Results 1 to 10 of about 549,420 (237)

Strain-specific differences in the response to egg-derived versus recombinant protein influenza vaccines [PDF]

Journal of Virology
The 2023/2024 influenza vaccine included an updated H1N1 component designed to better match a new clade of H1N1 that had multiple mutations in antigenic epitopes of hemagglutinin.
Andrea N. Loes, Rosario Araceli L. Tarabi, Shuk Hang Li, Reilly K. Atkinson, John Huddleston, Caroline Kikawa, Tachianna Griffiths, Elizabeth M. Drapeau, Sook-San Wong, Samuel M. S. Cheng, Nancy H. L. Leung, Sarah Cobey, Benjamin J. Cowling, Trevor Bedford, Scott E. Hensley, Jesse D. Bloom   +15 more
doaj   +2 more sources

Anti-idiotypic antibodies as molecular mimics of conserved influenza hemagglutinin epitopes. [PDF]

Protein Sci
Abstract Broadly neutralizing antibodies (bNAbs) provide insights for developing universal influenza vaccines through their ability to neutralize diverse viral strains. However, designing antigens that reliably elicit bNAb responses remains challenging due to the difficulty in targeting conserved epitopes with a single antigen.
Itou H, Sano K, Ainai A, Otsuki K, Inoue T, Hemmi T, Hasegawa H, Suzuki T.   +7 more
europepmc   +2 more sources

What Antibody Repertoires See: Structural and Immunogenetic Insights Into Influenza A Virus Hemagglutinin Recognition [PDF]

Immunol Rev
ABSTRACT Human infection with or vaccination against influenza A virus has been one of the most informative systems for understanding how human antibody repertoires recognize viral glycoproteins. Decades of antibody isolation, repertoire sequencing, lineage tracing, serology, viral antigenic evolution, and structural biology have shown that antibody ...
Bonnettaz B, Bajic G.
europepmc   +2 more sources

Evolutionarily conserved amino acids in MHC-II mediate bat influenza A virus entry into human cells.

PLoS Biology, 2023
The viral hemagglutinins of conventional influenza A viruses (IAVs) bind to sialylated glycans on host cell surfaces for attachment and subsequent infection. In contrast, hemagglutinins of bat-derived IAVs target major histocompatibility complex class II
Okikiola M Olajide, Maria Kaukab Osman, Jonathan Robert, Susanne Kessler, Lina Kathrin Toews, Thiprampai Thamamongood, Jacques Neefjes, Antoni G Wrobel, Martin Schwemmle, Kevin Ciminski, Peter Reuther   +10 more
doaj   +1 more source

Structural and Functional Aspects of G-Quadruplex Aptamers Which Bind a Broad Range of Influenza A Viruses

Biomolecules, 2020
An aptamer is a synthetic oligonucleotide with a unique spatial structure that provides specific binding to a target. To date, several aptamers to hemagglutinin of the influenza A virus have been described, which vary in affinity and strain specificity ...
Anastasia A. Novoseltseva, Nikita M. Ivanov, Roman A. Novikov, Yaroslav V. Tkachev, Dmitry A. Bunin, Alexandra S. Gambaryan, Vadim N. Tashlitsky, Alexander M. Arutyunyan, Alexey M. Kopylov, Elena G. Zavyalova   +9 more
doaj   +1 more source

cGAMP-adjuvanted multivalent influenza mRNA vaccines induce broadly protective immunity through cutaneous vaccination in mice

Molecular Therapy: Nucleic Acids, 2022
Increasing preclinical and clinical results have demonstrated that mRNA vaccines efficiently prevent infectious diseases and are safe in animal models and humans.
Wandi Zhu, Lai Wei, Chunhong Dong, Ye Wang, Joo Kim, Yao Ma, Gilbert X. Gonzalez, Bao-Zhong Wang   +7 more
doaj   +1 more source

SOME INVESTIGATIONS ON RABBIT VIRAL HAEMORRHAGIC DISEASE IN UPPER EGYPT [PDF]

Assiut Veterinary Medical Journal, 1994
Rabbit hamorrhagic disease (RHD) outbreaks were observed during winter and spring, 1993 in most rabbitaries of Upper Egypt (Minia, Assiut and Sohage Provinces) with mortality rate of 26.7 up to 100% in4-16 month-old rabbits.
K.EL ZANATY
doaj   +1 more source

The specificity of targeted vaccines for APC surface molecules influences the immune response phenotype. [PDF]

PLoS ONE, 2013
Different diseases require different immune responses for efficient protection. Thus, prophylactic vaccines should prime the immune system for the particular type of response needed for protection against a given infectious agent.
Gunnveig Grødeland, Siri Mjaaland, Gro Tunheim, Agnete B Fredriksen, Bjarne Bogen   +4 more
doaj   +1 more source

An epitope-optimized human H3N2 influenza vaccine induces broadly protective immunity in mice and ferrets

npj Vaccines, 2022
There is a crucial need for an improved H3N2 influenza virus vaccine due to low vaccine efficacy rates and increased morbidity and mortality associated with H3N2-dominated influenza seasons.
Brianna L. Bullard, Jennifer DeBeauchamp, Matthew J. Pekarek, Erika Petro-Turnquist, Peter Vogel, Richard J. Webby, Eric A. Weaver   +6 more
doaj   +1 more source

A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin substrates.

PLoS ONE, 2012
Recently, a new class of broadly neutralizing anti-influenza virus antibodies that target the stalk domain of the viral hemagglutinin was discovered. As such, induction, isolation, characterization, and quantification of these novel antibodies has become
Florian Krammer, Irina Margine, Gene S Tan, Natalie Pica, Jens C Krause, Peter Palese   +5 more
doaj   +1 more source