Results 71 to 80 of about 53,295 (182)

Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus

open access: yesmBio, 2020
Here, we investigate a monoclonal antibody, Z2B3, isolated from an H7N9-infected patient, that exhibited cross-reactivity to both N9 (group 2) and a broad range of seasonal and avian N1 (group 1) proteins but lost activity to the N1 with the substitution
Haihai Jiang   +13 more
doaj   +1 more source

Functional validation of a modified platelet desialylation test for immune and hereditary thrombocytopenias

open access: yesTransfusion Medicine, EarlyView.
Abstract Background Thrombocytopenia arises from heterogeneous inherited and acquired disorders, and identifying the underlying platelet clearance mechanisms remains challenging. Platelet desialylation, characterised by loss of sialic acid and consequent exposure of terminal β‐galactose residues recognised by the Ashwell–Morell receptor, represents an ...
Karen Nogueira Chinoca Ziza   +14 more
wiley   +1 more source

Über eine Neuraminidase in den Thrombozyten und Erythrozyten des Rindes

open access: yes, 1969
ZusammenfassungDas Homogenat lysierter Rinderthrombozyten weist eine Neuraminidase-Aktivität auf. Das Enzym ist strukturgebunden. In den Überständen nach Zentrifugation lysierter Thrombozyten fanden wir nur eine sehr geringe Neuraminidasewirkung.
W Gielen   +2 more
core   +1 more source

Neuraminidase inhibitors protect the glycocalyx.

open access: yes, 2022
Representative images and comparison of glycocalyx staining intensity in human umbilical vein endothelial cells shows that glycocalyx staining intensity is preserved when neuraminidase exposure occurs in the presence of the neuraminidase inhibitor ...
Olan Jackson-Weaver (11512962)   +9 more
core   +1 more source

Combined MS/MS-NMR Annotation Guided Discovery of Iris lactea var. chinensis Seed as a Source of Viral Neuraminidase Inhibitory Polyphenols

open access: yesMolecules, 2020
In this study, the chemical diversity of polyphenols in Iris lactea var. chinensis seeds was identified by combined MS/MS-NMR analysis. Based on the annotated chemical profile, the isolation of stilbene oligomers was conducted, and consequently, stilbene
Hyun Woo Kim   +11 more
doaj   +1 more source

TEAM: A time‐enhanced attention‐based model for virus mutation prediction

open access: yesQuantitative Biology, Volume 14, Issue 4, December 2026.
Abstract The evolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) during the coronavirus disease 2019 (COVID‐19) pandemic highlights the critical need for predicting virus mutations in order to stay ahead of infectious diseases. Here, we present the time‐enhanced attention‐based model (TEAM), which combines phylogenetic sampling ...
Jie Ji, Jie Hu, Tianwei Yu, Xiaodan Fan
wiley   +1 more source

A Novel Series of Sialic Acid-Based Influenza Virus Inhibitors that Target Influenza Virus Neuraminidase

open access: yes, 2019
Influenza virus continues to be a clinically-significant human pathogen that causes bothepidemics and pandemics. Successful inhibition of the viral neuraminidase hinders the release ofvirion progeny from the infected host cell and significantly reduces ...
Mark von Itzstein   +2 more
core   +1 more source

Antigenic Drift of the Influenza A(H1N1)pdm09 Virus Neuraminidase Results in Reduced Effectiveness of A/California/7/2009 (H1N1pdm09)-Specific Antibodies

open access: yesmBio, 2019
The effectiveness of influenza vaccines against circulating A(H1N1)pdm09 viruses was modest for several seasons despite the absence of antigenic drift of hemagglutinin (HA), the primary vaccine component. Since antibodies against HA and neuraminidase (NA)
Jin Gao   +13 more
doaj   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 41, 6 November 2026.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj   +23 more
wiley   +1 more source

neuraminidase trees global xml

open access: yes, 2014
BEAST xml file used to generate neuraminidase trees for global analysis (a single ...
Trevor Bedford (376961)   +5 more
core   +1 more source

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