Results 21 to 30 of about 102,208 (283)

Intranasal immunization with a recombinant protein based on the M2e peptide and second subunit of influenza A viral hemagglutinin fragment induces a cross-protective humoral and Tcell response in mice

Медицинская иммунология, 2020
Development of vaccines with a broad-spectrum of protection is one of the priorities in the programs of influenza prevention. Recently, the conserved fragments of influenza virus proteins (M1, M2, NP, the second subunit of the hemagglutinin HA2) provoke ...
M. A Shuklina, L. A Stepanova, A. A. Kovaleva, A. V. Korotkov, A. A. Shaldzhyan, M. V. Zaitceva, E. I. Eletskaya, L. M. Tsybalova   +7 more
doaj   +1 more source

Stalking influenza by vaccination with pre-fusion headless HA mini-stem. [PDF]

, 2016
Inaccuracies in prediction of circulating viral strain genotypes and the possibility of novel reassortants causing a pandemic outbreak necessitate the development of an anti-influenza vaccine with increased breadth of protection and potential for rapid ...
Carnell, George, Temperton, Nigel J., Mallajosyula, VVA, Poon, Leo LM, Mallajosyula, V Vamsee Aditya, Temperton, N, Poon, LLM, Chin, Alex WH, Mallajosyula, VV, Chin, Alex W H, Carnell, G, Valkenburg, Sophie A, Li, OTW, Poon, Leo L M, Chin, WH, Mallajosyula, Vamsee Aditya V, Poon, LML, Li, Olive T W, Varadarajan, Raghavan, Doak, SA, Li, Olive TW, Temperton, Nigel, Chin, AWH, Valkenburg, SA, Varadarajan, R   +24 more
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Influenza monitoring in Sardinia, Italy identifies H3 subtype in Mediterranean wild migratory birds

Journal of Infection in Developing Countries, 2012
Introduction: Wild migratory birds are global distributors of pathogens. Sardinia, Italy, is the second largest Island in the Mediterranean and is a land bridge between Europe and Africa.
Alyson Ann Kelvin, Dionigia Meloni, Paola Sansonetti, Ilaria Borghetto, Thomas Rowe, Rosaria Santangelo, Danilo Pisu, Cheryl M. Cameron, Bianca Paglietti, David Banner, Amber Farooqui, Patrizia Marongiu, Antonella Santona, Giovanni Fadda, David J. Kelvin, Salvatore Rubino   +15 more
doaj   +1 more source

Gluing up hemagglutinin [PDF]

Science, 2017
Influenza The morbidity and economic tolls of influenza virus are huge, regardless of its capacity to kill. Vaccines and therapies to control this persistent threat are limited. In structural studies, Kadam and Wilson show how the broad-spectrum antiviral arbidol inactivates viral hemagglutinin (HA).
openaire   +2 more sources

A single residue substitution in the receptor-binding domain of H5N1 hemagglutinin is critical for packaging into pseudotyped lentiviral particles [PDF]

, 2012
© 2012 Tang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
Shui-Ling Chu, Béatrice Nal, Tang, D, Chi-Hong Lam, Yuen-Man Lam, Tang Dong-Jiang, Lam Chi-Hong, Lam Yuen-Man, Bruzzone Roberto, Peiris, JS, Buchy Philippe, Siu, YL, Dong-Jiang Tang, Chu Shui-Ling, Tang, DJ, Yu-Lam Siu, Nal, B, Peiris J. S. Malik, J S Malik Peiris, Peiris, J S Malik, Siu Yu-Lam, Bruzzone, R, Chu, SL, Lam, CH, Philippe Buchy, Buchy, Philippe, Tang, Dong-Jiang, Bruzzone, Roberto, Nal Béatrice, Lam, YM, Chu, Shui-Ling, Siu, Yu-Lam, Lam, Chi-Hong, Roberto Bruzzone, Peiris, JSM, Nai, B, Buchy, P, Nal, Béatrice, Lam, Yuen-Man   +38 more
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Antigenic drift in H5N1 avian influenza virus in poultry is driven by mutations in major antigenic sites of the hemagglutinin molecule analogous to those for human influenza virus [PDF]

