Results 21 to 30 of about 6,736 (217)
npj Vaccines, 2022 There is a crucial need for an improved H3N2 influenza virus vaccine due to low vaccine efficacy rates and increased morbidity and mortality associated with H3N2-dominated influenza seasons.
Brianna L. Bullard +6 more
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Heterosubtypic immunity increases infectious dose required to infect Mallard ducks with Influenza A virus. [PDF]
PLoS ONE, 2018 Previous field and experimental studies have demonstrated that heterosubtypic immunity (HSI) is a potential driver of Influenza A virus (IAV) prevalence and subtype diversity in mallards.
Karen M Segovia +6 more
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Vaccines, 2021 Vaccination is the best way to prevent influenza virus infections, but the diversity of antigenically distinct isolates is a persistent challenge for vaccine development.
Ying Huang +4 more
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Formation of influenza virus particles lacking hemagglutinin on the viral envelope [PDF]
Journal of Virology, 1986 We investigated the intracellular block in the transport of hemagglutinin (HA) and the role of HA in virus particle formation by using temperature-sensitive (ts) mutants (ts134 and ts61S) of influenza virus A/WSN/33. We found that at the nonpermissive temperature (39.5 degrees C), the exit of ts HA from the rough endoplasmic reticulum to the Golgi ...
Pattnaik, Asit K. +2 more
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PLoS ONE, 2012 Recently, a new class of broadly neutralizing anti-influenza virus antibodies that target the stalk domain of the viral hemagglutinin was discovered. As such, induction, isolation, characterization, and quantification of these novel antibodies has become
Florian Krammer +5 more
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Enhanced immunogenicity, mortality protection, and reduced viral brain invasion by alum adjuvant with an H5N1 split-virion vaccine in the ferret. [PDF]
PLoS ONE, 2011 Pre-pandemic development of an inactivated, split-virion avian influenza vaccine is challenged by the lack of pre-existing immunity and the reduced immunogenicity of some H5 hemagglutinins compared to that of seasonal influenza vaccines.
Robert Colby Layton +12 more
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Highly pathogenic H5N1 influenza viruses carry virulence determinants beyond the polybasic hemagglutinin cleavage site. [PDF]
PLoS ONE, 2010 Highly pathogenic avian influenza viruses (HPAIV) originate from avirulent precursors but differ from all other influenza viruses by the presence of a polybasic cleavage site in their hemagglutinins (HA) of subtype H5 or H7.
Jessica Bogs +8 more
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The production and development of H7 Influenza virus pseudotypes for the study of humoral responses against avian viruses [PDF]
, 2013 In recent years, high pathogenicity avian influenza (HPAI) virus, H5N1, low pathogenicity avian influenza (LPAI) virus, H9N2, and both HPAI and LPAI H7 viruses have proved devastating for the affected economies reliant on poultry industry, and have posed
Böttcher-Frieberthäuser, Eva +5 more
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Structural Basis for Influence of Viral Glycans on Ligand Binding by Influenza Hemagglutinin [PDF]
Biophysical Journal, 2008 Binding of cell surface glycans by influenza hemagglutinin controls viral attachment and infection of host cells. This binding is a three-way interaction between viral proteins, host glycans, and viral glycans; many structural details of this interaction have been difficult to resolve.
Kasson, Peter M., Pande, Vijay S.
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PLoS ONE, 2014 Binding of influenza viruses to target cells is mediated by the viral surface protein hemagglutinin. To determine the presence of binding sites for influenza A viruses on cells and tissues, soluble hemagglutinins of the H7 and H9 subtype were generated ...
Anne-Kathrin Sauer +8 more
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