Results 21 to 30 of about 52,033 (201)

NAction! How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines?

mBio, 2018
Neuraminidase is one of the two surface glycoproteins of influenza A and B viruses. It has enzymatic activity that cleaves terminal sialic acid from glycans, and that activity is essential at several points in the virus life cycle. While neuraminidase is
Florian Krammer, Ron A. M. Fouchier, Maryna C. Eichelberger, Richard J. Webby, Kathryn Shaw-Saliba, Hongquan Wan, Patrick C. Wilson, Richard W. Compans, Ioanna Skountzou, Arnold S. Monto   +9 more
doaj   +1 more source

Microglia activated by microbial neuraminidase contributes to ependymal cell death

Fluids and Barriers of the CNS, 2021
The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of this model.
María del Mar Fernández-Arjona, Ana León-Rodríguez, María Dolores López-Ávalos, Jesús M. Grondona   +3 more
doaj   +1 more source

Limited Hydrolysis of Polysialic Acid by Human Neuraminidase Enzymes [PDF]

, 2021
Regulation of sialic acids by human neuraminidase (hNEU) enzymes is important to many biological processes. Defining hNEU substrate tolerance can help to elucidate the roles of these enzymes in regulating sialosides in human health and disease ...
Carmanah D., Hunter, Christopher, Cairo
core   +2 more sources

Characterization of the hemagglutinin receptor specificity and neuraminidase substrate specificity of clinical isolates of human influenza A viruses

Memorias do Instituto Oswaldo Cruz, 1994
Six clinical isolates of influenza A viruses were examined for hemagglutinin receptor specificity and neuraminidase substrate specificity. All of the viral isolates minimally passaged in mammalian cells demonstrated preferential agglutination of human ...
J. N. S. S. Couceiro, L. G. Baum
doaj   +1 more source

Self-amplifying mRNA bicistronic influenza vaccines raise cross-reactive immune responses in mice and prevent infection in ferrets

Molecular Therapy: Methods & Clinical Development, 2022
Vaccines are the primary intervention against influenza. Currently licensed inactivated vaccines focus immunity on viral hemagglutinin (HA). Self-amplifying mRNA (sa-mRNA) vaccines offer an opportunity to generate immunity to multiple viral proteins ...
Cheng Chang, Nedzad Music, Michael Cheung, Evan Rossignol, Sukhmani Bedi, Harsh Patel, Mohammad Safari, Changkeun Lee, Gillis R. Otten, Ethan C. Settembre, Giuseppe Palladino, Yingxia Wen   +11 more
doaj   +1 more source

Structural characterization of the carbohydrate-binding module of NanA sialidase, a pneumococcal virulence factor [PDF]

, 2015
This research was supported by the University of St Andrews and grants provided by the Medical Research Council.Background: Streptococcus pneumoniae Neuraminidase A (NanA) is a multi-domain protein anchored to the bacterial surface.
Helen Connaris, Yang, Lei, Garry L. Taylor, Taylor, Garry Lindsay, Lei Yang, Potter, Jane Alexandra, Connaris, Helen, Jane A. Potter   +7 more
core   +1 more source

Influenza Neuraminidase Inhibitors: Synthetic Approaches, Derivatives and Biological Activity

Molecules, 2016
Despite being a common viral disease, influenza has very negative consequences, causing the death of around half a million people each year. A neuraminidase located on the surface of the virus plays an important role in viral reproduction by contributing
Pedro Laborda, Su-Yan Wang, Josef Voglmeir   +2 more
doaj   +1 more source

Meeting Report: Risk Assessment of Tamiflu® use under Pandemic Conditions [PDF]

