Results 101 to 110 of about 48,869 (270)

Desialylation of Platelets by Pneumococcal Neuraminidase A Induces ADP-Dependent Platelet Hyperreactivity

Infection and Immunity, 2018
Platelets are increasingly recognized to play a role in the complications of Streptococcus pneumoniae infections. S. pneumoniae expresses neuraminidases, which may alter glycans on the platelet surface.
V. Kullaya, M. D. de Jonge, J. Langereis, C. E. van der Gaast-de Jongh, C. Büll, G. Adema, D. Lefeber, A. Cremers, Blandina T. Mmbaga, P. D. de Groot, Q. de Mast, A. J. van der Ven   +11 more
semanticscholar   +1 more source

Antigenic Drift of the Influenza A(H1N1)pdm09 Virus Neuraminidase Results in Reduced Effectiveness of A/California/7/2009 (H1N1pdm09)-Specific Antibodies

mBio, 2019
The effectiveness of influenza vaccines against circulating A(H1N1)pdm09 viruses was modest for several seasons despite the absence of antigenic drift of hemagglutinin (HA), the primary vaccine component. Since antibodies against HA and neuraminidase (NA)
Jin Gao, Laura Couzens, David F. Burke, Hongquan Wan, Patrick Wilson, Matthew J. Memoli, Xiyan Xu, Ruth Harvey, Jens Wrammert, Rafi Ahmed, Jeffery K. Taubenberger, Derek J. Smith, Ron A. M. Fouchier, Maryna C. Eichelberger   +13 more
doaj   +1 more source

Modular Molecular Design and Self‐Assembled Nanostructures of Saccharide‑Appended Cyclic Dipeptides for Glycosidase‑Responsive Supramolecular Hydrogels

Small, EarlyView.
Saccharide‐appended cyclic dipeptides are designed and developed as building blocks for glycosidase‐responsive supramolecular hydrogels. Their aqueous self‐assembly enables β‐galactosidase‐triggered gel‐to‐sol and neuraminidase‐triggered sol‐to‐gel transition systems, highlighting their potential as glycosidase‐responsive soft materials for biomedical ...
Shintaro Sugiura, Ryuta Tanaka, Sayuri L. Higashi, Aya Shibata, Koichiro M. Hirosawa, Kenichi G. N. Suzuki, Masato Ikeda   +6 more
wiley   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

A comparison of two anti‐neuraminidase monoclonal antibodies by complement activation

, 1982
The specificities of two anti-neuraminidase monoclonal antibodies have been compared by their ability to fix complement. They were found to differ to some extent in their reactivity with a range of N2 influenza viruses.
Webster, Robert G., Raison, R L, Raison, Robert L., Holmes, K T, Carolyn E. Mountford, Mountford, CE, Mountford, Carolyn E., Hampson, AW, Osullivan, WJ, Raison, RL, Holmes, KT, O'Sullivan, William J., Mountford, C E, Alan W. Hampson, Hampson, A W, William J. O'Sullivan, Webster, R G, Hampson, Alan W., Webster, RG, Kerry T. Holmes, Robert L. Raison, Holmes, Kerry T., O\u27sullivan, I J, Robert G. Webster   +23 more
core   +1 more source

Feathers and flu: identifying data gaps in avian influenza host dynamics to prioritize wildlife conservation Plumas y gripe: identificación de datos faltantes en la dinámica de hospedadores de la influenza aviar para priorizar la conservación de la vida silvestre

Wildlife Monographs, EarlyView.
We describe the host response continuum for highly pathogenic avian influenza viruses (HPAIV), including the continuum of host responses to HPAIV infection and exposure based on the primary axis of host competence, ability to infect other hosts, and host vulnerability.
Johanna A. Harvey, Matthew Gonnerman, Shenglai Yin, Cody M. Kent, Joshua Cullen, Jeffery D. Sullivan, Jonathan B. Dain, Nichola J. Hill, Diann J. Prosser, Jennifer M. Mullinax   +9 more
wiley   +1 more source

A Novel Series of Sialic Acid-Based Influenza Virus Inhibitors that Target Influenza Virus Neuraminidase

