Results 121 to 130 of about 58,013 (257)

Surface Plasmon Resonance (SPR) Workflow for Comparative Analysis of Nanobody Variants Binding to Lysozyme as a Model Ligand

Current Protocols, Volume 6, Issue 5, May 2026.
Abstract Developing protein interaction–based technologies such as biosensors requires a clear understanding of receptor‐target kinetics. Nanobodies, which are camelid‐derived single‐domain antibodies, are ideal biosensor receptors due to their high specificity, stability, and ease of production. During biosensor development, multiple nanobody variants
Escarlet Díaz‐Galicia, Nicoleta Gutu, Yuli Peng, Almira Valitova, Dominik Renn, Magnus Rueping   +5 more
wiley   +1 more source

Enhancement of Polymeric Immunoglobulin Receptor Transcytosis by Biparatopic VHH

PLoS ONE, 2011
The polymeric immunoglobulin receptor (pIgR) ensures the transport of dimeric immunoglobulin A (dIgA) and pentameric immunoglobulin M (pIgM) across epithelia to the mucosal layer of for example the intestines and the lungs via transcytosis. Per day the human pIgR mediates the excretion of 2 to 5 grams of dIgA into the mucosa of luminal organs.
Chris D Emmerson, Els J van der Vlist, Myrthe R Braam, Peter Vanlandschoot, Pascal Merchiers, Hans J W de Haard, C Theo Verrips, Paul M P van Bergen en Henegouwen, Edward Dolk   +8 more
openaire   +4 more sources

In vivo CAR therapies: Turning the patient into their own CAR factory

HemaSphere, Volume 10, Issue 5, May 2026.
Abstract Over the past decade, ex vivo autologous chimeric antigen receptor (CAR)‐T‐cell therapies have reshaped the treatment of B‐cell malignancies. Despite their remarkable clinical efficacy, their application remains limited by complex manufacturing processes, demanding logistics, long turnaround times, and substantial costs. In vivo CAR approaches
François Vilcot, Carole‐Anne Brugère, Jaime Fuentealba, Roch Houot   +3 more
wiley   +1 more source

Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C.

PLoS ONE, 2012
Many of the neutralising antibodies, isolated to date, display limited activities against the globally most prevalent HIV-1 subtypes A and C. Therefore, those subtypes are considered to be an important target for antibody-based therapy.
Nika Strokappe, Agnieszka Szynol, Marlèn Aasa-Chapman, Andrea Gorlani, Anna Forsman Quigley, David Lutje Hulsik, Lei Chen, Robin Weiss, Hans de Haard, Theo Verrips   +9 more
doaj   +1 more source

Variance estimation for measures of change in probability sampling

, 2003
We propose to estimate the design variance of absolute changes between two cross-sectional estimators under rotating sampling schemes. We show that the variance estimator proposed is generally positive.
Berger, Yves G.
core  

A Syndecan‐Based Genetic Approach to Coat the Surface of Small Extracellular Vesicles With Nanobodies

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Small extracellular vesicles (sEVs) are promising vehicles for targeted therapeutic delivery, but strategies for their surface functionalization remain limited. Here, we present a reliable and simple genetic approach that enables customized modification of sEV surfaces and supports enhanced sEV uptake by recipient cells. This strategy is based
Lukas Hyka, Sofie Meeussen, Rania Ghossoub, Michiel De Coster, Elke De Bruyne, Guido David, Patrick Chames, Pascale Zimmermann   +7 more
wiley   +1 more source

Botulinum Neurotoxins and Botulism: A Novel Therapeutic Approach

Toxins, 2011
Specific treatment is not available for human botulism. Current remedial mainstay is the passive administration of polyclonal antibody to botulinum neurotoxin (BoNT) derived from heterologous species (immunized animal or mouse hybridoma) together with ...
Wanpen Chaicumpa, Jeeraphong Thanongsaksrikul   +1 more
doaj   +1 more source

Advancing a virtual home hospital: a blueprint for development and expansion

BMJ Open Quality
Background The rising demand for hospitals has spurred increased interest in adopting virtual home hospital (VHH) care models. Development in this area often uses rigid research methods.
Pamela Mathura, Natalie McMurtry, Narmin Kassam, Greg Hrynchyshyn, Isabella Pascheto, Haley Dytoc-Fong   +5 more
doaj   +1 more source

The dynamics of public opinion under majority rules

, 2001
This note explains the process of public opinion formation via a locally interactive, space-time analysis. The model we use is a special case of the general framework for modelling social interaction proposed in Blume and Durlauf (2001).
Corradi, V., Ianni, A.
core  

VHH Nanobody Versatility against Pentameric Ligand-Gated Ion Channels

Journal of Medicinal Chemistry
Pentameric ligand-gated ion channels provide rapid chemical-electrical signal transmission between cells in the central and peripheral nervous system. Their dysfunction is associated with many nervous system disorders. They are composed of five identical (homomeric receptors) or homologous (heteromeric receptors) subunits.
Dorota Nemecz, Weronika A. Nowak, Ákos Nemecz   +2 more
openaire   +2 more sources