Influenza virus neuraminidase (NA) of the N9 subtype also possesses hemagglutinin activity and the hemagglutinating, or hemabsorbing (HB), site is distinct from the catalytic site.
Air, Gillian M., Laver, W.Graeme
core +1 more source
Molecular dynamics and free energy analysis of neuraminidase-ligand interactions
We report molecular dynamics calculations of neuraminidase in complex with an inhibitor, 4-amino-2-deoxy-2,3-didehydro-N-acetylneuraminic acid (N-DANA), with subsequent free energy analysis of binding by using a combined molecular mechanics/continuum ...
Bonnet, Pascal +3 more
core +1 more source
This image illustrates the induction of protective antibodies against influenza neuraminidase (NA) protein by seasonal vaccination (syringe). The dynamic flow of light symbolizes the vaccination procedure.
Wang, Yiquan
core
Antiviral Susceptibility of Clade 2.3.4.4b H5N1 and H5N5 Influenza Viruses Detected in Birds in Russia During 2021-2022. [PDF]
Svyatchenko SV +9 more
europepmc +1 more source
Susceptibility of human neural stem cells to SARS-CoV-2: Entry mechanisms and glycocalyx influence. [PDF]
Song A, Zuvia C, Talbot P.
europepmc +1 more source
Computational antiviral drug design
This study designed and computational docked a group of ligands intended to find potent inhibitors for Neuraminidase 4 which would have strong interactions with 8 conserved amino acids in the active site. Several trials of ligands were designed based on
Liu, Lishan
core
Emergence and spread of NA-I223V and NA-S247N double-mutant A(H1N1)pdm09 influenza viruses with reduced oseltamivir susceptibility in the Netherlands and beyond, 2023 to 2026. [PDF]
Felix Garza Z +11 more
europepmc +1 more source
Antiviral Activity of the Polyene Macrolide Roseofungin Against Influenza a Virus: In Vitro, In Ovo, and Preliminary In Vivo Evaluation. [PDF]
Bogoyavlenskiy A +9 more
europepmc +1 more source
Broadly reactive antibodies against influenza B virus hemagglutinin neutralize and protect through distinct structural mechanisms. [PDF]
Bhavsar D +5 more
europepmc +1 more source
Signal mining of adverse reactions for neuraminidase inhibitors in pregnant women: a disproportionality analysis based on the FDA adverse event reporting system database. [PDF]
Cao B, Shen M, Du C, Song Q, Ma Z.
europepmc +1 more source

