Construction of a Humanized Artificial VHH Library Reproducing Structural Features of Camelid VHHs for Therapeutics [PDF]
Antibodies, 2022 A variable domain of heavy chain antibody (VHH) has different binding properties than conventional antibodies. Conventional antibodies prefer binding to the convex portion of the antigen, whereas VHHs prefer epitopes, such as crevices and clefts on the ...
Taihei Murakami +9 more
semanticscholar +4 more sources
International Journal of Molecular SciencesCAR-T cell therapy is at the forefront of next-generation multiple myeloma (MM) management, with two B-cell maturation antigen (BCMA)-targeted products recently approved.
Heleen Hanssens +7 more
semanticscholar +4 more sources
From discovery to the clinic: structural insights, engineering options, clinical, and ‘next wave’ applications of camelid-derived single-domain antibodies [PDF]
mAbsCamelid-derived single domain antibodies (sdAbs), referred to as VHHs (variable domains of the heavy chain of a heavy chain-only antibodies), recently emerged as promising building blocks for the construction of therapeutic molecules. As of October 2025,
Andreas Evers +3 more
doaj +2 more sources
Molecular docking study and mapping the binding site of some antiviral nanobodies against receptor binding domain (RBD) of SARS-COV 2 [PDF]
Nanochemistry Research, 2021 Neutralization ability of some antiviral nanobodies was computed against the receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2).
zahra pahlavan, Mohammad Hossein Fatemi
doaj +1 more source
VHH characterization.Recombinant VHHs: Production, characterization and affinity [PDF]
Analytical Biochemistry, 2020 Among the biological approaches to therapeutics, are the cells, such as CAR-T cells engineered or not, the antibodies armed or not, and the smaller protein scaffolds that can be modified to render them specific of other proteins, à la façon of antibodies.
Chabrol, Eric +8 more
openaire +3 more sources
PLoS ONE, 2022 The blood-brain barrier (BBB) presents a major obstacle in developing specific diagnostic imaging agents for many neurological disorders. In this study we aimed to generate single domain anti-mouse transferrin receptor antibodies (anti-mTfR VHHs) to ...
Shiran Su +2 more
doaj +2 more sources
AVIDa-hIL6: A Large-Scale VHH Dataset Produced from an Immunized Alpaca for Predicting Antigen-Antibody Interactions [PDF]
Neural Information Processing Systems, 2023 Antibodies have become an important class of therapeutic agents to treat human diseases. To accelerate therapeutic antibody discovery, computational methods, especially machine learning, have attracted considerable interest for predicting specific ...
Hirofumi Tsuruta +10 more
semanticscholar +1 more source
Development of Antibody-Fragment–Producing Rice for Neutralization of Human Norovirus
Frontiers in Plant Science, 2021 Human norovirus is the leading cause of acute nonbacterial gastroenteritis in people of all ages worldwide. Currently, no licensed norovirus vaccine, pharmaceutical drug, or therapy is available for the control of norovirus infection.
Ai Sasou +23 more
doaj +1 more source
The Dynamics of Vowel Hypo- and Hyperarticulation in Swedish Infant-Directed Speech to 12-Month-Olds
Frontiers in Communication, 2020 Vowel hypo- and hyperarticulation (VHH) was investigated in Swedish infant-directed speech (IDS) to Swedish 12-month-olds using a measure that normalizes across speakers and vowels: the vhh-index. The vhh-index gives the degree of VHH for each individual
Ellen Marklund, Lisa Gustavsson
doaj +1 more source
Scientific Reports, 2022 PCSK9 is an effective target for lowering LDL-c. Previously, a camelid-human chimeric heavy chain antibody VHH-B11-Fc targeting human PCSK9 was designed. It had a potent hypolipidemic effect.
Xinyang Li +4 more
doaj +1 more source