Results 31 to 40 of about 48,869 (270)

Homology modelling and insilico analysis of neuraminidase protein in H1N1 Influenza A virus

Brazilian Archives of Biology and Technology, 2011
In this work, modelling of Neuraminidase protein of Influenza A virus (A/Himeji/1/2009(H1N1)) neuraminidase (NA) protein was done using Modeller 9V2.
Abhilash Manohar
doaj   +1 more source

Microglia activated by microbial neuraminidase contributes to ependymal cell death

Fluids and Barriers of the CNS, 2021
The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of this model.
María del Mar Fernández-Arjona, Ana León-Rodríguez, María Dolores López-Ávalos, Jesús M. Grondona   +3 more
doaj   +1 more source

Neuraminidase in Bacteroides fragilis [PDF]

Applied and Environmental Microbiology, 1983
A neuraminidase from Bacteroides fragilis was purified 542-fold by isoelectric focusing, adsorption chromatography on Affi-Gel 202, and gel filtration chromatography on Sephadex G-200. On isoelectric focusing the neuraminidase was resolved into three differently charged fractions with pI values of 6.8, 7.1, and 7.4.
J O, Berg, L, Lindqvist, G, Andersson, C E, Nord   +3 more
openaire   +2 more sources

Characterization of the hemagglutinin receptor specificity and neuraminidase substrate specificity of clinical isolates of human influenza A viruses

Memorias do Instituto Oswaldo Cruz, 1994
Six clinical isolates of influenza A viruses were examined for hemagglutinin receptor specificity and neuraminidase substrate specificity. All of the viral isolates minimally passaged in mammalian cells demonstrated preferential agglutination of human ...
J. N. S. S. Couceiro, L. G. Baum
doaj   +1 more source

Influenza A Virus Hemagglutinin–Neuraminidase–Receptor Balance: Preserving Virus Motility

Trends in Microbiology, 2019
Influenza A viruses (IAVs) occasionally cross the species barrier and adapt to novel host species. This requires readjustment of the functional balance of the sialic acid receptor-binding hemagglutinin (HA) and the receptor-destroying neuraminidase (NA ...
E. de Vries, Wenjuan Du, Hongbo Guo, C. D. de Haan   +3 more
semanticscholar   +1 more source

Self-amplifying mRNA bicistronic influenza vaccines raise cross-reactive immune responses in mice and prevent infection in ferrets

Molecular Therapy: Methods & Clinical Development, 2022
Vaccines are the primary intervention against influenza. Currently licensed inactivated vaccines focus immunity on viral hemagglutinin (HA). Self-amplifying mRNA (sa-mRNA) vaccines offer an opportunity to generate immunity to multiple viral proteins ...
Cheng Chang, Nedzad Music, Michael Cheung, Evan Rossignol, Sukhmani Bedi, Harsh Patel, Mohammad Safari, Changkeun Lee, Gillis R. Otten, Ethan C. Settembre, Giuseppe Palladino, Yingxia Wen   +11 more
doaj   +1 more source

Multidrug-Resistant Pandemic (H1N1) 2009 Infection in Immunocompetent Child

Emerging Infectious Diseases, 2011
Recent case reports describe multidrug-resistant influenza A pandemic (H1N1) 2009 virus infection in immunocompromised patients exposed to neuraminidase inhibitors because of an I223R neuraminidase mutation.
Alireza Eshaghi, Samir N. Patel, Alicia Sarabia, Rachel R. Higgins, Alexei Savchenko, Peter J. Stojios, Yan Li, Nathalie Bastien, David C. Alexander, Donald E. Low, Jonathan B. Gubbay   +10 more
doaj   +1 more source

Meeting Report: Risk Assessment of Tamiflu® use under Pandemic Conditions [PDF]

