Results 91 to 100 of about 102,208 (283)

Hemagglutinin-mediated Influenza Viral Entry: Identification of Molecular Determinants on Host Tropism [PDF]

open access: yes, 2012
Influenza A virus causes seasonal flu in humans and occasionally pandemics in humans and poultry, resulting in high mortality diseases and huge economic loss.
Minxiu Wang (151839)
core  

Live Visualization of Hemagglutinin Dynamics during Infection by Using a Novel Reporter Influenza A Virus

open access: yesViruses, 2020
Live visualization of influenza A virus (IAV) structural proteins during viral infection in cells is highly sought objective to study different aspects of the viral replication cycle. To achieve this, we engineered an IAV to express a Tetra Cysteine tag (
Luiz Gustavo dos Anjos Borges   +4 more
doaj   +1 more source

Humanized immune system animal models and their recent applications

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli   +6 more
wiley   +1 more source

Proinflammatory Epstein–Barr Virus Antibody Functions Track with Disease Activity in Multiple Sclerosis

open access: yesAnnals of Neurology, EarlyView.
Objective Epstein–Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated immunoglobulin G (IgG) titers against EBV nuclear antigen 1 (EBNA1) represent the most consistent serological marker of MS risk, with levels remaining persistently elevated following disease onset.
Malina Behrens   +9 more
wiley   +1 more source

MAbs react with H3 hemagglutinin by western blot. [PDF]

open access: yes, 2013
(A) MAb 12D1 binds the A/Pan/2007/1999 hemagglutinin within the HA2 subunit. mAbs 7A7 and 39A4 do not react with hemagglutinin under reducing conditions.
Peter Palese (59796)   +6 more
core   +1 more source

VARIABILITY OF THE INFLUENZA A VIRUS

open access: yesЮг России: экология, развитие, 2016
Aim. To investigate the mechanisms of variability of the influenza virus.Discussion. Influenza is one of the most significant problems facing the health care system.
I. A. Sobolev   +6 more
doaj   +1 more source

Correlation of Infectivity and Hemagglutinins of Reoviruses

open access: yesExperimental Biology and Medicine, 1968
SummaryAll three reovirus prototypes were grown in MKTC; the infected cultures were maintained at 37° for up to 42 days. During this time period infectivity and HA of the reoviruses were periodically determined. The infectivity of all three types steadily declined to less than 1% of the maximal titer after 30 days.
R, Engler, M T, Fouad
openaire   +2 more sources

Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife

open access: yesBiological Reviews, EarlyView.
ABSTRACT Highly pathogenic avian influenza (HPAI) has become a critical threat to wildlife, shifting from a seasonal epizootic to a persistent, year‐round panzootic with global consequences. Here, we summarise the origin, evolutionary mechanisms, and expanding host range of the current H5N1 virus (clade 2.3.4.4b) and assess its impact on wildlife. Over
Ulrich Knief   +4 more
wiley   +1 more source

Sequence variation in the haemagglutinin-neuraminidase gene of human parainfluenza virus type 3 isolates in the UK [PDF]

open access: yes, 1995
The sequence variation in a 934 base-pair region of the gene encoding the haemagglutinin-neuraminidase of five human parainfluenza virus type 3 (HPIV3) isolates was determined together with that of a prototype UK strain. All of the clinical isolates were
Easton, A. J. (Andrew J.)   +1 more
core   +1 more source

Computationally Optimized Hemagglutinin Proteins Adjuvanted with Infectimune® Generate Broadly Protective Antibody Responses in Mice and Ferrets

open access: yesVaccines
Background/Objectives: Standard-of-care influenza vaccines contain antigens that are typically derived from components of wild type (WT) influenza viruses.
James D. Allen   +7 more
doaj   +1 more source

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