Results 61 to 70 of about 42,252 (217)
A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control
Advanced Science, EarlyView.Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias +23 more
wiley +1 more source
Advanced Science, EarlyView.Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke +10 more
wiley +1 more source
Co-expression of Factor VIII with anti-FVIII Camelid antibody ligands: Effect on expression levels of bio-therapeutic FVIII [PDF]
, 2015 Production of recombinant FVIII, the protein that is missing or dysfunctional in haemophilia A patients, is highly inefficient compared to other recombinant clotting factors such as FIX.
Tolley, Caroline
core
Construction of Synthetic VHH Libraries in Ribosome Display Format
, 2023 International audienceSingle-domain antibodies, or VHH, represent an attractive molecular basis to design affinity proteins with favorable properties.
Pecorari, Frédéric, Guilbaud, Audrey
core +1 more source
Cytometry Part B: Clinical Cytometry, EarlyView.Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley +1 more source
Summary of VHH characterization data.
, 2012 AVHH epitopes are named arbitrarily based on their inability to compete with the binding of VHHs recognizing other epitopes.BSubunit recognition was assessed by ELISA with purified BoNT light chain (Lc) or heavy chain (Hc).
Saul Tzipori (37482) +11 more
core +1 more source
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy +7 more
wiley +2 more sources
Steady‐State and Dynamic Behavior of Geometry‐Tunable Microfluidic Passive Flow Regulators
Small, EarlyView.Passive microfluidic flow regulators exhibit geometry‐dependent dynamic behavior, where channel width governs the resistance–compliance interactions within the system. Narrow channels produce faster responses with higher bandwidth, while wider channels yield slower responses and stronger attenuation.
Huy Hoang Vu +4 more
wiley +1 more source
Microneutralization and antibody competition of RSV-specific VHH.
, 2013 Monovalent VHH neutralizing RSV Long strain, subtype A. Neutralization is expressed in percentage as compared to controls with irrelevant VHH, plotted against the concentrations of VHH in molar (M) (A).
Steven Van Gucht (353869) +15 more
core +1 more source
Nanobody and Its Therapeutic Applications
Journal of Mazandaran University of Medical Sciences, 2018 Background and purpose: Monoclonal antibodies market has grown since approval of Muromonab-CD3 (trade name Orthoclone OKT3) in 1986 as immuno- suppressor.
Maryam Darvish
doaj