Recent progress in chemical approaches for the development of novel neuraminidase inhibitors
RSC Advances, 2021 Influenza virus is the main cause of an infectious disease called influenza affecting the respiratory system including the throat, nose and lungs.
A. Mahal +10 more
semanticscholar +1 more source
Tropical Animal Science Journal, 2023 In recent decades, neuraminidase/sialidase-based antivirals have been produced to suppress respiratory viral infections, including avian influenza, which relies on sialic acid as the entry point for viruses into cells.
O. N. Poetri +9 more
doaj +1 more source
Overview of Serological Techniques for Influenza Vaccine Evaluation: Past, Present and Future [PDF]
, 2014 Serological techniques commonly used to quantify influenza-specific antibodies include the Haemagglutination Inhibition (HI), Single Radial Haemolysis (SRH) and Virus Neutralization (VN) assays.
Callow +30 more
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A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase. [PDF]
PLoS ONE, 2011 The His274→Tyr (H274Y) oseltamivir (Tamiflu) resistance mutation causes a substantial decrease in the total levels of surface-expressed neuraminidase protein and activity in early isolates of human seasonal H1N1 influenza, and in the swine-origin ...
Jesse D Bloom +2 more
doaj +1 more source
Psychiatric adverse events in oseltamivir prophylaxis trials: Novel comparative analysis using data obtained from clinical study reports [PDF]
, 2018 PURPOSE: Estimating the rate of adverse events (AEs) caused by a treatment in clinical trials typically involves comparing the proportions of patients experiencing AEs in intervention and control groups.
Bender +12 more
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Influenza Virus Neuraminidase Structure and Functions
Frontiers in Microbiology, 2019 With the constant threat of emergence of a novel influenza virus pandemic, there must be continued evaluation of the molecular mechanisms that contribute to virulence.
J. McAuley +4 more
semanticscholar +1 more source
Antivirals Targeting the Neuraminidase.
Cold Spring Harbor Perspectives in Medicine, 2020 The neuraminidase (NA) of influenza A and B viruses plays a distinct role in viral replication and has a highly conserved catalytic site. Numerous sialic (neuraminic) acid analogs that competitively bind to the NA active site and potently inhibit enzyme ...
L. Gubareva, T. Mohan
semanticscholar +1 more source
Influenza A nucleoprotein binding sites for antivirals: current research and future potential [PDF]
, 2014 This document is the Accepted Manuscript version of the following article: Andreas Kukol and Hershna Patel, ‘Influenza A nucleoprotein binding sites for antivirals: current research and future potential’, Future Biology, Vol 9(7): 625-627, July 2014. The
Kukol, A, Kukol, A, Patel, H., Patel, H.
core +2 more sources
Broadly protective human antibodies that target the active site of influenza virus neuraminidase
Science, 2019 Alternative influenza target There is a pressing need for a broadly protective influenza vaccine that can neutralize this constantly varying, deadly virus. Stadlbauer et al.
D. Stadlbauer +12 more
semanticscholar +1 more source
Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies [PDF]
, 2016 There is mounting evidence that in the absence of neutralizing antibodies cross-reactive T cells provide protection against pandemic influenza viruses. Here, we compared protection and CD8+ T cell responses following challenge with H1N1 2009 pandemic and
Callewaert, Nico +9 more
core +2 more sources