Results 71 to 80 of about 48,869 (270)

Supplementary Material for: ‘a’-Position-Mutated and G4-Mutated Hemagglutinin-Neuraminidase Proteins of Newcastle Disease Virus Impair Fusion and Hemagglutinin-Neuraminidase-Fusion Interaction by Different Mechanisms

, 2017
Objectives: To determine the effects of heptad repeat regions (HRs) and N-linked carbohydrate sites of the Newcastle disease virus hemagglutinin-neuraminidase (HN) protein on fusion of HN and fusion (F) proteins and HN-F interaction.
Zhang W. (2888090), Chu F. (4134397), Wen H. (4134403), Sun C. (4052647), Wang Z. (2888096), Ren G. (4052971), Song Y. (3137490), Lin B. (4134400), Zhang Y. (2828780)   +8 more
core   +1 more source

Neuraminidase inhibitors protect the glycocalyx.

, 2022
Representative images and comparison of glycocalyx staining intensity in human umbilical vein endothelial cells shows that glycocalyx staining intensity is preserved when neuraminidase exposure occurs in the presence of the neuraminidase inhibitor ...
Olan Jackson-Weaver (11512962), Chad Steele (13079), Sarah Abdullah (11512965), Juan Duchesne (11512980), Derek Pociask (11512983), Farhana Shaheen (3209685), Lauren Mueller (13982850), Brennan Gagen (8359209), Sharven Taghavi (11512959), Jay Kolls (11512986)   +9 more
core   +1 more source

Combination treatment with the cap-dependent endonuclease inhibitor baloxavir marboxil and a neuraminidase inhibitor in a mouse model of influenza A virus infection

Journal of Antimicrobial Chemotherapy, 2018
Objectives Baloxavir marboxil (formerly S-033188) is a first-in-class, orally available, cap-dependent endonuclease inhibitor licensed in Japan and the USA for the treatment of influenza virus infection.
K. Fukao, Takeshi Noshi, A. Yamamoto, Mitsutaka Kitano, Y. Ando, Takahiro Noda, Kaoru Baba, Kazumi Matsumoto, Naoko Higuchi, M. Ikeda, T. Shishido, A. Naito   +11 more
semanticscholar   +1 more source

Beyond the Biological Effect of a Chemically Characterized Poplar Propolis: Antibacterial and Antiviral Activity and Comparison with Flurbiprofen in Cytokines Release by LPS-Stimulated Human Mononuclear Cells

Biomedicines, 2019
Bee propolis, especially Euro-Asian poplar propolis, is among the most well-known natural products traditionally used to treat pharyngitis and minor wounds. The aim of this research was to investigate the pharmacological properties responsible for poplar
Paolo Governa, Maria Grazia Cusi, Vittoria Borgonetti, José Mauricio Sforcin, Chiara Terrosi, Giulia Baini, Elisabetta Miraldi, Marco Biagi   +7 more
doaj   +1 more source

A Cross-Reactive Monoclonal Antibody Against Neuraminidases of Both H9N2 and H3N2 Influenza Viruses Shows Protection in Mice Challenging Models

Frontiers in Microbiology, 2021
Neuraminidases (NAs) of H9N2 avian influenza virus (AIV) and H3N2 human seasonal influenza virus (HSIV) share similar antigenic structures. However, there are few reports on epitopes shared by these two NAs.
Fei Wang, Fei Wang, Zhimin Wan, Zhimin Wan, Zhimin Wan, Jinsen Wu, Jinsen Wu, Yajuan Wang, Yajuan Wang, Hui Fu, Hui Fu, Hongxia Shao, Hongxia Shao, Hongxia Shao, Kun Qian, Kun Qian, Kun Qian, Wei Gao, Wei Gao, Wei Gao, Jianqiang Ye, Jianqiang Ye, Jianqiang Ye, Aijian Qin, Aijian Qin, Aijian Qin   +25 more
doaj   +1 more source

Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife

Biological Reviews, EarlyView.
ABSTRACT Highly pathogenic avian influenza (HPAI) has become a critical threat to wildlife, shifting from a seasonal epizootic to a persistent, year‐round panzootic with global consequences. Here, we summarise the origin, evolutionary mechanisms, and expanding host range of the current H5N1 virus (clade 2.3.4.4b) and assess its impact on wildlife. Over
Ulrich Knief, Sandra Bouwhuis, Anja Globig, Anne Günther, Wouter Courtens   +4 more
wiley   +1 more source

Citations alone were enough to predict favorable conclusions in reviews of neuraminidase inhibitors

, 2015
Objectives To examine the use of supervised machine learning to identify biases in evidence selection and determine if citation information can predict favorable conclusions in reviews about neuraminidase inhibitors.
Tsafnat, Guy, Bourgeois, Florence T., Coiera, Enrico, Wang, Ying, Zhou, Xujuan, Dunn, Adam G.   +5 more
core   +1 more source

Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada

Emerging Infectious Diseases, 2019
We identified an influenza B isolate harboring a Gly407Ser neuraminidase substitution in an immunocompromised patient in Canada before antiviral therapy.
Yacine Abed, Clément Fage, Patrick Lagüe, Julie Carbonneau, Jesse Papenburg, Donald C. Vinh, Guy Boivin   +6 more
doaj   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Structural characterization of the carbohydrate-binding module of NanA sialidase, a pneumococcal virulence factor

, 2015
This research was supported by the University of St Andrews and grants provided by the Medical Research Council.Background: Streptococcus pneumoniae Neuraminidase A (NanA) is a multi-domain protein anchored to the bacterial surface.
Helen Connaris, Yang, Lei, Garry L. Taylor, Taylor, Garry Lindsay, Lei Yang, Potter, Jane Alexandra, Connaris, Helen, Jane A. Potter   +7 more
core   +1 more source