Evolutionarily conserved amino acids in MHC-II mediate bat influenza A virus entry into human cells. [PDF]
PLoS Biology, 2023 The viral hemagglutinins of conventional influenza A viruses (IAVs) bind to sialylated glycans on host cell surfaces for attachment and subsequent infection. In contrast, hemagglutinins of bat-derived IAVs target major histocompatibility complex class II
Okikiola M Olajide +10 more
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A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin substrates. [PDF]
PLoS ONE, 2012 Recently, a new class of broadly neutralizing anti-influenza virus antibodies that target the stalk domain of the viral hemagglutinin was discovered. As such, induction, isolation, characterization, and quantification of these novel antibodies has become
Florian Krammer +5 more
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Structural and Functional Aspects of G-Quadruplex Aptamers Which Bind a Broad Range of Influenza A Viruses [PDF]
Biomolecules, 2020 An aptamer is a synthetic oligonucleotide with a unique spatial structure that provides specific binding to a target. To date, several aptamers to hemagglutinin of the influenza A virus have been described, which vary in affinity and strain specificity ...
Anastasia A. Novoseltseva +9 more
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Strain-specific differences in the response to egg-derived versus recombinant protein influenza vaccines [PDF]
Journal of VirologyThe 2023/2024 influenza vaccine included an updated H1N1 component designed to better match a new clade of H1N1 that had multiple mutations in antigenic epitopes of hemagglutinin.
Andrea N. Loes +15 more
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Molecular Therapy: Nucleic Acids, 2022 Increasing preclinical and clinical results have demonstrated that mRNA vaccines efficiently prevent infectious diseases and are safe in animal models and humans.
Wandi Zhu +7 more
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SOME INVESTIGATIONS ON RABBIT VIRAL HAEMORRHAGIC DISEASE IN UPPER EGYPT [PDF]
Assiut Veterinary Medical Journal, 1994 Rabbit hamorrhagic disease (RHD) outbreaks were observed during winter and spring, 1993 in most rabbitaries of Upper Egypt (Minia, Assiut and Sohage Provinces) with mortality rate of 26.7 up to 100% in4-16 month-old rabbits.
K.EL ZANATY
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The specificity of targeted vaccines for APC surface molecules influences the immune response phenotype. [PDF]
PLoS ONE, 2013 Different diseases require different immune responses for efficient protection. Thus, prophylactic vaccines should prime the immune system for the particular type of response needed for protection against a given infectious agent.
Gunnveig Grødeland +4 more
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npj Vaccines, 2022 There is a crucial need for an improved H3N2 influenza virus vaccine due to low vaccine efficacy rates and increased morbidity and mortality associated with H3N2-dominated influenza seasons.
Brianna L. Bullard +6 more
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Heterosubtypic immunity increases infectious dose required to infect Mallard ducks with Influenza A virus. [PDF]
PLoS ONE, 2018 Previous field and experimental studies have demonstrated that heterosubtypic immunity (HSI) is a potential driver of Influenza A virus (IAV) prevalence and subtype diversity in mallards.
Karen M Segovia +6 more
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Vaccines, 2021 Vaccination is the best way to prevent influenza virus infections, but the diversity of antigenically distinct isolates is a persistent challenge for vaccine development.
Ying Huang +4 more
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