Results 31 to 40 of about 4,432 (222)

Fluorescent Trimeric Hemagglutinins Reveal Multivalent Receptor Binding Properties [PDF]

, 2019
Influenza A virus carries hundreds of trimeric hemagglutinins proteins (HA) on its viral envelope that interact with various sialylated glycans on a host cell.
Tomris, Ilhan, Afd Chemical Biology and Drug Discovery, Pharmaceutics, Paulson, James C, de Vries, Robert P, dPB I&I, Ward, Andrew B, Chemical Biology and Drug Discovery, Grant, Oliver C, Woods, Robert J, McBride, Ryan, Sub Chemical Biology and Drug Discovery, van der Woude, Roosmarijn, Nemanichvili, Nikoloz, LS Pathologie, Turner, Hannah L, Verheije, Monique H, Afd Pharmaceutics, Aldosari, Mohammed H, Pieters, Roland J, Boons, Geert-Jan   +20 more
core   +1 more source

Revealing the evolution towards complex N-glycan specificities of human H1 influenza A viruses. [PDF]

, 2022
Influenza virus infection remains a threat to human health since viral hemagglutinins are constantly drifting, escaping infec-tion and vaccine-induced antibody responses.
James C, Paulson, Angeles, Canales, Javier, Sastre, Gema, Domínguez, Roosmarijn, van der Woude, Corwin M, Nycholat, Javier, Pérez-Castells, Francisco Javier, Cañada, Robert Paul, de Vries, Jesús, Jiménez-Barbero, Jose M, Orduña, Geert-Jan, Boons   +11 more
core   +1 more source

Hemagglutinin Spatial Distribution Shifts in Response to Cholesterol in the Influenza Viral Envelope [PDF]

Biophysical Journal, 2015
Influenza virus delivers its genome to the host cytoplasm via a process of membrane fusion mediated by the viral hemagglutinin protein. Optimal fusion likely requires multiple hemagglutinin trimers, so the spatial distribution of hemagglutinin on the viral envelope may influence fusion mechanism.
Domanska, Marta K., Dunning, Rebecca A., Dryden, Kelly A., Zawada, Katarzyna E., Yeager, Mark, Kasson, Peter M.   +5 more
openaire   +2 more sources

Influenza hemagglutinin drives viral entry via two sequential intramembrane mechanisms [PDF]

Proceedings of the National Academy of Sciences, 2020
Abstract Enveloped viruses enter cells via a process of membrane fusion between the viral envelope and a cellular membrane. For influenza virus, mutational data have shown that the membrane-inserted portions of the hemagglutinin protein play a critical role in achieving fusion. In contrast to the relatively well-understood ectodomain, a
Anna Pabis, Robert J. Rawle, Peter M. Kasson   +2 more
openaire   +3 more sources

Natural Cytotoxicity Receptors: Pattern Recognition and Involvement of Carbohydrates

The Scientific World Journal, 2005
Natural cytotoxicity receptors (NCRs), expressed by natural killer (NK) cells, trigger NK lysis of tumor and virus-infected cells on interaction with cell-surface ligands of these target cells.
Angel Porgador
doaj   +1 more source

Evolution of the G+C content frontier in the rat cytomegalovirus genome [PDF]

, 2008
Within the 230138 bp of the rat cytomegalovirus (RCMV) genome, the G+C content changes abruptly at position 142644, constituting a G+C content frontier. To the left of this point, overall G+C content is 69.2%, and to the right it is only 47.6%.
Gatherer, Derek, Derek Gatherer
core   +1 more source

Discordant correlation between serological assays observed when measuring heterosubtypic responses against avian influenza H5 and H7 viruses in unexposed individuals [PDF]

, 2014
The human population is constantly exposed to multiple influenza A subtypes due to zoonotic spill over and rapid viral evolution driven by intrinsic error-prone replication and immunological pressure.
Ferrara, Francesca, Temperton, Nigel J., Temperton, Nigel, Lapini, Giulia, Molesti, Eleonora, Montomoli, Emanuele   +5 more
core   +1 more source

Estimating reassortment rates in co-circulating Eurasian swine influenza viruses [PDF]

, 2012
Swine have often been considered as a mixing vessel for different influenza strains. In order to assess their role in more detail, we undertook a retrospective sequencing study to detect and characterize the reassortants present in European swine and to ...
Pybus, OG, McCauley, J. W., Brown, I. H., Kellam, P., Leigh Brown, AJ, Lycett, S., Baillie, G., Baillie, G, Coulter, E, Brown, IH, Wood, JL, Lycett, S. J., Lycett, SJ, Coulter, E., McCauley, JW, Leigh Brown, A., Wood, J. L. N., Pybus, Oliver G., Bhatt, S., Kellam, P, N Wood, J., ?, ?, Wood, JLN, Pybus, Oliver, Brown Leigh, AJ, Bhatt, S, Brown, AJ Leigh, Brown, A. J. Leigh, Pybus, O. G., Brown, I., McCauley, J.   +30 more
core   +1 more source

Revealing the Specificity of Human H1 Influenza A Viruses to Complex N-Glycans [PDF]

, 2023
Influenza virus infection remains a threat to human health since viral hemagglutinins are constantly drifting, escaping infection and vaccine-induced antibody responses.
Afd Chemical Biology and Drug Discovery, Boons, Geert Jan, Spruit, Cindy M., Jiménez-Barbero, Jesús, Chemical Biology and Drug Discovery, Canales, Angeles, Orduña, Jose M., de Vries, Robert P., Bouwman, Kim M., Sastre, Javier, Pérez-Castells, Javier, Sub Chemical Biology and Drug Discovery, van der Woude, Roosmarijn, Cañada, Francisco Javier, Nycholat, Corwin M., Paulson, James C., Domínguez, Gema   +16 more
core   +4 more sources

Highly sensitive detection of influenza virus with SERS aptasensor.

PLoS ONE, 2019
Highly sensitive and rapid technology of surface enhanced Raman scattering (SERS) was applied to create aptasensors for influenza virus detection. SERS achieves 106-109 times signal amplification, yielding excellent sensitivity, whereas aptamers to ...
Vladimir I Kukushkin, Nikita M Ivanov, Anastasia A Novoseltseva, Alexandra S Gambaryan, Igor V Yaminsky, Alexey M Kopylov, Elena G Zavyalova   +6 more
doaj   +1 more source