Results 41 to 50 of about 108,411 (200)

R-DOTAP Cationic Lipid Nanoparticles Outperform Squalene-Based Adjuvant Systems in Elicitation of CD4 T Cells after Recombinant Influenza Hemagglutinin Vaccination

Viruses, 2023
It is clear that new approaches are needed to promote broadly protective immunity to viral pathogens, particularly those that are prone to mutation and escape from antibody-mediated immunity. Prototypic pathogens of this type are influenza and SARS-CoV-2,
Thomas R. Henson, Katherine A. Richards, Siva K. Gandhapudi, Jerold G. Woodward, Andrea J. Sant   +4 more
doaj   +1 more source

hemagglutinin trees NA/OT xml

, 2014
hemagglutinin trees NA/OT ...
Trevor Bedford (376961), Robert J. Woods (175743), Mercedes Pascual (19597), Edward B. Baskerville (189872), Zinder, Daniel, Baskerville, Edward B., Woods, Robert J., Roy, Manojit, Manojit Roy (104218), Bedford, Trevor, Pascual, Mercedes, Daniel Zinder (106377)   +11 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Chemoenzymatic Synthesis of 6‐Sulfo Sialyl Lewisx Containing Glycans to Probe the Receptor Specificity of MERS Coronavirus

Angewandte Chemie, EarlyView.
A chemoenzymatic methodology is described that provided a panel of 6‐sulfo sialyl Lewisx‐containing glycans that were probed for receptor specificity of MERS‐CoV. Although the fucoside of 6‐sulfo‐SLex does not directly interact with the spike, it pre‐organizes the molecule into a conformation to allow a salt bridge between the sulfate and the ...
Yunfei Wu, Anne L.M. Kimpel, Jacobus P. van Trijp, Elif Uslu, Gaёl M. Vos, Luca Unione, Robert P. de Vries, Geert‐Jan Boons   +7 more
wiley   +2 more sources

Structural Consequences of Antigenic Variants of Human A/H3N2 Influenza Viruses

Viruses, 2023
The genetic basis of antigenic drift of human A/H3N2 influenza virus is crucial to understanding the constraints of influenza evolution and determinants of vaccine escape.
David Francis Burke
doaj   +1 more source

hemagglutinin trees global

, 2014
Hemagglutinin trees generated by BEAST for global analysis in NEXUS ...
Trevor Bedford (376961), Robert J. Woods (175743), Mercedes Pascual (19597), Edward B. Baskerville (189872), Zinder, Daniel, Baskerville, Edward B., Woods, Robert J., Roy, Manojit, Manojit Roy (104218), Bedford, Trevor, Pascual, Mercedes, Daniel Zinder (106377)   +11 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

A Multi-Hemagglutinin-Based Enzyme-Linked Immunosorbent Assay to Serologically Detect Influenza A Virus Infection in Animals

Veterinary Sciences, 2019
Mammals can play a role as an intermediate host in the emergence of mammalian-adapted reassortants or mutants of avian influenza A viruses, with pandemic potential.
Miki Okumura, Akiko Takenaka-Uema, Shin Murakami, Taisuke Horimoto   +3 more
doaj   +1 more source

Structural Requirements in the Hemagglutinin Cleavage Site-Coding RNA Region for the Generation of Highly Pathogenic Avian Influenza Virus

Pathogens, 2021
Highly pathogenic avian influenza viruses (HPAIVs) with H5 and H7 hemagglutinin (HA) subtypes are derived from their low pathogenic counterparts following the acquisition of multiple basic amino acids in their HA cleavage site. It has been suggested that
Yurie Kida, Kosuke Okuya, Takeshi Saito, Junya Yamagishi, Aiko Ohnuma, Takanari Hattori, Hiroko Miyamoto, Rashid Manzoor, Reiko Yoshida, Naganori Nao, Masahiro Kajihara, Tokiko Watanabe, Ayato Takada   +12 more
doaj   +1 more source

hemagglutinin trees global xml

, 2014
BEAST xml file used to generate hemagglutinin trees for global analysis (a single ...
Trevor Bedford (376961), Robert J. Woods (175743), Mercedes Pascual (19597), Edward B. Baskerville (189872), Zinder, Daniel, Baskerville, Edward B., Woods, Robert J., Roy, Manojit, Manojit Roy (104218), Bedford, Trevor, Pascual, Mercedes, Daniel Zinder (106377)   +11 more
core   +1 more source