Results 21 to 30 of about 4,432 (222)

Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk [PDF]

, 2012
Natural killer (NK) cells play a critical role in antitumor immunity, their activation being regulated through NK cell receptors. Although the endogenous ligands for these receptors are largely unknown, viral ligands have been identified. We investigated
Bateman, Andrew R, Elliott, Tim, James, Edward, Chinnery, Fay, King, Catherine A   +4 more
core   +1 more source

Enhanced immunogenicity, mortality protection, and reduced viral brain invasion by alum adjuvant with an H5N1 split-virion vaccine in the ferret. [PDF]

PLoS ONE, 2011
Pre-pandemic development of an inactivated, split-virion avian influenza vaccine is challenged by the lack of pre-existing immunity and the reduced immunogenicity of some H5 hemagglutinins compared to that of seasonal influenza vaccines.
Robert Colby Layton, Andrew Gigliotti, Penny Armijo, Leslie Myers, Jennifer Knight, Nathaniel Donart, John Pyles, Sarah Vaughan, Jennifer Plourde, Ndingsa Fomukong, Kevin S Harrod, Peng Gao, Frederick Koster   +12 more
doaj   +1 more source

Stimulation of Heterophil Hemagglutinins in Chickens by a Viral Vaccine and Chicken Thyroid Extract [PDF]

Acta Veterinaria Scandinavica, 1973
The formation of heteroag-glutinins against human group O, horse and sheep erythrocytes was studied in groups of chickens injected with various materials. Production of antibodies cross-reacting with some or all of the test cell types was induced both with chicken thyroid extract, with or without adjuvant, and with inactivated infectious bronchitis ...
D, Sharma, J, Tuomi
openaire   +2 more sources

Antibody-Based Strategies to Prevent and Treat Influenza

Frontiers in Immunology, 2015
Passive immunization using antibodies has been suggested to offer several benefits in comparison to other antiviral treatment options. The potential for seasonal protection arising from a single injection of antibodies is appealing and has been pursued ...
Ram eSasisekharan, Zachary eShriver
doaj   +1 more source

Highly pathogenic H5N1 influenza viruses carry virulence determinants beyond the polybasic hemagglutinin cleavage site. [PDF]

PLoS ONE, 2010
Highly pathogenic avian influenza viruses (HPAIV) originate from avirulent precursors but differ from all other influenza viruses by the presence of a polybasic cleavage site in their hemagglutinins (HA) of subtype H5 or H7.
Jessica Bogs, Jutta Veits, Sandra Gohrbandt, Jana Hundt, Olga Stech, Angele Breithaupt, Jens P Teifke, Thomas C Mettenleiter, Jürgen Stech   +8 more
doaj   +1 more source

Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin [PDF]

Antimicrobial Agents and Chemotherapy, 2003
ABSTRACT The novel antiviral protein cyanovirin-N (CV-N) was initially discovered based on its potent activity against the human immunodeficiency virus (HIV). Subsequent studies identified the HIV envelope glycoproteins gp120 and gp41 as molecular targets of CV-N.
O'Keefe, B. R., Smee, Donald F., Turpin, J. A., Saucedo, C. J., Gustafson, K. R., Mori, T., Blakeslee, D., Buckheit, R., Boyd, M. R.   +8 more
openaire   +3 more sources

The structure of Herpesvirus Fusion Glycoprotein B-Bilayer Complex reveals the protein-membrane and lateral protein-protein interaction [PDF]

, 2013
Glycoprotein B (gB) is a key component of the complex herpesvirus fusion machinery. We studied membrane interaction of two gB ectodomain forms and present an electron cryotomography structure of the gB-bilayer complex.
Topf, Maya, Huiskonen, JT, Topf, M., Maurer, U., Whitbeck, J., Maurer, U.E., Gruenewald, Kay, Cohen, G., Cairns, T.M., Eisenberg, R.J., Huiskonen, Juha T., Whitbeck, J.C., Zeev-Ben-Mordehai, T, Cohen, Gary H., Cohen, GH, Cairns, Tina M., Hannah, BP, Hannah, B.P., Cohen, G.H., Pandurangan, A., Zeev-Ben-Mordehai, T., Grünewald, K, Eisenberg, Roselyn J., Cairns, T., Huiskonen, J.T., Maurer, Ulrike E., Grünewald, Kay, Eisenberg, RJ, Topf, M, Grünewald, K., Maurer, UE, Pandurangan, Arun Prasad, Whitbeck, JC, Zeev-Ben-Mordehai, Tzviya, Huiskonen, J., Hannah, Brian P., Hannah, B., Pandurangan, Arun, Pandurangan, AP, Eisenberg, R., Whitbeck, J. Charles, Cairns, TM   +41 more
core   +2 more sources

Polymer-Stabilized Sialylated Nanoparticles: Synthesis, Optimization, and Differential Binding to Influenza Hemagglutinins [PDF]

, 2020
During influenza infection, hemagglutinins (HAs) on the viral surface bind to sialic acids on the host cell’s surface. While all HAs bind sialic acids, human influenza targets terminal α2,6 sialic acids and avian influenza targets α2,3 sialic acids.
Sarah-Jane Richards, Marc Walker, Alexander N. Baker, Sarah-Jane Richards (1733644), Alexander N. Baker (8647908), Matthew I. Gibson, Marc Walker (1429663), Matthew I. Gibson (1273788)   +7 more
core   +1 more source

The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection [PDF]

Nature Communications, 2020
AbstractThe emergence of drug-resistant influenza type A viruses (IAVs) necessitates the development of novel anti-IAV agents. Here, we target the IAV hemagglutinin (HA) protein using multivalent peptide library screens and identify PVF-tet, a peptide-based HA inhibitor.
Jumpei Omi, Miho Watanabe-Takahashi, Katsura Igai, Eiko Shimizu, Ching-Yi Tseng, Tomohiro Miyasaka, Tsuyoshi Waku, Shinichiro Hama, Rieka Nakanishi, Yuki Goto, Yuri Nishino, Atsuo Miyazawa, Yasuhiro Natori, Makoto Yamashita, Kiyotaka Nishikawa   +14 more
openaire   +3 more sources

Overview of Serological Techniques for Influenza Vaccine Evaluation: Past, Present and Future [PDF]

, 2014
Serological techniques commonly used to quantify influenza-specific antibodies include the Haemagglutination Inhibition (HI), Single Radial Haemolysis (SRH) and Virus Neutralization (VN) assays.
Temperton, Nigel J., Claudia Trombetta, Emanuele Montomoli, Trombetta, Claudia Maria, Stuart Mather, Perini, Daniele, Daniele Perini, Claudia Maria Trombetta, Mather, Stuart, Temperton, Nigel, Trombetta, Claudia, Nigel Temperton, Montomoli, Emanuele   +12 more
core   +1 more source