Results 91 to 100 of about 41,395 (219)

Cloning and Expression of Nano Body Gene against Enterotoxin B of Staphylococcus Aureus [PDF]

Journal of Advanced Biomedical Sciences, 2016
Background & Objectives: Staphylococcus aureus bacteria causes many different diseases by secretion of various enterotoxins. Therefore, it is necessary to develop ways that facilitate the detection of enterotoxins.
Zahra Tavassoli, Hamideh Rouhani Nejad, Jalil Fallah Mehrabadi   +2 more
doaj  

Anti-VP6 VHH: An Experimental Treatment for Rotavirus A-Associated Disease. [PDF]

PLoS ONE, 2016
Species A Rotaviruses (RVA) remain a leading cause of mortality in children under 5 years of age. Current treatment options are limited. We assessed the efficacy of two VP6-specific llama-derived heavy chain antibody fragments (VHH) -2KD1 and 3B2- as an ...
Lucía Maffey, Celina G Vega, Samuel Miño, Lorena Garaicoechea, Viviana Parreño   +4 more
doaj   +1 more source

Steady‐State and Dynamic Behavior of Geometry‐Tunable Microfluidic Passive Flow Regulators

Small, EarlyView.
Passive microfluidic flow regulators exhibit geometry‐dependent dynamic behavior, where channel width governs the resistance–compliance interactions within the system. Narrow channels produce faster responses with higher bandwidth, while wider channels yield slower responses and stronger attenuation.
Huy Hoang Vu, Tran Vy Khanh Vo, Hafiz Muhammad Musharaf, Haotian Cha, Nam‐Trung Nguyen   +4 more
wiley   +1 more source

A VHH single-domain platform enabling discovery and development of monospecific antibodies and modular neutralizing bispecifics against SARS-CoV-2 variants

Antibody Therapeutics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve, escape coronavirus disease 2019 therapeutics and vaccines, and jeopardize public health.
Marisa L Yang, Tom Z. Yuan, Kara Y Chan, Lin Ding, Zhen Han, Hector Franco, Carson Holliday, Shruthi Kannan, E. Davidson, B. Doranz, K. Chandran, E. Miller, Jessica A. Plante, Scott C Weaver, Eunice Cho, Shweta Kailasan, L. Marsalek, Hoa Giang, Y. Abdiche, Aaron K Sato   +19 more
semanticscholar   +1 more source

Development of a Humanized VHH Based Recombinant Antibody Targeting Claudin 18.2 Positive Cancers

Frontiers in Immunology, 2022
Claudin 18.2 (CLDN18.2), a tight junction (TJ) family protein controlling molecule exchange between cells, is frequently over-expressed in gastric cancer, pancreatic adenocarcinomas and in a fraction of non–small cell lung cancer cases.
W. Zhong, Yimin Lu, Zhe Ma, Yinjun He, Yongfeng Ding, Gaofeng Yao, Zhenxing Zhou, Jiali Dong, Yongliang Fang, Wei-wei Jiang, Weilin Wang, Yanshan Huang   +11 more
semanticscholar   +1 more source

A Versatile Multiplexed Immunofluorescence Strategy for Efficient, Host‐Independent, and Scalable Spatial Protein Profiling

Small Methods, EarlyView.
Crowding‐enhanced multiplex immunofluorescence (umIF) provides a versatile strategy for scalable spatial profiling in FFPE tissues. By improving labeling efficiency across direct, one‐step, and two‐step IF formats, umIF enables host‐species‐independent use of primary antibodies and antibody–nanobody complexes, detection of weak targets, and multicycle ...
Phuong Nguyen, Hongqiang Ma, Dimitrios S. Gotsis, Maomao Chen, Chaojie Zhang, Tushar Talukder Showrav, Marc Schwartz, Brenda Diergaarde, Robert E. Schoen, Rhonda M. Brand, Hua Zhang, Yang Liu   +11 more
wiley   +1 more source

Recent Advances in Photocatalyst‐Driven Protein Labeling and Proximity Mapping

The Chemical Record, EarlyView.
Photocatalyst‐driven protein labeling and proximity mapping have rapidly advanced as powerful strategies for spatiotemporal control in complex biological environments. This review integrates recent developments across single‐electron transfer and energy transfer‐based mechanisms and highlights how catalyst design, reactive intermediates, and diffusion ...
Shinichi Sato, Kazuki Miura, Juki Nakao, Hiroyuki Nakamura   +3 more
wiley   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source