Results 111 to 120 of about 41,395 (219)

Advancing a virtual home hospital: a blueprint for development and expansion

BMJ Open Quality
Background The rising demand for hospitals has spurred increased interest in adopting virtual home hospital (VHH) care models. Development in this area often uses rigid research methods.
Pamela Mathura, Natalie McMurtry, Narmin Kassam, Greg Hrynchyshyn, Isabella Pascheto, Haley Dytoc-Fong   +5 more
doaj   +1 more source

Botulinum Neurotoxins and Botulism: A Novel Therapeutic Approach

Toxins, 2011
Specific treatment is not available for human botulism. Current remedial mainstay is the passive administration of polyclonal antibody to botulinum neurotoxin (BoNT) derived from heterologous species (immunized animal or mouse hybridoma) together with ...
Wanpen Chaicumpa, Jeeraphong Thanongsaksrikul   +1 more
doaj   +1 more source

Characterization of HexDetect and HexBlock VHHs

, 2023
Nuförtiden används antikroppar ofta i terapier och diagnostik. Antikroppar kan förstärka immunsvar och stödja kroppens eget försvar mot patogener och cancer. Klassiska vägar för antikroppar att göra det är antikroppsberoende cellulär cytotoxicitet (ADCC) eller antikroppsberoende cellulär fagocytos (ADCP). En annan naturlig försvarsmekanism
openaire   +1 more source

Inhibition of tau neuronal internalization using anti-tau single domain antibodies

Nature Communications
In Alzheimer’s disease, tau pathology spreads across brain regions as the disease progresses. Intracellular tau can be released and taken up by nearby neurons.
Clément Danis, Elian Dupré, Thomas Bouillet, Marine Denéchaud, Camille Lefebvre, Marine Nguyen, Justine Mortelecque, François-Xavier Cantrelle, Jean-Christophe Rain, Xavier Hanoulle, Morvane Colin, Luc Buée, Isabelle Landrieu   +12 more
doaj   +1 more source

Neutralizing VHH Antibodies Targeting the Spike Protein of PEDV

Veterinary Sciences
Porcine epidemic diarrhea virus (PEDV) is a highly contagious coronavirus that infect pigs’ intestinal epithelial cells, causing high morbidity and mortality. Due to the rapid mutation of PEDV, vaccine efficacy is uncertain, prompting exploration of alternative treatments.
Li Zhang, Wei Miao, Mo Zhou, Miao Lin, Changyao Fu, Zhi Wu, Xinnuo Lei, Jialong Xu, Shinuo Cao, Shanyuan Zhu   +9 more
openaire   +3 more sources

Comparative analysis of CDR3 length-dependent patterns in VHHs

Frontiers in Immunology
IntroductionVHHs, or nanobodies, are distinguished by their compact size, high stability, and unique ability to selectively target specific epitopes. The CDR3 region in VHHs, which plays a crucial role in antigen binding, exhibits significant diversity and varies among species.MethodThis study systematically examined CDR3 length dependent patterns by ...
Zhang, Lu, Yang, Tianyu, Zhang, Yao, Yan, Jiahui, Li, Jiaguo, Xu, Wenfeng, Zhu, Weimin, Wang, Xinhao   +7 more
openaire   +3 more sources

From Llama to Nanobody: A Streamlined Workflow for the Generation of Functionalised VHHs

BIO-PROTOCOL
Nanobodies are recombinant antigen-specific single domain antibodies (VHHs) derived from the heavy chain-only subset of camelid immunoglobulins. Their small molecular size, facile expression, high affinity, and stability have combined to make them unique targeting reagents with numerous applications in the biomedical sciences.
Eyssen, LEA, Ramadurai, S, Abdelkarim, S, Buckle, I, Cornish, K, Lin, H, Jones, AK, Stephens, GJ, Owens, RJ   +8 more
openaire   +4 more sources

Neutralization of the Pandemic Influenza A/H1N1 Virus with Lama glama Humanized Nanobodies (VHH)

Antibodies
Background/Objetives: Nanobodies (VHH) have become an excellent tool for diagnosis, therapy, and research since VHH shows a high capability of recognizing and neutralizing antigens.
Zeila Yazmín Páez-Hernández, Jose Luis Stephano-Hornedo, Jose Alberto Bolaños-Prats, Iván Córdova-Guerrero, Mariana Macías-Alonso, Joaquín G. Marrero, Angel Pulido Capiz, Victor García González   +7 more
doaj   +1 more source

Transdermal Administration of Nanobody Molecules using Hydrogel‐Forming Microarray Patch Technology: A Unique Delivery Approach

Macromolecular Materials and Engineering
Nanobody molecules, derived from heavy‐chain only antibodies in camelids, represent the next generation of biotherapeutics. In addition to low immunogenicity, high stability, and potency, their single‐domain format facilitates the construction of ...
Aaron R. J. Hutton, Melissa Kirkby, Tom Van Bogaert, Peter Casteels, Christelle Nonne, Veronique De Brabandere, Ortwin Van deVyver, Lalit K. Vora, Ismaiel A. Tekko, Helen O. McCarthy, Ryan F. Donnelly   +10 more
doaj   +1 more source

Biparatopic anti-PCSK9 antibody enhances the LDL-uptake in HepG2 cells

Scientific Reports
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target to reduce lipids. In 2020, we reported a chimeric camelid-human heavy chain antibody VHH-B11-Fc targeting PCSK9.
Xinyang Li, Wei Zhang, Yu Shu, Rui Huo, Chengyang Zheng, Qi Qi, Pengfei Fu, Jie Sun, Yuhuan Wang, Yan Wang, Juxu Lu, Xiangjie Zhao, Guoyou Yin, Qingqing Wang, Jun Hong   +14 more
doaj   +1 more source