Results 81 to 90 of about 42,252 (217)

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

Impact of Interprofessional Simulation on Health Students' Self‐Reported Attitudes Towards Older Adults: A Pre‐Post Questionnaire‐Based Study

European Journal of Dental Education, EarlyView.
ABSTRACT Background Aging simulation may promote the knowledge and skills of healthcare providers and students. We hypothesized that interprofessional simulation related to the care of older adults could influence healthcare students' self‐reported attitudes towards older patients. Materials and Methods Interprofessional role‐play simulations dedicated
Sophie Prissette, Vanessa Bloch, Olivier Bourdon, Sandrine Masseron, Aline Hartmann, Marie‐Violaine Berteretche, Hélène Van Hille, Sophie Leignel, Nejma Batikhy, Teddy Jametal, Adeline Braud   +10 more
wiley   +1 more source

: VHH against DARC [PDF]

, 2010
International audienceFy blood group antigens are carried by the Duffy antigen receptor for chemokines (DARC), a red cells receptor for Plasmodium vivax broadly implicated in human health and diseases. Recombinant VHHs, or nanobodies, the smallest intact
Grodecka, Magdalena, Bertrand, Olivier, Picot, Julien, Cochet, Sylvie, Le van Kim, Caroline, Czerwinski, Marcin, Udomsangpetch, Rachanee, Smolarek, Dorota, Hassanzadeh-Ghassabeh, Gholamreza, Hattab, Claude, de Brevern, Alexandre, Wasniowska, Kazimiera, De Brevern, Alexandre G., Colin, Yves, Gutiérrez, Carlos, Muyldermans, Serge   +15 more
core   +1 more source

FVIIIa Mimetics: New Approaches and Next‐Generation Initiatives

Haemophilia, EarlyView.
ABSTRACT Emicizumab has revolutionized hemophilia A care, yet limitations regarding the “ceiling” of hemostatic efficacy (equivalent to mild hemophilia) and global access persist. This review critically examines two distinct paradigms shaping the future of care: Innovation and Access. Regarding innovation, we synthesize the latest clinical data on next‐
Tadashi Matsushita, Keiji Nogami, Chandrakala Shanmukhaiah   +2 more
wiley   +1 more source

Box plots of the analysis of non-classical VHH clones.

, 2016
a The percentage of Trp-clones and Arg-clones (the clones whose first AA of FR4 are Trp and Arg) for classical VHH, non-classical VHH and VH(3) family clones.
Ruxue Lu (3097914), Naibo Yang (3097908), Mengying He (593736), Wei Zhang (405), Yanrui Ye (3097917), Jian Wang (5901), Zhe Ren (558949), Changxi Wang (658966), Xiaobo Duan (272150), Xiao Liu (65413), Xinyang Li (1543561), Longfei Fu (3097911), Kai Yang (73590), Huanming Yang (5905), Changjiang Zhang (360290), Chao Nie (418889), Jinghua Wu (436901), Wen Tan (102776)   +17 more
core   +1 more source

Structural details of designed VHH-72 mutations.

, 2022
(A) Sequence mapping of ADAPT-designed 13 single mutations tested experimentally, which are shown under the sequence of the parent VHH-72 (Kabat numbering shown on top). Mutant hits validated experimentally are bolded.
Mélanie Duchesne (12322711), Matthew Stuible (12322702), Marie Parat (12322705), Nazanin Rohani (228955), Traian Sulea (1549372), Yves Durocher (448036), Pierre Plante (21114), Yuneivy Cepero Donates (12322708), Jason Baardsnes (580188), Anh Tran (2494153), Guneet Kour (12322714)   +10 more
core   +1 more source

Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform

mAbs, 2020
Here, we report the characterization of a VHH-derived IgG-like bi- and trispecific antibody platform that essentially relies on the replacement of the VH and VL regions of a conventional antibody by two independently functioning VHH domains. Consequently,
Lukas Pekar, Michael Busch, Bernhard Valldorf, Steffen C. Hinz, Lars Toleikis, Simon Krah, Stefan Zielonka   +6 more
doaj   +1 more source

The TaRNS4–TaPP2C10 module regulates wheat resistance to stripe rust through RNA degradation and MAPK cascades

Journal of Integrative Plant Biology, EarlyView.
In wheat, phosphorylation of the S‐like RNase TaRNS4 mediated by the kinase TaRLK5 promotes its degradation of Puccinia striiformis f. sp. tritici RNA in the apoplast, enhancing resistance to stripe rust. TaRNS4 can hijack phosphatase TaPP2C10 to relieve its dephosphorylation of TaMAPK6, thereby activating MAPK‐mediated immune responses. ABSTRACT RNase
Qiao Wang, Hongxu Zuo, Mantong Lu, Ying Li, Juan Li, Ming Qin, Peng Cheng, Qiang Li, Baotong Wang   +8 more
wiley   +1 more source

Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection

Frontiers in Immunology, 2019
Lower respiratory tract infections, such as infections caused by influenza A viruses, are a constant threat for public health. Antivirals are indispensable to control disease caused by epidemic as well as pandemic influenza A.
Dorien De Vlieger, Dorien De Vlieger, Dorien De Vlieger, Katja Hoffmann, Inge Van Molle, Inge Van Molle, Wim Nerinckx, Wim Nerinckx, Lien Van Hoecke, Lien Van Hoecke, Marlies Ballegeer, Marlies Ballegeer, Marlies Ballegeer, Sarah Creytens, Sarah Creytens, Sarah Creytens, Han Remaut, Han Remaut, Hartmut Hengel, Bert Schepens, Bert Schepens, Xavier Saelens, Xavier Saelens, Xavier Saelens   +23 more
doaj   +1 more source

A functionally distinct HPA‐1a‐specific alloantibody associated with fetal/neonatal alloimmune thrombocytopenia that activates platelets via FcγRIIa

Transfusion, EarlyView.
Abstract Background Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal alloantibodies directed against fetal platelet antigens, most commonly human platelet antigen‐1a (HPA‐1a). These antibodies mediate platelet destruction and can lead to fetal and neonatal thrombocytopenia severe enough to cause life‐threatening organ bleeds ...
Huiying Zhi, Cathy Paddock, Daniel Villalobos‐Garcia, Janita Oosterhoff, Heng Zhang, Gestur Vidarsson, Renren Wen, Jieqing Zhu, Debra Newman, Peter J Newman   +9 more
wiley   +1 more source