Results 81 to 90 of about 108,411 (200)

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Computationally Optimized Hemagglutinin Proteins Adjuvanted with Infectimune^® Generate Broadly Protective Antibody Responses in Mice and Ferrets

Vaccines
Background/Objectives: Standard-of-care influenza vaccines contain antigens that are typically derived from components of wild type (WT) influenza viruses.
James D. Allen, Xiaojian Zhang, Jessica M. Medina, Matthew H. Thomas, Amanda Lynch, Ron Nelson, Julia Aguirre, Ted M. Ross   +7 more
doaj   +1 more source

Heterogeneous effects of donor‐related risk factors in 954 pediatric liver transplantations

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Accepting a suitable donor for a child awaiting pediatric liver transplantation (pLT) is increasingly challenging. Donor‐specific risk factors influence post‐transplant outcomes, but evidence in pediatric patients remains inconsistent.
Christoph Leiskau, Norman Junge, Tobias Laue, Imeke Goldschmidt, Frauke E. Mutschler, Moritz Schmelzle, Nicolas Richter, Philipp Felgendreff, Cornelius J. van Beekum, Florian W. R. Vondran, Clara A. Weigle, Eva‐D. Pfister, Ulrich Baumann   +12 more
wiley   +1 more source

The initial structure of CL-385319-hemagglutinin complex.

, 2012
The initial structure of CL-385319-hemagglutinin complex.
Zhibo Zhu (146697), Shuwen Liu (146709), Runming Li (146682), Deshou Song (146688), Hanhong Xu (146703)   +4 more
core   +1 more source

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets [PDF]

, 2016
We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing ...
García-Sastre, Adolfo, Albrecht, Randy A, Miller, Matthew S, Ryder, Alex B, Krammer, Florian, Palese, Peter, Hai, Rong, Nachbagauer, Raffael, Rose, John K   +8 more
core   +1 more source

Toward Predicting Pandemic Potential: A Comparative Analysis of Virus‐Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System

PROTEOMICS, EarlyView.
ABSTRACT Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species‐specific virus‐host interactions, and several host barriers have been identified that restrict the adaptation ...
Antoine Gerodez, Melanie Dos Santos, Mikaël Attia, Killian De Geest, Ibrahim Hamid, Rodrigue Tesse, Ilham Fdillate, Marc Boschmans, Steven Van Borm, Mieke Steensels, Benedicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange   +13 more
wiley   +1 more source

Mapping Allergen B‐ and T‐Cell Epitopes: Technological Advances and Their Role in Precision Allergy Therapy

Allergy, EarlyView.
ABSTRACT Allergic diseases arise from aberrant immune recognition of otherwise harmless environmental proteins and are driven by epitope‐specific interactions between allergens and the adaptive immune system. Although component‐resolved diagnostics have improved molecular characterisation of sensitization, they remain limited to whole‐allergen ...
Mark Møiniche, Josefine Corneliussen, Kristoffer H. Johansen, Alexandre Ruiz‐Carrasco, Caroline Paulsen, Yuchen Li, Carolina Barra, Sandhya Bangaru, Monica L. Fernández‐Quintero, Ewa Bartko, Lars Blom, Esperanza Rivera‐de‐Torre   +11 more
wiley   +1 more source

Proposal for a Global Classification and Nomenclature System for A/H9 Influenza Viruses

Emerging Infectious Diseases
Influenza A/H9 viruses circulate worldwide in wild and domestic avian species, continuing to evolve and posing a zoonotic risk. A substantial increase in human infections with A/H9N2 subtype avian influenza viruses (AIVs) and the emergence of novel ...
Alice Fusaro, Juan Pu, Yong Zhou, Lu Lu, Luca Tassoni, Yu Lan, Tommy Tsan-Yuk Lam, Zoe Song, Justin Bahl, Jiani Chen, George F. Gao, Isabella Monne, Jinhua Liu   +12 more
doaj   +1 more source