Results 91 to 100 of about 102,895 (315)

Peripheral nerve repair: a hot spot analysis on treatment methods from 2010 to 2014

Neural Regeneration Research, 2015
Therapeutic strategies for neurological deficits and for promoting nerve regeneration after peripheral nerve injuries have received much focus in clinical research.
Guang-yao Liu, Yan Jin, Qiao Zhang, Rui Li   +3 more
doaj   +1 more source

Influenza Viruses: Harnessing the Crucial Role of the M2 Ion-Channel and Neuraminidase toward Inhibitor Design

Molecules, 2021
As a member of the Orthomyxoviridae family of viruses, influenza viruses (IVs) are known causative agents of respiratory infection in vertebrates. They remain a major global threat responsible for the most virulent diseases and global pandemics in humans.
Sphamadla E. Mtambo, Daniel G. Amoako, Anou M. Somboro, Clement Agoni, Monsurat M. Lawal, Nelisiwe S. Gumede, Rene B. Khan, Hezekiel M. Kumalo   +7 more
doaj   +1 more source

Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection [PDF]

, 2017
The emergence of multiple novel lineages of H1 and H3 influenza A viruses in swine has confounded control by inactivated vaccines. Because of substantial genetic and geographic heterogeneity among circulating swine influenza viruses, one vaccine strain ...
Claes, Gerwin, Cox, Eric, Krammer, Florian, Mancera Gracia, José Carlos, Qiu, Yu, Sys, Lieve, Trus, Ivan, Van Reeth, Kristien, Versnaeyen, Han   +8 more
core   +2 more sources

Docking study of flavonoid derivatives as potent inhibitors of influenza H1N1 virus neuraminidase.

Biomedical Reports, 2018
Influenza type A is considered as a severe public health concern. The mechanism of drugs applied for the control of this virus depends on two surface glycoproteins with antigenic properties, namely hemagglutinin (HA) and neuraminidase (NA).
S. M. Sadati, N. Gheibi, Saeed Ranjbar, M. Hashemzadeh   +3 more
semanticscholar   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus

mBio, 2020
Here, we investigate a monoclonal antibody, Z2B3, isolated from an H7N9-infected patient, that exhibited cross-reactivity to both N9 (group 2) and a broad range of seasonal and avian N1 (group 1) proteins but lost activity to the N1 with the substitution
Haihai Jiang, Weiyu Peng, Jianxun Qi, Yan Chai, Hao Song, Yuhai Bi, Pramila Rijal, Haiyuan Wang, Babayemi O. Oladejo, Jinhua Liu, Yi Shi, George F. Gao, Alain R. Townsend, Yan Wu   +13 more
doaj   +1 more source

Structural Investigations and Binding Mechanisms of Oseltamivir Drug Resistance Conferred by the E119V Mutation in Influenza H7N9 Virus

Molecules, 2022
The use of vaccinations and antiviral medications have gained popularity in the therapeutic management of avian influenza H7N9 virus lately. Antiviral medicines are more popular due to being readily available. The presence of the neuraminidase protein in
Samuel C. Ugbaja, Sphamandla E. Mtambo, Aganze G. Mushebenge, Patrick Appiah-Kubi, Bahijjahtu H. Abubakar, Mthobisi L. Ntuli, Hezekiel M. Kumalo   +6 more
doaj   +1 more source

Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase

Journal of Immunology, 2017
Activated microglia can phagocytose dying, stressed, or excess neurons and synapses via the phagocytic receptor Mer tyrosine kinase (MerTK). Galectin-3 (Gal-3) can cross-link surface glycoproteins by binding galactose residues that are normally hidden ...
K. Nomura, A. Vilalta, David H Allendorf, Tamara C. Hornik, Guy C. Brown   +4 more
semanticscholar   +1 more source

What happened after the epidemic? Equine influenza surveillance sheds light on sources and seasonal risk in the United Kingdom

Equine Veterinary Journal, EarlyView.
Abstract Background The epidemiology of equine influenza (EI) in the United Kingdom has not been systematically described since the 2019 epidemic. Objectives To summarise UK EI surveillance (2020–2024), quantify outbreak seasonality and assess movement‐related sources. Study Design Retrospective observational analysis of national surveillance and horse
Fleur Whitlock, John Grewar, Richard Newton   +2 more
wiley   +1 more source

In silico modeling of N294S mutation effect on the interaction of influenza virus N8 neuraminidase with zanamivir

Юг России: экология, развитие
The aim of the study is an in silico modeling of avian influenza A/H5N8 virus neuraminidase and zanamivir interaction using homology modeling and molecular docking. A/chicken/Tatarstan/88/2017 (wild type) and A/chicken/Tatarstan/112/2017 (N294S mutation)
E. A. Rukhlova, G. S. Onkhonova, M. N. Kosenko, I. M. Susloparov, I. A. Sobolev, A. B. Ryzhikov   +5 more
doaj   +1 more source