Results 101 to 110 of about 42,252 (217)
Characterisation of VHH Antibodies Allosteric Mechanism On IL-6
Signal transduction in response to IL-6 requires binding of the cytokine to its receptors at three distinct receptor-binding sites, referred to as site I (contacting the gp80), site 2 (contacting gp130 between domain 2 and domain 3), and site 3 ...
Amaliawati A. Latiffi (17845090)
core +1 more source
VHH repertoires post DNA/VLP priming and gp140 boosts.
, 2014 VHH sequences from immunized llama 1 at both t = 54 and t = 174 were amplified from their respective phagemid libraries by PCR using primers specific to the 5′ and 3′ conserved regions of the VHH and subjected to 454 sequencing.
Rachael Bashford-Rogers (676773) +15 more
core +1 more source
Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains [PDF]
, 2013 SummaryThe epidermal growth factor receptor (EGFR) is implicated in human cancers and is the target of several classes of therapeutic agents, including antibody-based drugs.
van Bergen en Henegouwen, Paul M.P. +4 more
core +1 more source
Characterization of HexDetect and HexBlock VHHs
, 2023 Nuförtiden används antikroppar ofta i terapier och diagnostik. Antikroppar kan förstärka immunsvar och stödja kroppens eget försvar mot patogener och cancer. Klassiska vägar för antikroppar att göra det är antikroppsberoende cellulär cytotoxicitet (ADCC) eller antikroppsberoende cellulär fagocytos (ADCP). En annan naturlig försvarsmekanism
openaire +1 more source
VHH CONSTRUCTS FOR DIVERTING AN IMMUNE RESPONSE
, 2018 The invention relates to a novel VHH construct which can be bound by a complete antibody without the antigen-binding properties of said VHH construct being adversely affected.
FÜNER Jonas +3 more
core
A VHH antibody (or nanobody) is the antigen binding fragment of heavy chain only antibodies. Discovered nearly 25\ua0years ago, they have been investigated for their use in clinical therapeutics and immunodiagnostics, and more recently for environmental ...
core
Development of CLDN18.2-specific VHH CAR T cells for treatment of gastrointestinal cancers
Solid tumors such as gastrointestinal and esophageal cancers continue to confer poor prognosis for patients, and treatment options remain limited. While hematological malignancies have benefitted from advances in targeted immunotherapies like Chimeric ...
Tuinman, Julia
core +4 more sources
Tunable hydrogel-based VHH delivery for intra-articular osteoararthritis therapy
Purpose (the aim of the study): Current osteoarthritis (OA) treatments based on intra-articular injections provide only temporary relief due to fast clearance from the joint.
Larrea, Carolina Serrano +5 more
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, 2015 VHHs or nanobodies are widely acknowledged as interesting diagnostic and therapeutic tools. However, for some applications, multivalent antibody formats, such as the dimeric VHH-Fc format, are desired to increase the functional affinity.
De Rycke, Riet +17 more
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, 2015 a) ELISA with overlapping peptides corresponding to the P domain of VP1 NoV. b) Putative linear epitope of VHH M6 shown in the structure of a GII.4 P dimer.
Andrea Aguilar (782612) +8 more
core +1 more source