, 2008
On 3 October 2007, 40 participants with diverse expertise attended the workshop Tamiflu and the Environment: Implications of Use under Pandemic Conditions to assess the potential human health impact and environmental hazards associated with use of ...
Howard B. M., Saccà M. L., Boucard, Tatiana, Vouivoulis, N, Costigan S., Alistair Boxall, Costigan, S, John Churchley, Marsden P., Bird, S, Watts, Chris, Fick J., Johnson, Andrew C., Michael J. Dempsey, Bird S., Dempsey M. J., Knowles, CJ, Boucard, T, Townsend, Rodney, Jerker Fick, Straub, Jurg Oliver, Holmes J., Noone, Gerald, Voulvoulis N., Hutchinson T., Fick, J, Crane M., Maria Ludovica Saccà, Chubb C., Howard, BM, John Oxford, Voulvoulis, Nikolaos, Vouivoulis, Nikolaos, Cesare Accinelli, Noel Roberts, Peter Marsden, Barra Caracciolo A., Straub, JO, Kellher, Samuel L., Ellor, B, Boucard T., Cartmell, E, Sandra Costigan, Watts C., Sacca, Maria Ludovica, Roberts N., Noone, G, Hutchinson, Tom, Sanders M., Nunn, Miles A., John Holmes, Knowles, Chris J., Rodney Townsend, Simon Jackman, Chris Watts, Brian, Jayne V., Fick, Jerker, Marsden, Peter, Costigan, Sandra, Toovey, Stephen, Boxall, Alistair, Sanders, Matthew, Accinelli, C, Caracciolo, AB, Jackman, Simon, Marsden, P, Bob Dorrington, Accinelli, Cesare, Roberts, Noel, Stephen Bird, Bernard I, Sacca, ML, Chris J. Knowles, Jackman S., Dean Thomas, Jackman, S, Ellor, Brian, Karcher F., Bird, Stephen, Chris Chubb, Voulvoulis, N, Boxall A., Townsend, R, Howard, Bruce M., Sanders, M, Johnson A. C., Churchley, John, Dempsey, MJ, Andrew C. Johnson, Rachwal, T, Tatiana Boucard, Crane, Mark, Andrew C. Singer, Wells, Ursula, Terry A., Tony Rachwal, Jayne V. Brian, Stephen Toovey, Churchley, J, Miles A. Nunn, Dorrington, B, Toovey, S, Singer A. C., Dorrington B., Brian, JV, Thomas D., Toovey S., Dempsey, Michael J., Watts, C, Roberts M., Boxall, A, Tom Hutchinson, Matthew Sanders, Nikolaos Voulvoulis, Kelleher S. L., Roberts, Mike, Churchley J., Bernard, Ian, Townsend R., Cartmell, Elise, Franz Karcher, Karcher, Franz, Singer, Andrew C., Bruce M. Howard, Gerald Noone, Thomas, Dean, Nunn, MA, Anna Barra Caracciolo, Oxford J., Oxford, John, Holmes, J, Holmes, John, Churchley, J., Singer, AC, Jürg Oliver Straub, Hutchinson, T, Samuel L. Kelleher, Chubb, C, Boxall, Alastair, Knowles C. J., Nunn M. A., Mike Roberts, Oxford, J, Chubb, Chris, Rachwal, Tony, Bernard, I, Elise Cartmell, Dorrington, Bob, Thomas, D, Kelleher, SL, Brian J. V., Cartmell E., Rachwal T., Voulvoulis, Nick, Johnson, AC, Crane, M, Ian Bernard, Adrian Terry, Mark Crane, Caracciolo, Anna Barra, Roberts, M, Roberts, N, Straub J. O., Kelleher, Samuel L., Terry, Adrian, Noone G., Karcher, F, Wells U., Terry, A, Brian Ellor, Barra Caracciolo, Anna   +170 more
core   +1 more source

An Overview of Influenza Viruses and Vaccines

Vaccines, 2021
Influenza remains one of the major public health concerns because it causes annual epidemics and can potentially instigate a global pandemic. Numerous countermeasures, including vaccines and antiviral treatments, are in use against seasonal influenza ...
Rina Fajri Nuwarda, Abdulsalam Abdullah Alharbi, Veysel Kayser   +2 more
doaj   +1 more source

Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors and status of novel antivirals, 2016–2017

Antiviral Research, 2018
A total of 13672 viruses, collected by World Health Organization recognised National Influenza Centres between May 2016 and May 2017, were assessed for neuraminidase inhibitor susceptibility by four WHO Collaborating Centres for Reference and Research on
A. Lackenby, T. Besselaar, R. Daniels, A. Fry, V. Gregory, L. Gubareva, Wei-juan Huang, A. Hurt, S. Leang, R. Lee, J. Lo, L. Lollis, S. Maurer‐Stroh, T. Odagiri, D. Pereyaslov, E. Takashita, Dayan Wang, Wenqing Zhang, A. Meijer   +18 more
semanticscholar   +1 more source