Results 51 to 60 of about 48,869 (270)

The Elastin Receptor Complex: An Emerging Therapeutic Target Against Age-Related Vascular Diseases

Frontiers in Endocrinology, 2022
The incidence of cardiovascular diseases is increasing worldwide with the growing aging of the population. Biological aging has major influence on the vascular tree and is associated with critical changes in the morphology and function of the arterial ...
Dignê Tembely, Aubéri Henry, Laetitia Vanalderwiert, Kevin Toussaint, Amar Bennasroune, Sébastien Blaise, Hervé Sartelet, Stéphane Jaisson, Céline Galés, Laurent Martiny, Laurent Duca, Béatrice Romier-Crouzet, Pascal Maurice   +12 more
doaj   +1 more source

Neuraminidase-1 contributes significantly to the degradation of neuronal B-series gangliosides but not to the bypass of the catabolic block in Tay–Sachs mouse models

Molecular Genetics and Metabolism Reports, 2015
Tay–Sachs disease is a severe lysosomal storage disorder caused by mutations in the HEXA gene coding for α subunit of lysosomal β-Hexosaminidase A enzyme, which converts GM2 to GM3 ganglioside. HexA−/− mice, depleted of the β-Hexosaminidase A iso-enzyme,
Z.K. Timur, S. Akyildiz Demir, C. Marsching, R. Sandhoff, V. Seyrantepe   +4 more
doaj   +1 more source

Low dose influenza virus challenge in the ferret leads to increased virus shedding and greater sensitivity to oseltamivir [PDF]

, 2014
Ferrets are widely used to study human influenza virus infection. Their airway physiology and cell receptor distribution makes them ideal for the analysis of pathogenesis and virus transmission, and for testing the efficacy of anti-influenza ...
Dove, Brian K., Geoff Pearson, Kathryn A Ryan, Newman, Edmund, Wendy S Barclay, Bean, Thomas J., Carroll, Miles W., Miles W Carroll, Brian K Dove, Bassam Hallis, Edmund Newman, Easton, A. J. (Andrew J.), Marriott, Anthony C., Hallis, Bassam, Whittaker, Catherine J., Dimmock, N. J., Stuart Dowall, Silman, Nigel J., Barclay, Wendy S., Rayner, Emma, Bruce, Christine, Taylor, Irene, Jenna Plank, Andrew J Easton, Pearson, Geoff, Catherine J Whittaker, Nigel J Silman, Christine Bruce, Ryan, Kathryn A., Nigel J Dimmock, Irene Taylor, Emma Rayner, Plank, Jenna, Anthony C Marriott, Dowall, Stuart, Thomas J Bean   +35 more
core   +1 more source

Neuraminidase expressing virus-like particle vaccine provides effective cross protection against influenza virus

Virology, 2019
Neuraminidase is the second major surface antigen on influenza virus. We investigated the immunogenicity and cross protective efficacy of virus-like particle containing neuraminidase derived from 2009 pandemic H1N1 influenza virus (N1 VLP) in comparison ...
Ki-hye Kim, Young‐Tae Lee, Soojin Park, Yu-Jin Jung, Youri Lee, Eun-Ju Ko, Yu‐Jin Kim, Xuguang Li, Sang-Moo Kang   +8 more
semanticscholar   +1 more source

Influenza’s Newest Trick

mBio, 2019
Influenza A viruses are important pathogens for humans and for many birds and mammals. Hemagglutinin and neuraminidase are the major surface proteins of this enveloped RNA virus. Hemagglutinin requires proteolytic cleavage for activation, but because the
Jeffery K. Taubenberger
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Limited Hydrolysis of Polysialic Acid by Human Neuraminidase Enzymes

, 2021
Regulation of sialic acids by human neuraminidase (hNEU) enzymes is important to many biological processes. Defining hNEU substrate tolerance can help to elucidate the roles of these enzymes in regulating sialosides in human health and disease ...
Carmanah D., Hunter, Christopher, Cairo
core   +1 more source

Imprinted Anti-Hemagglutinin and Anti-Neuraminidase Antibody Responses after Childhood Infections of A(H1N1) and A(H1N1)pdm09 Influenza Viruses

mBio, 2023
Immune imprinting is a driver known to shape the anti-hemagglutinin (HA) antibody landscape of individuals born within the same birth cohort. With the HA and neuraminidase (NA) proteins evolving at different rates under immune selection pressures, anti ...
Pavithra Daulagala, Brian R. Mann, Kathy Leung, Eric H. Y. Lau, Louise Yung, Ruipeng Lei, Sarea I. N. Nizami, Joseph T. Wu, Susan S. Chiu, Rodney S. Daniels, Nicholas C. Wu, David Wentworth, Malik Peiris, Hui-Ling Yen   +13 more
doaj   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Method for evaluating the neuraminidase activity of receptor-destroying enzyme (RDE) compounds using the influenza virus

Вопросы вирусологии, 2020
Introduction. The classic hemagglutination inhibition reaction (RTGA) is used to determine the level of antiviral antibodies in human and animal serum specimens.
Artem Yu. Fedorov, Oleg P. Zhirnov
doaj   +1 more source