Results 31 to 40 of about 53,295 (182)

Overview of Serological Techniques for Influenza Vaccine Evaluation: Past, Present and Future [PDF]

, 2014
Serological techniques commonly used to quantify influenza-specific antibodies include the Haemagglutination Inhibition (HI), Single Radial Haemolysis (SRH) and Virus Neutralization (VN) assays.
Temperton, Nigel J., Claudia Trombetta, Emanuele Montomoli, Trombetta, Claudia Maria, Stuart Mather, Perini, Daniele, Daniele Perini, Claudia Maria Trombetta, Mather, Stuart, Temperton, Nigel, Trombetta, Claudia, Nigel Temperton, Montomoli, Emanuele   +12 more
core   +1 more source

Self-amplifying mRNA bicistronic influenza vaccines raise cross-reactive immune responses in mice and prevent infection in ferrets

Molecular Therapy: Methods & Clinical Development, 2022
Vaccines are the primary intervention against influenza. Currently licensed inactivated vaccines focus immunity on viral hemagglutinin (HA). Self-amplifying mRNA (sa-mRNA) vaccines offer an opportunity to generate immunity to multiple viral proteins ...
Cheng Chang, Nedzad Music, Michael Cheung, Evan Rossignol, Sukhmani Bedi, Harsh Patel, Mohammad Safari, Changkeun Lee, Gillis R. Otten, Ethan C. Settembre, Giuseppe Palladino, Yingxia Wen   +11 more
doaj   +1 more source

Chemoenzymatic Synthesis of 6‐Sulfo Sialyl Lewisx Containing Glycans to Probe the Receptor Specificity of MERS Coronavirus

Angewandte Chemie, EarlyView.
A chemoenzymatic methodology is described that provided a panel of 6‐sulfo sialyl Lewisx‐containing glycans that were probed for receptor specificity of MERS‐CoV. Although the fucoside of 6‐sulfo‐SLex does not directly interact with the spike, it pre‐organizes the molecule into a conformation to allow a salt bridge between the sulfate and the ...
Yunfei Wu, Anne L.M. Kimpel, Jacobus P. van Trijp, Elif Uslu, Gaёl M. Vos, Luca Unione, Robert P. de Vries, Geert‐Jan Boons   +7 more
wiley   +2 more sources

Influenza Neuraminidase Inhibitors: Synthetic Approaches, Derivatives and Biological Activity

Molecules, 2016
Despite being a common viral disease, influenza has very negative consequences, causing the death of around half a million people each year. A neuraminidase located on the surface of the virus plays an important role in viral reproduction by contributing
Pedro Laborda, Su-Yan Wang, Josef Voglmeir   +2 more
doaj   +1 more source

Multidrug-Resistant Pandemic (H1N1) 2009 Infection in Immunocompetent Child

Emerging Infectious Diseases, 2011
Recent case reports describe multidrug-resistant influenza A pandemic (H1N1) 2009 virus infection in immunocompromised patients exposed to neuraminidase inhibitors because of an I223R neuraminidase mutation.
Alireza Eshaghi, Samir N. Patel, Alicia Sarabia, Rachel R. Higgins, Alexei Savchenko, Peter J. Stojios, Yan Li, Nathalie Bastien, David C. Alexander, Donald E. Low, Jonathan B. Gubbay   +10 more
doaj   +1 more source

An Overview of Influenza Viruses and Vaccines

Vaccines, 2021
Influenza remains one of the major public health concerns because it causes annual epidemics and can potentially instigate a global pandemic. Numerous countermeasures, including vaccines and antiviral treatments, are in use against seasonal influenza ...
Rina Fajri Nuwarda, Abdulsalam Abdullah Alharbi, Veysel Kayser   +2 more
doaj   +1 more source

Neuraminidase-mediated haemagglutination of recent human influenza A(H3N2) viruses is determined by arginine 150 flanking the neuraminidase catalytic site [PDF]

, 2017
Over the last decade, an increasing proportion of circulating human influenza A(H3N2) viruses exhibited haemagglutination activity that was sensitive to neuraminidase inhibitors.
Schrauwen, E.J.A. (Eefje), Vliet, S. (Stefan) van der, Beek, R. (Ruud) van, Mögling, R. (Ramona), Spronken, M.I. (Monique), Rimmelzwaan, G.F. (Guus), Fouchier, R.A.M. (Ron), Richard, M. (Mathilde), Spronken, Monique I., Rimmelzwaan, Guus F., Fouchier, Ron A.M.; id_orcid, van Beek, Ruud, Mathilde J. Richard, Schrauwen, Eefje J.A., Guus F. Rimmelzwaan, Mögling, Ramona, Eefje J. A. Schrauwen, Stefan van der Vliet, Ruud van Beek, Richard, Mathilde J.; id_orcid, Monique I. Spronken, Ron A. M. Fouchier, van der Vliet, Stefan, Ramona Mögling   +23 more
core   +3 more sources

Fc-Effector-Independent in vivo Activity of a Potent Influenza B Neuraminidase Broadly Neutralizing Antibody

Viruses, 2023
Influenza B virus (IBV) contributes to substantial influenza-mediated morbidity and mortality, particularly among children. Similar to influenza A viruses (IAV), the hemagglutinin (HA) and neuraminidase (NA) of IBV undergo antigenic drift, necessitating ...
Ahmed M. Khalil, Michael S. Piepenbrink, Ian Markham, Madhubanti Basu, Luis Martinez-Sobrido, James J. Kobie   +5 more
doaj   +1 more source

Screening for Neuraminidase Inhibitory Activity in Traditional Chinese Medicines Used to Treat Influenza

Molecules, 2016
Objective: To screen for influenza virus neuraminidase inhibition and to provide a reference for the clinical treatment of influenza using traditional Chinese medicines (TCM).
Xian-Ying Yang, Ai-lin Liu, Shu-jing Liu, Xiao-wei Xu, Lin-Fang Huang   +4 more
doaj   +1 more source

Neuraminidase construction and function

, 2022
Neuraminidase has been of interest for many years as a potential candidate for a universal influenza vaccine. This is due to the limited mutation on the head domain of the protein, specifically the active site where the enzyme lies.
Tucker, Joseph
core   +1 more source