Results 101 to 110 of about 53,295 (182)

Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses

Nature Communications
Influenza B viruses are antigenically diverse and contribute significantly to the annual influenza burden. Here we report influenza B virus neutralizing single-domain antibodies that target highly conserved regions of the hemagglutinin and neuraminidase.
Arne Matthys, Jan Felix, Joao Paulo Portela Catani, Kenny Roose, Wim Nerinckx, Benthe Van Buyten, Daria Fijalkowska, Nico Callewaert, Savvas N. Savvides, Xavier Saelens   +9 more
doaj   +1 more source

Preliminary crystallographic data for influenza virus neuraminidase "heads"

, 1978
Neuraminidase “heads” released by Pronase digestion from particles of a recombinant influenza virus (A/NWSHA—Tokyo/3/67NA, HON2) have been purified and crystallised.
Laver, W.G., Wright, Carolyn E., Laver, W. G.   +2 more
core   +1 more source

Novel Anti-Viral Properties of the Herbal Extract of Davallia mariesii against Influenza A Virus

Viruses
Gu-Sui-Bu, the dried rhizome of Davallia mariesii, is a traditional Chinese herbal remedy with a significant history of treating osteoporosis and inflammatory conditions.
Yu-Li Chen, Pei-Yu Chao, Chung-Fan Hsieh, Pei-Wen Hsieh, Jim-Tong Horng   +4 more
doaj   +1 more source

Photoaffinity labeling of the lysosomal neuraminidase from bovine testis [PDF]

, 1990
ASA-NeuAc2en, a photoreactive arylazide derivative of sialic acid, is shown to be a powerful competitive inhibitor of lysosomal neuraminidase from bovine testis (Ki ≈ 21 μM). Photoaffinity labeling and partial purification of preparations containing this
Gijsbertus T.J. van der Horst, Reinhard Brossmer, Rose, U. (Ursula), Verheijen, F.W. (Frans), Ursula Rose, Frans W. Verheijen, Horst, G.T.J. (Gijsbertus) van der, Brossmer, R. (Reinhard)   +7 more
core   +1 more source

Monitoring and Characterization of Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus, Japan, 2009–2010

Emerging Infectious Diseases, 2011
To monitor and characterize oseltamivir-resistant (OR) pandemic (H1N1) 2009 virus with the H275Y mutation, we analyzed 4,307 clinical specimens from Japan by neuraminidase (NA) sequencing or inhibition assay; 61 OR pandemic (H1N1) 2009 viruses were ...
Makoto Ujike, Miho Ejima, Akane Anraku, Kozue Shimabukuro, Masatsugu Obuchi, Noriko Kishida, Xu Hong, Emi Takashita, Seiichiro Fujisaki, Kazuyo Yamashita, Hiroshi Horikawa, Yumiko Kato, Akio Oguchi, Nobuyuki Fujita, Masato Tashiro, Takato Odagiri   +15 more
doaj   +1 more source

neuraminidase trees NC/SC/OT xml file

, 2014
neuraminidase trees NC/SC/OT xml ...
Trevor Bedford (376961), Robert J. Woods (175743), Mercedes Pascual (19597), Edward B. Baskerville (189872), Zinder, Daniel, Baskerville, Edward B., Woods, Robert J., Roy, Manojit, Manojit Roy (104218), Bedford, Trevor, Pascual, Mercedes, Daniel Zinder (106377)   +11 more
core   +1 more source

Structural characterization of the carbohydrate-binding module of NanA sialidase, a pneumococcal virulence factor [PDF]

, 2015
This research was supported by the University of St Andrews and grants provided by the Medical Research Council.Background: Streptococcus pneumoniae Neuraminidase A (NanA) is a multi-domain protein anchored to the bacterial surface.
Helen Connaris, Yang, Lei, Garry L. Taylor, Taylor, Garry Lindsay, Lei Yang, Potter, Jane Alexandra, Connaris, Helen, Jane A. Potter, Taylor, Garry Lindsay; id_orcid   +8 more
core   +1 more source

Influenza a Neuraminidase-Based Bivalent mRNA Vaccine Induces Th1-Type Immune Response and Provides Protective Effects in Mice

Vaccines
Vaccines are one of the most effective means of preventing influenza A, typically containing the hemagglutinin (HA) of the influenza A virus. However, antigenic drift and shift of the influenza A virus can lead to instability in vaccine efficacy ...
Mingyang Li, Mengyuan Liu, Shaohui Song, Ruirui Zhao, Yun Xie, Jing Liu, Lilan Xu, Xuefeng Ma, Mingyu Song, Jian Zhou, Guoyang Liao   +10 more
doaj   +1 more source

The Development of a Novel Broad-Spectrum Influenza Polypeptide Vaccine Based on Multi-Epitope Tandem Sequences

Vaccines
Background: Polypeptide vaccines have the potential to improve immune responses by targeting conserved and weakly immunogenic regions in antigens. This study aimed to identify and evaluate the efficacy of a novel influenza universal vaccine candidate ...
Song Zhao, Junhao Luo, Wenhui Guo, Li Li, Siyu Pu, Libo Dong, Wenfei Zhu, Rongbao Gao   +7 more
doaj   +1 more source

neuraminidase trees NC/SC/OT

, 2014
Neuraminidase trees generated by BEAST for NC/SC/OT analysis in NEXUS ...
Trevor Bedford (376961), Robert J. Woods (175743), Mercedes Pascual (19597), Edward B. Baskerville (189872), Zinder, Daniel, Baskerville, Edward B., Woods, Robert J., Roy, Manojit, Manojit Roy (104218), Bedford, Trevor, Pascual, Mercedes, Daniel Zinder (106377)   +11 more
core   +1 more source