Results 11 to 20 of about 549,420 (237)

High-complexity extracellular barcoding using a viral hemagglutinin [PDF]

Proceedings of the National Academy of Sciences, 2020
While single-cell sequencing technologies have revealed tissue heterogeneity, resolving mixed cellular libraries into cellular clones is essential for many pooled screens and clonal lineage tracing. Fluorescent proteins are limited in number, while DNA barcodes can only be read after cell lysis.
Mullokandov, Gavriel, Vijayakumar, Gayathri, Leon, Paul, Henry, Carole, Wilson, Patrick C., Krammer, Florian, Palese, Peter, Brown, Brian D.   +7 more
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A simple procedure for purification of viral hemagglutinin [PDF]

Virology, 1962
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/32311/1/0000379 ...
Mizutani, H., Beals, T., Hennessy, A. V., Davenport, Fred M.   +3 more
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Formation of influenza virus particles lacking hemagglutinin on the viral envelope [PDF]

Journal of Virology, 1986
We investigated the intracellular block in the transport of hemagglutinin (HA) and the role of HA in virus particle formation by using temperature-sensitive (ts) mutants (ts134 and ts61S) of influenza virus A/WSN/33. We found that at the nonpermissive temperature (39.5 degrees C), the exit of ts HA from the rough endoplasmic reticulum to the Golgi ...
Pattnaik, Asit K., Brown, Donald J., Nayak, Debi P.   +2 more
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Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity [PDF]

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
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Heterosubtypic immunity increases infectious dose required to infect Mallard ducks with Influenza A virus. [PDF]

PLoS ONE, 2018
Previous field and experimental studies have demonstrated that heterosubtypic immunity (HSI) is a potential driver of Influenza A virus (IAV) prevalence and subtype diversity in mallards.
Karen M Segovia, Monique S França, Christina L Leyson, Darrell R Kapczynski, Klaudia Chrzastek, Charlie S Bahnson, David E Stallknecht   +6 more
doaj   +1 more source

Next Generation of Computationally Optimized Broadly Reactive HA Vaccines Elicited Cross-Reactive Immune Responses and Provided Protection against H1N1 Virus Infection

Vaccines, 2021
Vaccination is the best way to prevent influenza virus infections, but the diversity of antigenically distinct isolates is a persistent challenge for vaccine development.
Ying Huang, Monique S. França, James D. Allen, Hua Shi, Ted M. Ross   +4 more
doaj   +1 more source

Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin [PDF]

Antimicrobial Agents and Chemotherapy, 2003
ABSTRACT The novel antiviral protein cyanovirin-N (CV-N) was initially discovered based on its potent activity against the human immunodeficiency virus (HIV). Subsequent studies identified the HIV envelope glycoproteins gp120 and gp41 as molecular targets of CV-N.
O'Keefe, B. R., Smee, Donald F., Turpin, J. A., Saucedo, C. J., Gustafson, K. R., Mori, T., Blakeslee, D., Buckheit, R., Boyd, M. R.   +8 more
openaire   +3 more sources

Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines [PDF]

, 2011
The hemagglutinins (HAs) of human H1 and H3 influenza viruses and avian H5 influenza virus were produced as recombinant fusion proteins with the human immunoglobulin Fc domain.
Temperton, Nigel J., Ian M. Jones, Christopher R. Bailey, Eleonora Molesti, Ren, Junyuan, Jones, Ian M., Temperton, Nigel J, Silvia Loureiro, Pongsathon Phapugrangkul, Junyuan Ren, Wendy S. Barclay, Camilo A. Colaco, Molesti, Eleonora, Barclay, Wendy S., Shelton, Holly, Colaco, Camilo A, Phapugrangkul, Pongsathon, Nigel J. Temperton, Loureiro, Silvia, Barclay, Wendy S, Bailey, Christopher R, Holly Shelton, Jones, Ian, Colaco, Camilo A., Bailey, Christopher R.   +24 more
core   +1 more source

Enhanced immunogenicity, mortality protection, and reduced viral brain invasion by alum adjuvant with an H5N1 split-virion vaccine in the ferret. [PDF]

PLoS ONE, 2011
Pre-pandemic development of an inactivated, split-virion avian influenza vaccine is challenged by the lack of pre-existing immunity and the reduced immunogenicity of some H5 hemagglutinins compared to that of seasonal influenza vaccines.
Robert Colby Layton, Andrew Gigliotti, Penny Armijo, Leslie Myers, Jennifer Knight, Nathaniel Donart, John Pyles, Sarah Vaughan, Jennifer Plourde, Ndingsa Fomukong, Kevin S Harrod, Peng Gao, Frederick Koster   +12 more
doaj   +1 more source

Stimulation of Heterophil Hemagglutinins in Chickens by a Viral Vaccine and Chicken Thyroid Extract [PDF]

Acta Veterinaria Scandinavica, 1973
The formation of heteroag-glutinins against human group O, horse and sheep erythrocytes was studied in groups of chickens injected with various materials. Production of antibodies cross-reacting with some or all of the test cell types was induced both with chicken thyroid extract, with or without adjuvant, and with inactivated infectious bronchitis ...
D, Sharma, J, Tuomi
openaire   +2 more sources