Results 11 to 20 of about 38,752 (185)
Construction of a Humanized Artificial VHH Library Reproducing Structural Features of Camelid VHHs for Therapeutics [PDF]
Antibodies, 2022 A variable domain of heavy chain antibody (VHH) has different binding properties than conventional antibodies. Conventional antibodies prefer binding to the convex portion of the antigen, whereas VHHs prefer epitopes, such as crevices and clefts on the antigen.
Taihei Murakami +9 more
openaire +3 more sources
PLoS ONE, 2022 The blood-brain barrier (BBB) presents a major obstacle in developing specific diagnostic imaging agents for many neurological disorders. In this study we aimed to generate single domain anti-mouse transferrin receptor antibodies (anti-mTfR VHHs) to ...
Shiran Su +2 more
doaj +2 more sources
Development of Antibody-Fragment–Producing Rice for Neutralization of Human Norovirus
Frontiers in Plant Science, 2021 Human norovirus is the leading cause of acute nonbacterial gastroenteritis in people of all ages worldwide. Currently, no licensed norovirus vaccine, pharmaceutical drug, or therapy is available for the control of norovirus infection.
Ai Sasou +23 more
doaj +1 more source
The Dynamics of Vowel Hypo- and Hyperarticulation in Swedish Infant-Directed Speech to 12-Month-Olds
Frontiers in Communication, 2020 Vowel hypo- and hyperarticulation (VHH) was investigated in Swedish infant-directed speech (IDS) to Swedish 12-month-olds using a measure that normalizes across speakers and vowels: the vhh-index. The vhh-index gives the degree of VHH for each individual
Ellen Marklund, Lisa Gustavsson
doaj +1 more source
Scientific Reports, 2022 PCSK9 is an effective target for lowering LDL-c. Previously, a camelid-human chimeric heavy chain antibody VHH-B11-Fc targeting human PCSK9 was designed. It had a potent hypolipidemic effect.
Xinyang Li +4 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Diabetic nephropathy the main reason for end stage renal disease is a common microvascular complication in patients with type 1 and type 2 diabetes. The interleukin-6 (IL-6), acting as a pleiotropic cytokine, play key roles in main autoimmune disorders ...
Nanwen Zhang +12 more
doaj +1 more source
Peptide Linker Affecting the Activity Retention Rate of VHH in Immunosorbents
Biomolecules, 2020 VHH-based immunosorbents are an emerging and promising tool for the removal of toxic substances from plasma. However, the small size of VHHs is a double-edged sword, bringing both benefits and drawbacks to the immunosorbent.
Da Li +5 more
doaj +1 more source
Llama nanoantibodies with therapeutic potential against human norovirus diarrhea. [PDF]
PLoS ONE, 2015 Noroviruses are a major cause of acute gastroenteritis, but no vaccines or therapeutic drugs are available. Llama-derived single chain antibody fragments (also called VHH) are small, recombinant monoclonal antibodies of 15 kDa with several advantages ...
Lorena Garaicoechea +8 more
doaj +1 more source
Biotechnology & Biotechnological Equipment, 2021 Antibodies are key elements in routine immunological tests, having a long history in detection of plant pathogens due to their specificity, reliability and fast performance.
Faith Njeri Njeru, Paul Mbogo Kusolwa
doaj +1 more source
VHH production at the high-luminosity LHC [PDF]
The European Physical Journal Plus, 2019 14 pages, 8 figures, 4 ...
Karl Nordström, Andreas Papaefstathiou
openaire +4 more sources