Results 131 to 140 of about 38,752 (185)

Multifunctional ACE2-nanobody fusion design for pan-specific neutralization and cardiovascular protection in SARS coronavirus infection. [PDF]

Antimicrob Agents Chemother
Sulea T, Stuible M, Moreno M, Pelletier A, Rossotti MA, Cepero-Donates Y, Slinn J, Salois P, Tran A, Hewitt M, Yogi A, Rohani N, Cass B, Lenferink AEG, Tanha J, Ling B, Lessard E, Delafosse L, Sandhu JK, Stanimirovic D.   +19 more
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HSP-1-specific nanobodies alter chaperone function in vitro and in vivo. [PDF]

J Biol Chem
Urban ND, Gharat K, Mattiola ZJ, Scheutzow A, Klaiss A, Tabler S, Huffaker AW, Grootveld M, Skinner ME, Zheng W, O'Meara MJ, Kirstein J, Truttmann MC.   +12 more
europepmc   +1 more source

Enhancing Antigen Recognition of Living Cells by Site-Specific VHH Antibody Conjugation. [PDF]

Chembiochem
Zhu C, Ichikawa Y, Yamashita F, Higuchi Y.   +3 more
europepmc   +1 more source

Identification of allo- or orthosteric VHH/single-domain antibodies that enhance or block pathogen binding to Siglec-1 on dendritic cells

Brink H, Affandi A, Man S, Dekker N, Große Wichtrup E, Bouma R, Seyed Toutounchi N, Konijn V, Stolwijk J, van Hamme J, Olesek K, Heijnen D, Fish A, Moutsiopoulou A, Celie P, Dekkers G, Heukers R, Mastrobattista E, Smit M, van Kooyk Y, Heikema A, Kootstra N, Geijtenbeek T, den Haan J.   +23 more
europepmc   +1 more source

Applications of VHH in cancer diagnosis and therapy

openaire   +2 more sources

Structural Plausibility Without Binding Specificity: Limits of AI-Based Antibody-Antigen Structure Prediction Confidence Scores

Smorodina E, Ali M, Kropivšek Brumat K, Salicari L, Miklavc S, Kappassov A, Fu C, Sormanni P, de Marco A, Greiff V.   +9 more
europepmc   +1 more source

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Expression of VHHs in Saccharomyces cerevisiae

2012
The production of VHHs in microorganisms is relatively straightforward, however the amount of VHH produced per volume unit can vary substantially from hardly detectable to hundreds of milligrams per liter. Expression in Escherichia coli is more commonly used at initial research phase, since production of VHHs for large-scale application in E.
Andrea, Gorlani, Hans, de Haard, Theo, Verrips   +2 more
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Selection of VHHs Under Application Conditions

2012
The successful application of antibody fragments such as VHHs in diagnostic assays, affinity purification, imaging, or therapy is not determined by the specificity and affinity of the antibody fragment alone. The ability to bind the target protein in the environment in which the antibody fragment is intended to functionally perform determines to a ...
Dolk, E., Verrips, C.T., de Haard, J.J.W.   +2 more
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Structure and Function of Camelid VHH

2016
The humoral immune response of camels and llama’s is unique in containing two types of IgG antibodies: classical heterotetrameric and homodimeric heavy chain-only antibodies (HCAbs). Remarkably, these heavy chain antibodies are functional in antigen binding and reach high titers and affinities after immunizing a camelid. Antigen recognition by HCAbs is
Vincke, Cecile, Muyldermans, Serge
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Production of Designer VHH-Based Antibodies in Plants

2022
Simplified monoclonal antibodies can be produced by fusing a VHH or nanobody, derived from camelid heavy-chain-only antibodies to the Fc domain of either IgG (VHH-IgG), IgA (VHH-IgA), or IgY (VHH-IgY). These recombinant antibodies are encoded by a single gene and their production can be easily scaled up in plants.
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