Results 81 to 90 of about 52,033 (201)

Antigenic Drift of the Influenza A(H1N1)pdm09 Virus Neuraminidase Results in Reduced Effectiveness of A/California/7/2009 (H1N1pdm09)-Specific Antibodies

mBio, 2019
The effectiveness of influenza vaccines against circulating A(H1N1)pdm09 viruses was modest for several seasons despite the absence of antigenic drift of hemagglutinin (HA), the primary vaccine component. Since antibodies against HA and neuraminidase (NA)
Jin Gao, Laura Couzens, David F. Burke, Hongquan Wan, Patrick Wilson, Matthew J. Memoli, Xiyan Xu, Ruth Harvey, Jens Wrammert, Rafi Ahmed, Jeffery K. Taubenberger, Derek J. Smith, Ron A. M. Fouchier, Maryna C. Eichelberger   +13 more
doaj   +1 more source

From haemostasis to immunity: The expanding frontiers of platelet biology

British Journal of Haematology, EarlyView.
Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley   +1 more source

Functional validation of a modified platelet desialylation test for immune and hereditary thrombocytopenias

Transfusion Medicine, EarlyView.
Abstract Background Thrombocytopenia arises from heterogeneous inherited and acquired disorders, and identifying the underlying platelet clearance mechanisms remains challenging. Platelet desialylation, characterised by loss of sialic acid and consequent exposure of terminal β‐galactose residues recognised by the Ashwell–Morell receptor, represents an ...
Karen Nogueira Chinoca Ziza, Thamy Caroline Silva, Mateus Domentino, Marina Cavalcanti Albuquerque Veiga Conrado, João Vitor Bernardo Oliveira, Felipe Augusto Rós, Caroline Gabe, Elyse Moritz, Akemi Chiba, Paula Villaça, Vanderson Rocha, Alfredo Mendrone‐Junior, José Bordin, Dante Langhi, Carla Luana Dinardo   +14 more
wiley   +1 more source

Structural studies on the sialidases from Streptococcus pneumoniae and Pseudomonas aeruginosa [PDF]

, 2009
The sialidases are a group of glycosyl hydrolases that specifically remove terminal sialic acid (Neu5Ac) residues from various glycans. In the two common human pathogenic bacteria Streptococcus pneumoniae and Pseudomonas aeruginosa, these enzymes have
Xu, Guogang
core   +2 more sources

TEAM: A time‐enhanced attention‐based model for virus mutation prediction

Quantitative Biology, Volume 14, Issue 4, December 2026.
Abstract The evolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) during the coronavirus disease 2019 (COVID‐19) pandemic highlights the critical need for predicting virus mutations in order to stay ahead of infectious diseases. Here, we present the time‐enhanced attention‐based model (TEAM), which combines phylogenetic sampling ...
Jie Ji, Jie Hu, Tianwei Yu, Xiaodan Fan
wiley   +1 more source

A comparison of two anti‐neuraminidase monoclonal antibodies by complement activation

, 1982
The specificities of two anti-neuraminidase monoclonal antibodies have been compared by their ability to fix complement. They were found to differ to some extent in their reactivity with a range of N2 influenza viruses.
Webster, Robert G., Raison, R L, Raison, Robert L., Holmes, K T, Carolyn E. Mountford, Mountford, CE, Mountford, Carolyn E., Hampson, AW, Osullivan, WJ, Raison, RL, Holmes, KT, O'Sullivan, William J., Mountford, C E, Alan W. Hampson, Hampson, A W, William J. O'Sullivan, Webster, R G, Hampson, Alan W., Webster, RG, Kerry T. Holmes, Robert L. Raison, Holmes, Kerry T., O\u27sullivan, I J, Robert G. Webster   +23 more
core   +1 more source

Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife

Biological Reviews, Volume 101, Issue 5, Page 2190-2213, October 2026.
ABSTRACT Highly pathogenic avian influenza (HPAI) has become a critical threat to wildlife, shifting from a seasonal epizootic to a persistent, year‐round panzootic with global consequences. Here, we summarise the origin, evolutionary mechanisms, and expanding host range of the current H5N1 virus (clade 2.3.4.4b) and assess its impact on wildlife. Over
Ulrich Knief, Sandra Bouwhuis, Anja Globig, Anne Günther, Wouter Courtens   +4 more
wiley   +1 more source

Protein O‐Glycosylation Shapes Lymphatic Endothelia and Lymph Node Macrophage Populations

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
To study the functional roles of O‐glycans on lymphatic endothelia, we deleted Cosmc, the chaperone required for core‐1 O‐glycan synthesis. Loss of core‐1 O‐glycans entailed major changes in glycoprotein composition of lymphatic endothelial cells (LEC), including reduced podoplanin (Pdpn), CD44, and Lyve‐1, and increased ICAM‐1; reduced CD44 was caused
Jasmin Frey, Annkathrin Ratter, Finn Brigger, Louie Cielen, Pascal Kunz, Ea Tulin, Kinga Mikos, Lothar Dieterich, Marco D'Addio, Cornelia Halin, Richard D. Cummings, Vivianne I. Otto   +11 more
wiley   +1 more source

A Novel Series of Sialic Acid-Based Influenza Virus Inhibitors that Target Influenza Virus Neuraminidase

, 2019
Influenza virus continues to be a clinically-significant human pathogen that causes bothepidemics and pandemics. Successful inhibition of the viral neuraminidase hinders the release ofvirion progeny from the infected host cell and significantly reduces ...
Mark von Itzstein, von Itzstein, Mark, von Itzstein   +2 more
core   +1 more source

Unspecific Peroxygenase‐Based Chemo‐Enzymatic Synthesis of Amino Alcohols for Pharmaceutical Preparation

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
The conversion of amines using nonspecific peroxygenases has always presented a challenge. The use of specific protecting groups, combined with the integration of enzymatic catalysis into conventional chemical methods, opens up new possibilities for the direct and enantioselective synthesis of valuable pharmaceuticals in an innovative, cost‐effective ...
Simon Last, Alina Gazizova, Katharina Wittmann, Niklas Dietz, Martin J. Weissenborn, Jan von Langermann   +5 more
wiley   +1 more source