Molecular recognition requires dimerization of a VHH antibody
mAbs, 2023 Camelid heavy-chain-only antibodies are a unique class of antibody that possesses only a single variable domain (termed VHH) for antigen recognition.
Christopher A. Smith +7 more
doaj +4 more sources
VHH Antibodies: Reagents for Mycotoxin Detection in Food Products
Sensors, 2018 Mycotoxins are the toxic secondary metabolites produced by fungi and they are a worldwide public health concern. A VHH antibody (or nanobody) is the smallest antigen binding entity and is produced by heavy chain only antibodies.
Jia Wang, Xiaohong Wang
exaly +4 more sources
Antibodies, 2019 Broad and potent neutralizing llama single domain antibodies (VHH) against HIV-1 targeting the CD4 binding site (CD4bs) have previously been isolated upon llama immunization.
Winfried Weissenhorn +2 more
exaly +4 more sources
Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules. [PDF]
PLoS ONE, 2011 For efficient prevention of viral infections and cross protection, simultaneous targeting of multiple viral epitopes is a powerful strategy. Llama heavy chain antibody fragments (VHH) against the trimeric envelope proteins of Respiratory Syncytial Virus (
Anna Hultberg +15 more
doaj +2 more sources
Peptide Linker Affecting the Activity Retention Rate of VHH in Immunosorbents
Biomolecules, 2020 VHH-based immunosorbents are an emerging and promising tool for the removal of toxic substances from plasma. However, the small size of VHHs is a double-edged sword, bringing both benefits and drawbacks to the immunosorbent.
Da Li +5 more
doaj +2 more sources
Bispecific single-domain antibody (VHH) fused with human IgG1 Fc with dual specificity effectively neutralize Naja Kaouthia venom. [PDF]
PLoS Neglected Tropical DiseasesNaja kaouthia, or the monocled cobra, is one of the most medically important snakes in Thailand, responsible for approximately 17% of snakebite cases. Conventional horse-derived antivenoms are lifesaving, yet they may trigger severe allergic reactions ...
Kanokporn Pothisamutyothin +4 more
doaj +2 more sources
Molecular docking study and mapping the binding site of some antiviral nanobodies against receptor binding domain (RBD) of SARS-COV 2 [PDF]
Nanochemistry Research, 2021 Neutralization ability of some antiviral nanobodies was computed against the receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2).
zahra pahlavan, Mohammad Hossein Fatemi
doaj +1 more source
VHH characterization.Recombinant VHHs: Production, characterization and affinity [PDF]
Analytical Biochemistry, 2020 Among the biological approaches to therapeutics, are the cells, such as CAR-T cells engineered or not, the antibodies armed or not, and the smaller protein scaffolds that can be modified to render them specific of other proteins, à la façon of antibodies.
Chabrol, Eric +8 more
openaire +3 more sources
Llama VHH as immunotherapeutics in Alzheimer's disease [PDF]
, 2013 Alzheimer's Disease (AD) is the most common form of dementia among elderly in the Western world. AD is a devastating neurodegenerative disease where patients starting with episodic memory problems end up completely bedridden and care dependent. At present there is no real therapy stopping or reversing AD progression.
Sub Biomolecular Imaging +2 more
openaire +4 more sources