, 2011
H5N1 highly pathogenic avian influenza virus has been endemic in poultry in Egypt since 2008, notwithstanding the implementation of mass vaccination and culling of infected birds.
Arafa, Abdel, Temperton, Nigel J., Giovanni Cattoli, Alessandra Buratin, Mona Meherez Aly, Adelaide Milani, Cattoli, Giovanni, Milani, Adelaide, Zecchin, Bianca, Ilaria Capua, Capua, Ilaria, Eleonora Molesti, Bianca Zecchin, Abdel Arafa, Buratin, Alessandra, Aly, Mona Meherez, Temperton, Nigel, Meherez Aly, Mona, Nigel Temperton, Molesti, Eleonora   +19 more
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Spatiotemporal Associations and Molecular Evolution of Highly Pathogenic Avian Influenza A H7N9 Virus in China from 2017 to 2021

Viruses, 2021
Highly pathogenic (HP) H7N9 avian influenza virus (AIV) emerged in China in 2016. HP H7N9 AIV caused at least 33 human infections and has been circulating in poultry farms continuously since wave 5.
Dongchang He, Min Gu, Xiyue Wang, Xiaoquan Wang, Gairu Li, Yayao Yan, Jinyuan Gu, Tiansong Zhan, Huiguang Wu, Xiaoli Hao, Guoqing Wang, Jiao Hu, Shunlin Hu, Xiaowen Liu, Shuo Su, Chan Ding, Xiufan Liu   +16 more
doaj   +1 more source

Recognition of viral glycoproteins by influenza A-specific cross- reactive cytolytic T lymphocytes [PDF]

, 1980
Two populations of cytolytic T lymphocytes (CTL) generated after influenza A virus infection can be distinguished into one with specificity for the sensitizing hemagglutinin type and a second with cross-reactivity for antigens induced by other type-A ...
Klenk, H, Gething, M. J., Koszinowski, Ulrich H., Gething, MJ, Waterfield, MD, M D Waterfield, U H Koszinowski, M J Gething, Koszinowski, UH, Klenk, H. D., H Allen, Allen, H, Gething, M, Koszinowski, U H, H D Klenk, Allen, H., Waterfield, M. D., Klenk, HD   +17 more
core   +1 more source

Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies

Vaccines, 2020
The stalk domain of the hemagglutinin has been identified as a target for induction of protective antibody responses due to its high degree of conservation among numerous influenza subtypes and strains.
Juan Manuel Carreño, Jacqueline U. McDonald, Tara Hurst, Peter Rigsby, Eleanor Atkinson, Lethia Charles, Raffael Nachbagauer, Mohammad Amin Behzadi, Shirin Strohmeier, Lynda Coughlan, Teresa Aydillo, Boerries Brandenburg, Adolfo García-Sastre, Krisztian Kaszas, Min Z. Levine, Alessandro Manenti, Adrian B. McDermott, Emanuele Montomoli, Leacky Muchene, Sandeep R. Narpala, Ranawaka A. P. M. Perera, Nadine C. Salisch, Sophie A. Valkenburg, Fan Zhou, Othmar G. Engelhardt, Florian Krammer   +25 more
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Expanding Mouse-Adapted Yamagata-like Influenza B Viruses in Eggs Enhances In Vivo Lethality in BALB/c Mice

Viruses, 2022
Despite the yearly global impact of influenza B viruses (IBVs), limited host range has been a hurdle to developing a readily accessible small animal disease model for vaccine studies.
Matthew J. Pekarek, Erika M. Petro-Turnquist, Adam Rubrum, Richard J. Webby, Eric A. Weaver   +4 more
doaj   +1 more source