin, J. McClory, W. Haynes, Justin Grace, Nathan J. Robertson, G. van Heeke   +5 more
semanticscholar   +1 more source

Novel CAR-T Cells Specifically Targeting Nectin4 Exhibit Effective Anti-Tumor Efficacy in Bladder Cancer Cell Lines

BIO Integration
Background: Bladder cancer (BLCA) is one of the most common malignancies and the second most frequent urogenital tract tumor. Cell and gene therapy, which offer many advantages in treating BLCA, are urgently needed.
Jinping Niu, Guodi Liu, Sai Zhang, Chengnan Xu, Ziwen Xu, Xingyuan Ma, Xiaoli Tian, Wenyun Zheng   +7 more
doaj   +1 more source

Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants

Frontiers in Immunology, 2022
Anti-COVID antibody therapeutics have been developed but not widely used due to their high cost and escape of neutralization from the emerging variants.
Qi Li, Fiachra Humphries, Roxie C. Girardin, Aaron Wallace, Monir Ejemel, Alla Amcheslavsky, Conor T. McMahon, Zachary A. Schiller, Zepei Ma, John Cruz, Alan P. Dupuis, Anne F. Payne, Arooma Maryam, Nese Kurt Yilmaz, Kathleen A. McDonough, Brian G. Pierce, Celia A. Schiffer, Andrew C. Kruse, Mark S. Klempner, Lisa A. Cavacini, Katherine A. Fitzgerald, Yang Wang   +21 more
doaj   +1 more source

Asymptotic expansions for some semiparametric program evaluation estimators [PDF]

, 2001
We investigate the performance of a class of semiparametric estimators of the treatment effect via asymptotic expansions. We derive approximations to the first two moments of the estimator that are valid to 'second order'.
Ichimura, H., Linton, O.
core   +1 more source