Results 71 to 80 of about 52,033 (201)

Optimized production of a truncated form of the recombinant neuraminidase of influenza virus in Escherichia coli as host with suitable functional activity

Microbial Cell Factories
Background To discover effective drugs for treating Influenza (a disease with high annual mortality), large amounts of recombinant neuraminidase (NA) with suitable catalytic activity are needed. However, the functional activity of the full-length form of
Fatemeh Sadat Shariati, Fatemeh Fotouhi, Behrokh Farahmand, Zahra Barghi, Kayhan Azadmanesh   +4 more
doaj   +1 more source

In silico modeling of N294S mutation effect on the interaction of influenza virus N8 neuraminidase with zanamivir

Юг России: экология, развитие
The aim of the study is an in silico modeling of avian influenza A/H5N8 virus neuraminidase and zanamivir interaction using homology modeling and molecular docking. A/chicken/Tatarstan/88/2017 (wild type) and A/chicken/Tatarstan/112/2017 (N294S mutation)
E. A. Rukhlova, G. S. Onkhonova, M. N. Kosenko, I. M. Susloparov, I. A. Sobolev, A. B. Ryzhikov   +5 more
doaj   +1 more source

Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus

mBio, 2020
Here, we investigate a monoclonal antibody, Z2B3, isolated from an H7N9-infected patient, that exhibited cross-reactivity to both N9 (group 2) and a broad range of seasonal and avian N1 (group 1) proteins but lost activity to the N1 with the substitution
Haihai Jiang, Weiyu Peng, Jianxun Qi, Yan Chai, Hao Song, Yuhai Bi, Pramila Rijal, Haiyuan Wang, Babayemi O. Oladejo, Jinhua Liu, Yi Shi, George F. Gao, Alain R. Townsend, Yan Wu   +13 more
doaj   +1 more source

Structural Investigations and Binding Mechanisms of Oseltamivir Drug Resistance Conferred by the E119V Mutation in Influenza H7N9 Virus

Molecules, 2022
The use of vaccinations and antiviral medications have gained popularity in the therapeutic management of avian influenza H7N9 virus lately. Antiviral medicines are more popular due to being readily available. The presence of the neuraminidase protein in
Samuel C. Ugbaja, Sphamandla E. Mtambo, Aganze G. Mushebenge, Patrick Appiah-Kubi, Bahijjahtu H. Abubakar, Mthobisi L. Ntuli, Hezekiel M. Kumalo   +6 more
doaj   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Anti-neuraminidase antibodies: Which substrate should be used to test their effect on influenza virus neuraminidase

, 1981
The effect of two monoclonal anti-neuraminidase antibodies RANA 1 and WANA 1 on the enzymic activity of A/NWSHA-Tokyo/3/67NA HON2 influenza virus has been demonstrated to differ according to the substrate.
Hampson, A.W., Mountford, CE, Mountford, Carolyn E., Hampson, AW, Holmes, Kerry T., Holmes, KT   +5 more
core   +1 more source

Combined MS/MS-NMR Annotation Guided Discovery of Iris lactea var. chinensis Seed as a Source of Viral Neuraminidase Inhibitory Polyphenols

Molecules, 2020
In this study, the chemical diversity of polyphenols in Iris lactea var. chinensis seeds was identified by combined MS/MS-NMR analysis. Based on the annotated chemical profile, the isolation of stilbene oligomers was conducted, and consequently, stilbene
Hyun Woo Kim, Soo Sung Kim, Kyo Bin Kang, Byeol Ryu, Eunjin Park, Jungmoo Huh, Won Kyung Jeon, Hee-Sung Chae, Won Keun Oh, Jinwoong Kim, Sang Hyun Sung, Young-Won Chin   +11 more
doaj   +1 more source

Separating the effects of temperature and absorbed X‐ray dose on unit‐cell volume

Acta Crystallographica Section D, EarlyView.
The nature of the expansion of the crystal unit‐cell volume with absorbed dose and with temperature was examined for three different proteins.The behaviour of the unit‐cell volume of crystals of the iron‐storage molecule ferritin, both in the apo and the holo form, and of influenza A virus subtype N9 neuraminidase at 100 K and over a controlled cryo ...
Robert J. Southworth-Davies, James W. Murray, Ian Carmichael, Enrique Rudiño-Piñera, Martin Weik, Elspeth F. Garman   +5 more
wiley   +1 more source

Financial competing interests were associated with favorable conclusions and greater author productivity in nonsystematic reviews of neuraminidase inhibitors

, 2016
Objective: To characterize the conclusions and production of nonsystematic reviews about neuraminidase inhibitors relative to financial competing interests held by the authors.
Arachi, Diana, Bourgeois, Florence T., Coiera, Enrico, Hudgins, Joel, Mandl, Kenneth D., Dunn, Adam G., Zhou, Xujuan   +6 more
core   +1 more source

Hemagglutinin–Neuraminidase of Human Parainfluenza 3: Role of the Neuraminidase in the Viral Life Cycle [PDF]

, 1995
The function of neuraminidase in the life cycle and pathogenesis of human parainfluenza virus type 3 (HPF3) was studied by analyzing a variant of HPF3 that has decreased neuraminidase enzymatic activity.
HUBERMAN, KETY, MOSCONA, ANNE, PELUSO, RICHARD W.   +2 more
core   +1 more source