Results 91 to 100 of about 42,252 (217)

Outbreaks of Granulomatous Disease Associated With Vibrio harveyi Infection in Grouper (Epinephelus fuscoguttatus × E. lanceolatus) Aquaculture in Taiwan

Journal of Fish Diseases, Volume 49, Issue 11, November 2026.
ABSTRACT Between 2015 and 2024, outbreaks of muscular and visceral granulomatous disease, resulting in moderate‐to‐severe mortality in farmed groupers, occurred in southern Taiwan. Initially, affected groupers were screened for granuloma‐associated pathogens, including Mycobacterium spp., Nocardia spp., Photobacterium damselae and Edwardsiella spp ...
Shang‐Ting Wu, Chia‐Yu Hsieh
wiley   +1 more source

Neutralization and fetuin competition of H5N1-specific VHH.

, 2013
Monovalent VHH neutralizing Influenza H5N1, A/Vietnam/1203/04 in a pseudotyped neutralization assay. Neutralization (geometric mean of duplicates) is expressed in percentage compared to the virus only and plotted against the concentrations of VHH in ...
Steven Van Gucht (353869), Joris Schillemans (353867), Michael Saunders (353868), Mireille Koenders (353862), Lorena Itatí Ibañez (353866), Xavier Saelens (28372), Nigel J. Temperton (353859), Peter Vanlandschoot (200963), C. Theo Verrips (200972), Bert Schepens (9498), Valérie Rosseels (353860), Robin A. Weiss (254468), Anna Hultberg (35618), Hans J. de Haard (353870), José A. Melero (3110754), Maria Gonzalez-Pajuelo (353864)   +15 more
core   +1 more source

Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C.

PLoS ONE, 2012
Many of the neutralising antibodies, isolated to date, display limited activities against the globally most prevalent HIV-1 subtypes A and C. Therefore, those subtypes are considered to be an important target for antibody-based therapy.
Nika Strokappe, Agnieszka Szynol, Marlèn Aasa-Chapman, Andrea Gorlani, Anna Forsman Quigley, David Lutje Hulsik, Lei Chen, Robin Weiss, Hans de Haard, Theo Verrips   +9 more
doaj   +1 more source

Target-selective cytosolic delivery of cargo proteins using the VHH-presented OLE-ZIP capsules [PDF]

In the pursuit of a new generation of protein pharmaceuticals, the efficient delivery of these therapeutics into cells stands out as a crucial challenge.
Mitsuo, Umetsu, Isamu, Akiba, Kousuke, Takahashi, Naoki, Umezawa, Yasumichi, Inoue, Toshihisa, Mizuno, Shigeaki, Hida   +6 more
core   +1 more source

Advancing a virtual home hospital: a blueprint for development and expansion

BMJ Open Quality
Background The rising demand for hospitals has spurred increased interest in adopting virtual home hospital (VHH) care models. Development in this area often uses rigid research methods.
Pamela Mathura, Natalie McMurtry, Narmin Kassam, Greg Hrynchyshyn, Isabella Pascheto, Haley Dytoc-Fong   +5 more
doaj   +1 more source

Cloning and Expression of Nano Body Gene against Enterotoxin B of Staphylococcus Aureus [PDF]

Journal of Advanced Biomedical Sciences, 2016
Background & Objectives: Staphylococcus aureus bacteria causes many different diseases by secretion of various enterotoxins. Therefore, it is necessary to develop ways that facilitate the detection of enterotoxins.
Zahra Tavassoli, Hamideh Rouhani Nejad, Jalil Fallah Mehrabadi   +2 more
doaj  

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, Volume 13, Issue 55, 5 October 2026.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

CLDN18.2 in pancreatic ductal adenocarcinoma: Biomarker assessment, spatial heterogeneity and therapeutic modality selection

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review presents a framework for selecting Claudin 18.2 (CLDN18.2)‐directed treatment modalities in pancreatic ductal adenocarcinoma according to tumour antigen coverage and spatial distribution. Representative assessment at baseline and reassessment after progression can guide treatment adaptation over time.
Ruyu Tan, Zhexin Zhang, Jiaxin Wang, Roland Andersson, Daniel Ansari, Jinfei Chen   +5 more
wiley   +1 more source

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta, Ramakrishna Vadde, Ganji Purnachandra Nagaraju   +2 more
wiley   +1 more source

Développement et caractérisation de VHH anti-transferrine

, 2017
La transferrine (Tf) est une protéine soluble, responsable de l’approvisionnement des cellules en fer par endocytose du complexe Tf - récepteur de la Tf (RTf). Dans certains cancers, le RTf est surexprimé.
Deyme, Laure
core