Results 81 to 90 of about 38,752 (185)

Characterization of HexDetect and HexBlock VHHs

, 2023
Nuförtiden används antikroppar ofta i terapier och diagnostik. Antikroppar kan förstärka immunsvar och stödja kroppens eget försvar mot patogener och cancer. Klassiska vägar för antikroppar att göra det är antikroppsberoende cellulär cytotoxicitet (ADCC) eller antikroppsberoende cellulär fagocytos (ADCP). En annan naturlig försvarsmekanism
openaire   +1 more source

Neutralization of the Pandemic Influenza A/H1N1 Virus with Lama glama Humanized Nanobodies (VHH)

Antibodies
Background/Objetives: Nanobodies (VHH) have become an excellent tool for diagnosis, therapy, and research since VHH shows a high capability of recognizing and neutralizing antigens.
Zeila Yazmín Páez-Hernández, Jose Luis Stephano-Hornedo, Jose Alberto Bolaños-Prats, Iván Córdova-Guerrero, Mariana Macías-Alonso, Joaquín G. Marrero, Angel Pulido Capiz, Victor García González   +7 more
doaj   +1 more source

Transdermal Administration of Nanobody Molecules using Hydrogel‐Forming Microarray Patch Technology: A Unique Delivery Approach

Macromolecular Materials and Engineering
Nanobody molecules, derived from heavy‐chain only antibodies in camelids, represent the next generation of biotherapeutics. In addition to low immunogenicity, high stability, and potency, their single‐domain format facilitates the construction of ...
Aaron R. J. Hutton, Melissa Kirkby, Tom Van Bogaert, Peter Casteels, Christelle Nonne, Veronique De Brabandere, Ortwin Van deVyver, Lalit K. Vora, Ismaiel A. Tekko, Helen O. McCarthy, Ryan F. Donnelly   +10 more
doaj   +1 more source

Biparatopic anti-PCSK9 antibody enhances the LDL-uptake in HepG2 cells

Scientific Reports
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target to reduce lipids. In 2020, we reported a chimeric camelid-human heavy chain antibody VHH-B11-Fc targeting PCSK9.
Xinyang Li, Wei Zhang, Yu Shu, Rui Huo, Chengyang Zheng, Qi Qi, Pengfei Fu, Jie Sun, Yuhuan Wang, Yan Wang, Juxu Lu, Xiangjie Zhao, Guoyou Yin, Qingqing Wang, Jun Hong   +14 more
doaj   +1 more source

Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau seeding in Alzheimer's disease. [PDF]

J Biomed Sci
Oosterlynck M, Fichter L, Leroux E, Eddarkaoui S, Bouillet T, Lefebvre C, Nguyen M, Maurage CA, Accart B, Dupré E, Landrieu I, Danis C, Lehmann S, Vialaret J, Buée L, Hirtz C, Colin M.   +16 more
europepmc   +1 more source

The Promise of Single-Domain Antibodies as Ocular Therapeutics: A Narrative Review. [PDF]

Int J Mol Sci
Jakobsen TS, Kaptain K, Pedersen K, Adsersen RL, Aagaard L, Askou AL, Corydon TJ.   +6 more
europepmc   +1 more source

Functional Suitability Evaluation of Radioimmunoconjugates of Nanobodies against PD-L1 and HER2/neu for Tumor Theranostics. [PDF]

Sovrem Tekhnologii Med
Avrov KO, Shatik SV, Shashkova OA, Pinevich AA, Terekhina LA, Gryazeva IV, Zaitsev VV, Berlina MA, Stanzhevsky AA, Samoylovich MP.   +9 more
europepmc   +1 more source

Potent neutralization and therapeutic efficacy of bovine rotavirus-specific VHH antibodies in infected calves. [PDF]

Vet Res
Zhao Q, Gao M, Li P, Wang B, Li B, Rile G, Du C, Wang J, Wang H, Mei J, Zhang S, Bao F.   +11 more
europepmc   +1 more source

Parallelised Cloning, Mammalian Cell Expression, and Purification of Nanobodies Identified by Phage Display. [PDF]

Bio Protoc
Campaigne HA, Parker KL, Owens RJ, Eyssen LE.   +3 more
europepmc   +1 more source

A ZNF-nanobody fusion reveals SUMOylation-dependent changes in p53 protein localization. [PDF]

iScience
Bouchard AY, Cabana VC, Plamondon J, Li C, Vivet AJI, Mader S, Thibault P, Lussier MP, Cappadocia L.   +8 more
europepmc   +1 more source