Results 101 to 110 of about 41,395 (219)

A modified single-domain antibody candidate for the treatment of botulism caused by botulinum toxin type A

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. Currently, the primary treatment method for botulism is the use of botulinum antitoxin, which causes a number of side effects, including allergic reactions.
A. A. Derkaev, E. I. Ryabova, I. B. Esmagambetov, D. V. Shcheblyakov, A. N. Noskov, I. D. Vinogradova, V. V. Prokofiev, D. S. Polyansky, D. Y. Logunov, A. L. Gintsburg   +9 more
doaj   +1 more source

Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform

mAbs, 2020
Here, we report the characterization of a VHH-derived IgG-like bi- and trispecific antibody platform that essentially relies on the replacement of the VH and VL regions of a conventional antibody by two independently functioning VHH domains. Consequently,
Lukas Pekar, Michael Busch, Bernhard Valldorf, Steffen C. Hinz, Lars Toleikis, Simon Krah, Stefan Zielonka   +6 more
doaj   +1 more source

Impact of Interprofessional Simulation on Health Students' Self‐Reported Attitudes Towards Older Adults: A Pre‐Post Questionnaire‐Based Study

European Journal of Dental Education, EarlyView.
ABSTRACT Background Aging simulation may promote the knowledge and skills of healthcare providers and students. We hypothesized that interprofessional simulation related to the care of older adults could influence healthcare students' self‐reported attitudes towards older patients. Materials and Methods Interprofessional role‐play simulations dedicated
Sophie Prissette, Vanessa Bloch, Olivier Bourdon, Sandrine Masseron, Aline Hartmann, Marie‐Violaine Berteretche, Hélène Van Hille, Sophie Leignel, Nejma Batikhy, Teddy Jametal, Adeline Braud   +10 more
wiley   +1 more source

Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection

Frontiers in Immunology, 2019
Lower respiratory tract infections, such as infections caused by influenza A viruses, are a constant threat for public health. Antivirals are indispensable to control disease caused by epidemic as well as pandemic influenza A.
Dorien De Vlieger, Dorien De Vlieger, Dorien De Vlieger, Katja Hoffmann, Inge Van Molle, Inge Van Molle, Wim Nerinckx, Wim Nerinckx, Lien Van Hoecke, Lien Van Hoecke, Marlies Ballegeer, Marlies Ballegeer, Marlies Ballegeer, Sarah Creytens, Sarah Creytens, Sarah Creytens, Han Remaut, Han Remaut, Hartmut Hengel, Bert Schepens, Bert Schepens, Xavier Saelens, Xavier Saelens, Xavier Saelens   +23 more
doaj   +1 more source

FVIIIa Mimetics: New Approaches and Next‐Generation Initiatives

Haemophilia, EarlyView.
ABSTRACT Emicizumab has revolutionized hemophilia A care, yet limitations regarding the “ceiling” of hemostatic efficacy (equivalent to mild hemophilia) and global access persist. This review critically examines two distinct paradigms shaping the future of care: Innovation and Access. Regarding innovation, we synthesize the latest clinical data on next‐
Tadashi Matsushita, Keiji Nogami, Chandrakala Shanmukhaiah   +2 more
wiley   +1 more source

A new catfish species of Microcambeva Costa & Bockmann, 1994 (Siluriformes: Trichomycteridae) from southern Brazil, with a redescription of M. ribeirae Costa, Lima & Bizerril, 2004

Journal of Fish Biology, EarlyView.
Abstract Among the few species of Microcambeva reported as occurring in more than one hydrographic basin, M. ribeirae has been previously listed from both the Ribeira de Iguape and the Guaraqueçaba basins. However, morphological and molecular analyses revealed that the specimens from Guaraqueçaba represent a new species, which is described in this ...
Lucas S. de Medeiros, Igor C. A. Souto‐Santos, Paulo A. Buckup, Juliano Ferrer, Vinicius J. C. Reis, Mario de Pinna, Sergio M. Q. Lima   +6 more
wiley   +1 more source

Use, Applications and Mechanisms of Intracellular Actions of Camelid VHHs

, 2018
The discovery of heavy-chain-only antibodies (HCAbs) in camelids and sharks led to the rise of a new research field in which single-domain antibodies are used for various applications. Single-domain antibodies are the antigen-binding fragments derived from HCAbs showing several beneficial properties (e.g., small size, specificity, stability under ...
Steels, Anneleen, Bertier, Laurence, Gettemans, Jan   +2 more
openaire   +2 more sources

Enhancement of Polymeric Immunoglobulin Receptor Transcytosis by Biparatopic VHH

PLoS ONE, 2011
The polymeric immunoglobulin receptor (pIgR) ensures the transport of dimeric immunoglobulin A (dIgA) and pentameric immunoglobulin M (pIgM) across epithelia to the mucosal layer of for example the intestines and the lungs via transcytosis. Per day the human pIgR mediates the excretion of 2 to 5 grams of dIgA into the mucosa of luminal organs.
Chris D Emmerson, Els J van der Vlist, Myrthe R Braam, Peter Vanlandschoot, Pascal Merchiers, Hans J W de Haard, C Theo Verrips, Paul M P van Bergen en Henegouwen, Edward Dolk   +8 more
openaire   +4 more sources

Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C.

PLoS ONE, 2012
Many of the neutralising antibodies, isolated to date, display limited activities against the globally most prevalent HIV-1 subtypes A and C. Therefore, those subtypes are considered to be an important target for antibody-based therapy.
Nika Strokappe, Agnieszka Szynol, Marlèn Aasa-Chapman, Andrea Gorlani, Anna Forsman Quigley, David Lutje Hulsik, Lei Chen, Robin Weiss, Hans de Haard, Theo Verrips   +9 more
doaj   +1 more source

Outbreaks of Granulomatous Disease Associated With Vibrio harveyi Infection in Grouper (Epinephelus fuscoguttatus × E. lanceolatus) Aquaculture in Taiwan

Journal of Fish Diseases, EarlyView.
ABSTRACT Between 2015 and 2024, outbreaks of muscular and visceral granulomatous disease, resulting in moderate‐to‐severe mortality in farmed groupers, occurred in southern Taiwan. Initially, affected groupers were screened for granuloma‐associated pathogens, including Mycobacterium spp., Nocardia spp., Photobacterium damselae and Edwardsiella spp ...
Shang‐Ting Wu, Chia‐Yu Hsieh
wiley   +1 more source