, 2019
Influenza virus continues to be a clinically-significant human pathogen that causes bothepidemics and pandemics. Successful inhibition of the viral neuraminidase hinders the release ofvirion progeny from the infected host cell and significantly reduces ...
Mark von Itzstein, von Itzstein, Mark, von Itzstein   +2 more
core   +1 more source

Functional validation of a modified platelet desialylation test for immune and hereditary thrombocytopenias

Transfusion Medicine, EarlyView.
Abstract Background Thrombocytopenia arises from heterogeneous inherited and acquired disorders, and identifying the underlying platelet clearance mechanisms remains challenging. Platelet desialylation, characterised by loss of sialic acid and consequent exposure of terminal β‐galactose residues recognised by the Ashwell–Morell receptor, represents an ...
Karen Nogueira Chinoca Ziza, Thamy Caroline Silva, Mateus Domentino, Marina Cavalcanti Albuquerque Veiga Conrado, João Vitor Bernardo Oliveira, Felipe Augusto Rós, Caroline Gabe, Elyse Moritz, Akemi Chiba, Paula Villaça, Vanderson Rocha, Alfredo Mendrone‐Junior, José Bordin, Dante Langhi, Carla Luana Dinardo   +14 more
wiley   +1 more source

Clinical application of a modified platelet desialylation test for mechanistic characterization of platelet transfusion refractoriness

Transfusion, EarlyView.
Abstract Background Platelet transfusion refractoriness (PTR) is a major challenge in transfusion medicine and may result from both immune and non‐immune mechanisms. Although alloantibodies are well‐established contributors, Fc‐independent pathways such as platelet desialylation have emerged as alternative mechanisms of clearance.
Karen Ziza, Thamy Silva, Mateus Domentino, Marina Conrado, João Oliveira, Elyse Moritz, Akemi Chiba, Vanderson Rocha, Alfredo Mendrone‐Junior, José Bordin, Langhi Dante, Carla Dinardo   +11 more
wiley   +1 more source

Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data

The Lancet Respiratory Medicine, 2014
Summary Background Neuraminidase inhibitors were widely used during the 2009–10 influenza A H1N1 pandemic, but evidence for their effectiveness in reducing mortality is uncertain.
S. Muthuri, S. Venkatesan, P. Myles, J. Leonardi-Bee, Tarig S A Al Khuwaitir, A. A. Al Mamun, Ashish P. Anovadiya, E. Azziz‐Baumgartner, Clarisa Báez, M. Bassetti, B. Beović, B. Bertisch, I. Bonmarin, R. Booy, V. Borja-Aburto, H. Burgmann, B. Cao, J. Carratalá, J. Denholm, S. Dominguez, P. Duarte, G. Dubnov-Raz, M. Echavarria, Sergio T. Fanella, Zhancheng Gao, P. Gérardin, M. Giannella, S. Gubbels, J. Herberg, A. H. Iglesias, P. H. Hoger, Xiao-yun Hu, Q. Islam, M. F. Jiménez, A. Kandeel, G. Keijzers, H. Khalili, M. Knight, K. Kudo, G. Kusznierz, I. Kuzman, A. Kwan, I. Amine, E. Langenegger, K. Lankarani, Y. Leo, R. Linko, Pei Liu, F. Madanat, E. Mayo-Montero, A. McGeer, Z. Memish, G. Metan, A. Mickienė, D. Mikič, K. G. Mohn, A. Moradi, P. Nymadawa, M. E. Oliva, Mehpare Ozkan, D. Parekh, M. Paul, F. Polack, B. Rath, Alejandro Rodríguez, E. B. Sarrouf, Anna C. Seale, Bunyamin Sertoğullarından, M. Siqueira, J. Skręt-Magierło, F. Stephan, Ewa Talarek, J. Tang, K. K. To, A. Torres, S. H. Törün, D. Tran, T. Uyeki, A. van Zwol, W. Vaudry, T. Vidmar, R. Yokota, P. Zarogoulidis, J. Nguyen-Van-Tam   +83 more
semanticscholar   +1 more source