Results 111 to 120 of about 42,252 (217)

Anti-HIV activity of germ line V gene VHH.

, 2014
GL VHH comprising inferred germ line V gene paired with the mature VHH CDR3 and J region were produced. GL VHH binding to (A) clade B immunogen R2 gp140 and (B) clade C immunogen 96ZM9651.02 gp140 was assessed by ELISA as per the materials and methods ...
Rachael Bashford-Rogers (676773), Paul Kellam (6413), Vanina Grippo (676776), Luke Granger (676772), Gillian Dekkers (676774), Ian Anderson (151648), Dan Frampton (517265), Ariberto Fassati (151654), Lucy Rutten (386540), Michael S. Seaman (155998), Nika M. Strokappe (386532), Robin A. Weiss (254468), Willie Koh (676775), Laura E. McCoy (386535), Alexander Kliche (639184), Theo Verrips (35621)   +15 more
core   +1 more source

Transdermal Administration of Nanobody Molecules using Hydrogel‐Forming Microarray Patch Technology: A Unique Delivery Approach

Macromolecular Materials and Engineering
Nanobody molecules, derived from heavy‐chain only antibodies in camelids, represent the next generation of biotherapeutics. In addition to low immunogenicity, high stability, and potency, their single‐domain format facilitates the construction of ...
Aaron R. J. Hutton, Melissa Kirkby, Tom Van Bogaert, Peter Casteels, Christelle Nonne, Veronique De Brabandere, Ortwin Van deVyver, Lalit K. Vora, Ismaiel A. Tekko, Helen O. McCarthy, Ryan F. Donnelly   +10 more
doaj   +1 more source

Biparatopic anti-PCSK9 antibody enhances the LDL-uptake in HepG2 cells

Scientific Reports
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target to reduce lipids. In 2020, we reported a chimeric camelid-human heavy chain antibody VHH-B11-Fc targeting PCSK9.
Xinyang Li, Wei Zhang, Yu Shu, Rui Huo, Chengyang Zheng, Qi Qi, Pengfei Fu, Jie Sun, Yuhuan Wang, Yan Wang, Juxu Lu, Xiangjie Zhao, Guoyou Yin, Qingqing Wang, Jun Hong   +14 more
doaj   +1 more source

Mechanisms and applications of camelid variable heavy-chain nanobodies against bacterial and parasitic protozoal pathogens. [PDF]

Front Immunol
Gattan HS, Alandijany TA.
europepmc   +1 more source

Multiobjective V_HH discovery through integrated high-throughput screening and AlphaFold3-guided structural prioritization. [PDF]

Sci Adv
Overath MD, Thumtecho S, Rivera-de-Torre E, Benard-Valle M, Wolff DS, Grahadi R, Björnsson KH, Rygaard ASH, Hofmann N, Ledergerber J, Ljungars A, Laustsen AH, Olsson S, Fryer TJ, Jenkins TP.   +14 more
europepmc   +1 more source

Camelid VHHs as a Versatile Platform for Combating Viral Infections. [PDF]

Pharmaceuticals (Basel)
Mufrrih M, Alandijany TA.
europepmc   +1 more source

Optimization of antibody binding by adjusting thermodynamic stability during the maturation of antibody affinities. [PDF]

Protein Sci
Akazawa-Ogawa Y, Matsuda T, Kiyose N, Miyazaki N, Fukuta T, Adachi M, Ito Y, Hagihara Y.   +7 more
europepmc   +1 more source

AVIDbase: A biologically accurate structural dataset of nanobody-antigen complexes. [PDF]

Protein Sci
Medved T, Lah J, Miličić G, Hadži S.
europepmc   +1 more source

A tool to pulse-label yeast nuclear pore complexes in imaging and biochemical experiments. [PDF]

Elife
Veldsink AC, Fischer JS, Hell S, Weis K, Veenhoff LM.   +4 more
europepmc   +1 more source

Development and Humanization of a Camelid-Derived Neutralizing Nanobody Targeting Botulinum Neurotoxin Type A. [PDF]

Int J Nanomedicine
Jiang Y, Xin W, Lu J, Wang R, Guo J, Du P, Gao C, Yu Y, Yang Z.   +8 more
europepmc   +1 more source