Results 21 to 30 of about 136,940 (248)
Novel Platforms for the Development of a Universal Influenza Vaccine
Frontiers in Immunology, 2018 Despite advancements in immunotherapeutic approaches, influenza continues to cause severe illness, particularly among immunocompromised individuals, young children, and elderly adults.
Arun Kumar +5 more
doaj +1 more source
Science, 2017 Influenza The morbidity and economic tolls of influenza virus are huge, regardless of its capacity to kill. Vaccines and therapies to control this persistent threat are limited. In structural studies, Kadam and Wilson show how the broad-spectrum antiviral arbidol inactivates viral hemagglutinin (HA).
openaire +2 more sources
An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism. [PDF]
, 2016 Influenza viruses cause seasonal flu each year and pandemics or epidemic sporadically, posing a major threat to public health. Recently, a new influenza D virus (IDV) was isolated from pigs and cattle. Here, we reveal that the IDV utilizes 9-O-acetylated
Chen, Xi +8 more
core +3 more sources
Microbiology Indonesia, 2012 Nine HA genes of influenza A (H1N1) viruses originating from swine which were detected in 2009 in Jakarta, Indonesia, were characterized in this study. Nasopharyngeal and/or pharyngeal samples were extracted to obtain viral RNA genomes.
ANDI YASMON +5 more
doaj +1 more source
Neutralizing Antibodies Targeting the Conserved Stem Region of Influenza Hemagglutinin
Vaccines, 2020 Influenza continues to be a public health threat despite the availability of annual vaccines. While vaccines are generally effective at inducing strain-specific immunity, they are sub-optimal or ineffective when drifted or novel pandemic strains arise ...
Sabari Nath Neerukonda +2 more
doaj +1 more source
Journal of Infection in Developing Countries, 2015 Introduction: Saudi Arabia (SA) experienced a highly pathogenic avian influenza (HPAI) H5N1 outbreak in domesticated birds in 2007. Methodology: Forty-three hemagglutinin (HA) and 41 neuraminidase (NA) genes of HPAI H5N1 viruses were sequenced and ...
Ahmed Ali Al-Qahtani +10 more
doaj +1 more source
γδ T Cells Provide Protective Function in Highly Pathogenic Avian H5N1 Influenza A Virus Infection
Frontiers in Immunology, 2018 Given the high mortality rate (>50%) and potential danger of intrapersonal transmission, highly pathogenic avian influenza (HPAI) H5N1 epidemics still pose a significant threat to humans.
Peng Dong +11 more
doaj +1 more source
Pharmaceutics, 2021 Sialic acid that presents on the surface of lung epithelial cells is considered as one of the main binding targets for many respiratory viruses, including influenza and the current coronavirus (SARS-CoV-2) through the viral surface protein hemagglutinin.
Haya A. Alfassam +13 more
doaj +1 more source
Mitogenicity of influenza hemagglutinin glycoproteins and influenza viruses bearing H2-hemagglutinin [PDF]
Infection and Immunity, 1981 The hemagglutinin glycoprotein is responsible for the mitogenic effect of influenza A viruses of the H2N2 subtype. This was indicated by the ability of viruses bearing the H2-hemagglutinin glycoprotein, regardless of its associated neuraminidase, to induce lymphocyte proliferation in normal spleen cell suspensions and by the ability of antisera with ...
R B, Armstrong +4 more
openaire +2 more sources
Substitutions near the hemagglutinin receptor-binding site determine the antigenic evolution of influenza A H3N2 viruses in U.S. swine [PDF]
, 2014 Swine influenza A virus is an endemic and economically important pathogen in pigs, with the potential to infect other host species. The hemagglutinin (HA) protein is the primary target of protective immune responses and the major component in swine ...
A. L. Vincent +58 more
core +2 more sources