, 2008
On 3 October 2007, 40 participants with diverse expertise attended the workshop Tamiflu and the Environment: Implications of Use under Pandemic Conditions to assess the potential human health impact and environmental hazards associated with use of ...
Howard B. M., Saccà M. L., Boucard, Tatiana, Vouivoulis, N, Costigan S., Alistair Boxall, Costigan, S, John Churchley, Marsden P., Bird, S, Watts, Chris, Fick J., Johnson, Andrew C., Michael J. Dempsey, Bird S., Dempsey M. J., Knowles, CJ, Boucard, T, Townsend, Rodney, Jerker Fick, Straub, Jurg Oliver, Holmes J., Noone, Gerald, Voulvoulis N., Hutchinson T., Fick, J, Crane M., Maria Ludovica Saccà, Chubb C., Howard, BM, John Oxford, Voulvoulis, Nikolaos, Vouivoulis, Nikolaos, Cesare Accinelli, Noel Roberts, Peter Marsden, Barra Caracciolo A., Straub, JO, Kellher, Samuel L., Ellor, B, Boucard T., Cartmell, E, Sandra Costigan, Watts C., Sacca, Maria Ludovica, Roberts N., Noone, G, Hutchinson, Tom, Sanders M., Nunn, Miles A., John Holmes, Knowles, Chris J., Rodney Townsend, Simon Jackman, Chris Watts, Brian, Jayne V., Fick, Jerker, Marsden, Peter, Costigan, Sandra, Toovey, Stephen, Boxall, Alistair, Sanders, Matthew, Accinelli, C, Caracciolo, AB, Jackman, Simon, Marsden, P, Bob Dorrington, Accinelli, Cesare, Roberts, Noel, Stephen Bird, Bernard I, Sacca, ML, Chris J. Knowles, Jackman S., Dean Thomas, Jackman, S, Ellor, Brian, Karcher F., Bird, Stephen, Chris Chubb, Voulvoulis, N, Boxall A., Townsend, R, Howard, Bruce M., Sanders, M, Johnson A. C., Churchley, John, Dempsey, MJ, Andrew C. Johnson, Rachwal, T, Tatiana Boucard, Crane, Mark, Andrew C. Singer, Wells, Ursula, Terry A., Tony Rachwal, Jayne V. Brian, Stephen Toovey, Churchley, J, Miles A. Nunn, Dorrington, B, Toovey, S, Singer A. C., Dorrington B., Brian, JV, Thomas D., Toovey S., Dempsey, Michael J., Watts, C, Roberts M., Boxall, A, Tom Hutchinson, Matthew Sanders, Nikolaos Voulvoulis, Kelleher S. L., Roberts, Mike, Churchley J., Bernard, Ian, Townsend R., Cartmell, Elise, Franz Karcher, Karcher, Franz, Singer, Andrew C., Bruce M. Howard, Gerald Noone, Thomas, Dean, Nunn, MA, Anna Barra Caracciolo, Oxford J., Oxford, John, Holmes, J, Holmes, John, Churchley, J., Singer, AC, Jürg Oliver Straub, Hutchinson, T, Samuel L. Kelleher, Chubb, C, Boxall, Alastair, Knowles C. J., Nunn M. A., Mike Roberts, Oxford, J, Chubb, Chris, Rachwal, Tony, Bernard, I, Elise Cartmell, Dorrington, Bob, Thomas, D, Kelleher, SL, Brian J. V., Cartmell E., Rachwal T., Voulvoulis, Nick, Johnson, AC, Crane, M, Ian Bernard, Adrian Terry, Mark Crane, Caracciolo, Anna Barra, Roberts, M, Roberts, N, Straub J. O., Kelleher, Samuel L., Terry, Adrian, Noone G., Karcher, F, Wells U., Terry, A, Brian Ellor, Barra Caracciolo, Anna   +170 more
core   +1 more source

Multidrug-Resistant Pandemic (H1N1) 2009 Infection in Immunocompetent Child

Emerging Infectious Diseases, 2011
Recent case reports describe multidrug-resistant influenza A pandemic (H1N1) 2009 virus infection in immunocompromised patients exposed to neuraminidase inhibitors because of an I223R neuraminidase mutation.
Alireza Eshaghi, Samir N. Patel, Alicia Sarabia, Rachel R. Higgins, Alexei Savchenko, Peter J. Stojios, Yan Li, Nathalie Bastien, David C. Alexander, Donald E. Low, Jonathan B. Gubbay   +10 more
doaj   +1 more source

An Overview of Influenza Viruses and Vaccines

Vaccines, 2021
Influenza remains one of the major public health concerns because it causes annual epidemics and can potentially instigate a global pandemic. Numerous countermeasures, including vaccines and antiviral treatments, are in use against seasonal influenza ...
Rina Fajri Nuwarda, Abdulsalam Abdullah Alharbi, Veysel Kayser   +2 more
doaj   +1 more source