Results 81 to 90 of about 102,895 (315)

Influenza Neuraminidase: Underrated Role in Receptor Binding.

Trends in Microbiology, 2019
Influenza virus neuraminidase cleaves sialic acid groups from cell glycoproteins, enabling release of the virus from host cells. Neuraminidase also contributes to virus binding to the sialic acid groups of cell glycoproteins, which could complement the ...
Feng Wen, X. Wan
semanticscholar   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Neuraminidase in Bacteroides fragilis [PDF]

Applied and Environmental Microbiology, 1983
A neuraminidase from Bacteroides fragilis was purified 542-fold by isoelectric focusing, adsorption chromatography on Affi-Gel 202, and gel filtration chromatography on Sephadex G-200. On isoelectric focusing the neuraminidase was resolved into three differently charged fractions with pI values of 6.8, 7.1, and 7.4.
J O, Berg, L, Lindqvist, G, Andersson, C E, Nord   +3 more
openaire   +2 more sources

Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada

Emerging Infectious Diseases, 2019
We identified an influenza B isolate harboring a Gly407Ser neuraminidase substitution in an immunocompromised patient in Canada before antiviral therapy.
Yacine Abed, Clément Fage, Patrick Lagüe, Julie Carbonneau, Jesse Papenburg, Donald C. Vinh, Guy Boivin   +6 more
doaj   +1 more source

Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes

Nature Microbiology, 2017
A substantial proportion of influenza-related childhood deaths are due to infection with influenza B viruses, which co-circulate in the human population as two antigenically distinct lineages defined by the immunodominant receptor binding protein ...
Teddy J. Wohlbold, K. Podolsky, Veronika Chromikova, Ericka Kirkpatrick, V. Falconieri, Philip Meade, F. Amanat, Jessica Tan, B. tenOever, G. Tan, S. Subramaniam, P. Palese, F. Krammer   +12 more
semanticscholar   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Characterization of H5N1 influenza A virus that caused the first highly pathogenic avian influenza outbreak in Saudi Arabia

Journal of Infection in Developing Countries, 2015
Introduction: Saudi Arabia (SA) experienced a highly pathogenic avian influenza (HPAI) H5N1 outbreak in domesticated birds in 2007. Methodology: Forty-three hemagglutinin (HA) and 41 neuraminidase (NA) genes of HPAI H5N1 viruses were sequenced and ...
Ahmed Ali Al-Qahtani, Muhammad Mubin, Fahad N. Almajhdi, Saud Alarifi, Damian M. dela Cruz, Muhammad Shah Nawaz ul Rehman, Mahmoud Moussa Ismail, Nisar Ahmed, Mohamed H. Al-Blowi, Hanif Khalak, Mohammed N. Al-Ahdal   +10 more
doaj   +1 more source

Multiple Neuraminidase Containing Influenza Virus-like Particle Vaccines Protect Mice from Avian and Human Influenza Virus Infection

Viruses, 2022
Avian influenza virus remains a threat for humans, and vaccines preventing both avian and human influenza virus infections are needed. Since virus-like particles (VLPs) expressing single neuraminidase (NA) subtype elicited limited heterosubtypic ...
Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Min-Ju Kim, Su-Hwa Lee, Eun-Kyung Moon, Fu-Shi Quan   +8 more
doaj   +1 more source

Real time in vivo efficacy monitoring of desialylation and perforation enhanced immunotherapy of cancer

BMEMat, EarlyView.
A multifunctional nanomedicine is designed to engineer NK cells for enhanced cancer immunotherapy through perforation and desialylation, enabling real‐time monitoring of ATP and GrB levels for precise efficacy assessment. Abstract Efficient enhanced NK cell therapy is of critical importance in the immune treatment of cancer.
Yuanjiao Yang, Yuru Wang, Xuemei Li, Chaoyi Yang, Yuhui Yang, Yanyun Fang, Lin Ding, Yunlong Chen, Huangxian Ju   +8 more
wiley   +1 more source

Detection of Neuraminidase Activity in Pseudomonas aeruginosa PAO1 [PDF]

Iranian Journal of Basic Medical Sciences, 2010
Objective(s)Some properties of neuraminidase produced by Pseudomonas aeruginosa PAO1 growth in a defined medium (BHI) were examined and evaluated for its features.Materials and MethodsThe obtained supernatant enzyme of P.
Ciamak Ghazaei, Malahat Ahmadi, Nima Hosseini Jazani   +2 more
doaj