Results 81 to 90 of about 41,395 (219)
Molecular Pharmaceutics, 2022 Hypoxic areas are present in the majority of solid tumors, and hypoxia is associated with resistance to therapies and poor outcomes. A transmembrane protein that is upregulated by tumor cells that have adapted to hypoxic conditions is carbonic anhydrase ...
S. V. van Lith +10 more
semanticscholar +1 more source
Chemistry – A European Journal, EarlyView.The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik +3 more
wiley +1 more source
mAbsThe bispecific antibody tarperprumig (ALXN1820) was developed as a treatment option for diseases involving dysregulated complement alternative pathway (AP) activity that could be administered in small volumes, either subcutaneously or intravenously ...
Paul Tamburini +8 more
semanticscholar +1 more source
VHH-Based Bispecific Antibodies Targeting Cytokine Production [PDF]
Frontiers in Immunology, 2017 Proinflammatory cytokines, such as TNF, IL-6, and IL-1, play pathogenic roles in multiple diseases and are attractive targets for biologic drugs. Because proinflammatory cytokines possess non-redundant protective and immunoregulatory functions, their systemic neutralization carries the potential for unwanted side effects.
Maxim A. Nosenko +18 more
openaire +3 more sources
Nanobody and Its Therapeutic Applications
Journal of Mazandaran University of Medical Sciences, 2018 Background and purpose: Monoclonal antibodies market has grown since approval of Muromonab-CD3 (trade name Orthoclone OKT3) in 1986 as immuno- suppressor.
Maryam Darvish
doaj
A novel single-domain antibody multimer that potently neutralizes tetanus neurotoxin
Vaccine: X, 2021 Tetanus antitoxin, produced in animals, has been used for the prevention and treatment of tetanus for more than 100 years. The availability of antitoxins, ethical issues around production, and risks involved in the use of animal derived serum products ...
Hans de Smit +4 more
doaj +1 more source
Cytometry Part B: Clinical Cytometry, EarlyView.Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley +1 more source
Single VHH-directed BCMA CAR-T cells cause remission of relapsed/refractory multiple myeloma
Leukemia, 2021 Chimeric antigen receptor T (CAR-T) cells have shown remarkable effects in treating hematological malignancies [1, 2]. Typically, the antigen recognition domain of CAR-T cells is a single-chain variable fragment (scFv) linked to a costimulatory domain ...
Lu Han +16 more
semanticscholar +1 more source
PCR detection of hemolysin (vhh) gene in Vibrio harveyi
The Journal of General and Applied Microbiology, 2004 The Vibrio harveyi hemolysin gene (vhh), which encodes for a virulence factor involved in pathogenicity to fish and shellfish species, may be targeted for species detection or strain differentiation. Primers designed for this gene were used in detection studies of V. harveyi strains from various hosts.
Conejero, Mia Judith U. +1 more
openaire +3 more sources
Global analysis of VHHs framework regions with a structural alphabet [PDF]
Biochimie, 2016 The VHHs are antigen-binding region/domain of camelid heavy chain antibodies (HCAb). They have many interesting biotechnological and biomedical properties due to their small size, high solubility and stability, and high affinity and specificity for their antigens. HCAb and classical IgGs are evolutionary related and share a common fold.
Floriane Noël +2 more
openaire +3 more sources