Results 21 to 30 of about 549,420 (237)

Characterization of the sialic acid binding activity of influenza A viruses using soluble variants of the H7 and H9 hemagglutinins.

PLoS ONE, 2014
Binding of influenza viruses to target cells is mediated by the viral surface protein hemagglutinin. To determine the presence of binding sites for influenza A viruses on cells and tissues, soluble hemagglutinins of the H7 and H9 subtype were generated ...
Anne-Kathrin Sauer, Chi-Hui Liang, Jürgen Stech, Ben Peeters, Pascale Quéré, Christel Schwegmann-Wessels, Chung-Yi Wu, Chi-Huey Wong, Georg Herrler   +8 more
doaj   +1 more source

Antibody-Based Strategies to Prevent and Treat Influenza

Frontiers in Immunology, 2015
Passive immunization using antibodies has been suggested to offer several benefits in comparison to other antiviral treatment options. The potential for seasonal protection arising from a single injection of antibodies is appealing and has been pursued ...
Ram eSasisekharan, Zachary eShriver
doaj   +1 more source

Highly pathogenic H5N1 influenza viruses carry virulence determinants beyond the polybasic hemagglutinin cleavage site. [PDF]

PLoS ONE, 2010
Highly pathogenic avian influenza viruses (HPAIV) originate from avirulent precursors but differ from all other influenza viruses by the presence of a polybasic cleavage site in their hemagglutinins (HA) of subtype H5 or H7.
Jessica Bogs, Jutta Veits, Sandra Gohrbandt, Jana Hundt, Olga Stech, Angele Breithaupt, Jens P Teifke, Thomas C Mettenleiter, Jürgen Stech   +8 more
doaj   +1 more source

Recognition of viral hemagglutinins by NKp44 but not by NKp30

European Journal of Immunology, 2001
Natural killer (NK) cells destroy virus-infected and tumor cells without prior antigen stimulation. The NK cell cytotoxicity is regulated in large part by the expression of NK cell receptors that are able to bind major histocompatibility complex (MHC) class I glycoproteins.
Arnon, T, Lev, M, Katz, G, Chernobrov, Y, Porgador, A, Mandelboim, O   +5 more
openaire   +3 more sources

Structural Basis for Influence of Viral Glycans on Ligand Binding by Influenza Hemagglutinin [PDF]

Biophysical Journal, 2008
Binding of cell surface glycans by influenza hemagglutinin controls viral attachment and infection of host cells. This binding is a three-way interaction between viral proteins, host glycans, and viral glycans; many structural details of this interaction have been difficult to resolve.
Kasson, Peter M., Pande, Vijay S.
openaire   +2 more sources

Influenza hemagglutinin drives viral entry via two sequential intramembrane mechanisms [PDF]

Proceedings of the National Academy of Sciences, 2020
Abstract Enveloped viruses enter cells via a process of membrane fusion between the viral envelope and a cellular membrane. For influenza virus, mutational data have shown that the membrane-inserted portions of the hemagglutinin protein play a critical role in achieving fusion. In contrast to the relatively well-understood ectodomain, a
Anna Pabis, Robert J. Rawle, Peter M. Kasson   +2 more
openaire   +3 more sources

The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection [PDF]

Nature Communications, 2020
AbstractThe emergence of drug-resistant influenza type A viruses (IAVs) necessitates the development of novel anti-IAV agents. Here, we target the IAV hemagglutinin (HA) protein using multivalent peptide library screens and identify PVF-tet, a peptide-based HA inhibitor.
Jumpei Omi, Miho Watanabe-Takahashi, Katsura Igai, Eiko Shimizu, Ching-Yi Tseng, Tomohiro Miyasaka, Tsuyoshi Waku, Shinichiro Hama, Rieka Nakanishi, Yuki Goto, Yuri Nishino, Atsuo Miyazawa, Yasuhiro Natori, Makoto Yamashita, Kiyotaka Nishikawa   +14 more
openaire   +3 more sources

Hemagglutinin Spatial Distribution Shifts in Response to Cholesterol in the Influenza Viral Envelope [PDF]

Biophysical Journal, 2015
Influenza virus delivers its genome to the host cytoplasm via a process of membrane fusion mediated by the viral hemagglutinin protein. Optimal fusion likely requires multiple hemagglutinin trimers, so the spatial distribution of hemagglutinin on the viral envelope may influence fusion mechanism.
Domanska, Marta K., Dunning, Rebecca A., Dryden, Kelly A., Zawada, Katarzyna E., Yeager, Mark, Kasson, Peter M.   +5 more
openaire   +2 more sources

Natural Cytotoxicity Receptors: Pattern Recognition and Involvement of Carbohydrates

The Scientific World Journal, 2005
Natural cytotoxicity receptors (NCRs), expressed by natural killer (NK) cells, trigger NK lysis of tumor and virus-infected cells on interaction with cell-surface ligands of these target cells.
Angel Porgador
doaj   +1 more source

The Host Cell Receptors for Measles Virus and Their Interaction with the Viral Hemagglutinin (H) Protein [PDF]

Viruses, 2016
The hemagglutinin (H) protein of measles virus (MeV) interacts with a cellular receptor which constitutes the initial stage of infection. Binding of H to this host cell receptor subsequently triggers the F protein to activate fusion between virus and host plasma membranes.
Liang-Tzung Lin, Christopher D. Richardson   +1 more
openaire   +3 more sources