Results 61 to 70 of about 102,208 (283)

A global phylogenetic analysis in order to determine the host species and geography dependent features present in the evolution of avian H9N2 influenza hemagglutinin [PDF]

, 2014
A complete phylogenetic analysis of all of the H9N2 hemagglutinin sequences that were collected between 1966 and 2012 was carried out in order to build a picture of the geographical and host specific evolution of the hemagglutinin protein. To improve the
Andrew R. Dalby, Munir Iqbal, Iqbal, M., Dalby, A.R.   +3 more
core   +1 more source

Phylogenetic Analysis and Characterization of a Sporadic Isolate of Equine Influenza A H3N8 from an Unvaccinated Horse in 2015

Viruses, 2018
Equine influenza, caused by the H3N8 subtype, is a highly contagious respiratory disease affecting equid populations worldwide and has led to serious epidemics and transboundary pandemics.
Chithra C. Sreenivasan, Sunayana S. Jandhyala, Sisi Luo, Ben M. Hause, Milton Thomas, David E. B. Knudsen, Pamela Leslie-Steen, Travis Clement, Stephanie E. Reedy, Thomas M. Chambers, Jane Christopher-Hennings, Eric Nelson, Dan Wang, Radhey S. Kaushik, Feng Li   +14 more
doaj   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

hemagglutinin trees global log file [PDF]

, 2014
Combined log files for hemagglutinin trees generated by BEAST for global ...
Trevor Bedford (376961), Robert J. Woods (175743), Mercedes Pascual (19597), Edward B. Baskerville (189872), Zinder, Daniel, Baskerville, Edward B., Woods, Robert J., Roy, Manojit, Manojit Roy (104218), Bedford, Trevor, Pascual, Mercedes, Daniel Zinder (106377)   +11 more
core   +1 more source

Fusion of a Short HA2-Derived Peptide Sequence to Cell-Penetrating Peptides Improves Cytosolic Uptake, but Enhances Cytotoxic Activity

Pharmaceuticals, 2009
Cell-penetrating peptides (CPP) have become a widely used tool for efficient cargo delivery into cells. However, one limiting fact is their uptake by endocytosis causing the enclosure of the CPP-cargo construct within endosomes.
Igor Kitanovic, Stefan Wölfl, Franziska Schramm, Kristin Löbner, Jan Hoyer, Ines Neundorf, Robert Rennert   +6 more
doaj   +1 more source

Time‐Multiplexed Organic Electrochemical Transistor for Saliva‐Based Rapid Detection of Viral Proteins

Advanced Science, EarlyView.
A time‐multiplexed nanobody‐functionalized organic electrochemical transistor enables rapid and sensitive detection of three respiratory viral proteins from saliva. Sequentially addressed multi‐gate electrodes on a shared channel achieve around 1 fm detection within 15 min without sample preprocessing. Clinical validation demonstrates high specificity,
Tianrui Chang, Yuxiang Ren, Shofarul Wustoni, Atheer Alqatari, Adel Hama, Yazhou Wang, Long Chen, Jessica Parrado Agudelo, Luca Salvigni, Keying Guo, Ashraf Dada, Stefan T. Arold, Raik Grünberg, Sahika Inal   +13 more
wiley   +1 more source

hemagglutinin trees NC/SC/OT [PDF]

, 2014
Hemagglutinin trees generated by BEAST for NC/SC/OT analysis in NEXUS ...
Trevor Bedford (376961), Robert J. Woods (175743), Mercedes Pascual (19597), Edward B. Baskerville (189872), Zinder, Daniel, Baskerville, Edward B., Woods, Robert J., Roy, Manojit, Manojit Roy (104218), Bedford, Trevor, Pascual, Mercedes, Daniel Zinder (106377)   +11 more
core   +1 more source

The Hong Kong Influenza Virus: Treats to the Portrait after 50 Years and the Future Influenza Pandemic

Эпидемиология и вакцинопрофилактика, 2020
Relevance. Of the different subtypes, H3N2 influenza virus subtype has the highest variability and pathogenicity, often dominates in epidemiological seasons and induces high mortality exceeding its rate in pandemic.
E. P. Kharchenko
doaj   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Inactivated influenza virus vaccines expressing COBRA hemagglutinin elicited broadly reactive, long-lived protective antibodies

Human Vaccines & Immunotherapeutics
The influenza viruses cause seasonal respiratory illness that affect millions of people globally every year. Prophylactic vaccines are the recommended method to prevent the breakout of influenza epidemics. One of the current commercial influenza vaccines
Hua Shi, Xiaojian Zhang, Pan Ge, Victoria Meliopoulos, Pam Freiden, Brandi Livingston, Stacey Schultz-Cherry, Ted M. Ross   +7 more
doaj   +1 more source