Substantial Antigenic Drift in the Hemagglutinin Protein of Swine Influenza A Viruses [PDF]
Viruses, 2020 The degree of antigenic drift in swine influenza A viruses (swIAV) has historically been regarded as minimal compared to that of human influenza A virus strains.
Pia Ryt-Hansen +6 more
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The emergence of new antigen branches of H9N2 avian influenza virus in China due to antigenic drift on hemagglutinin through antibody escape at immunodominant sites [PDF]
Emerging Microbes and Infections, 2023 Vaccination is a crucial prevention and control measure against H9N2 avian influenza viruses (AIVs) that threaten poultry production and public health.
Nan Zhang +11 more
doaj +4 more sources
Antigenic drift: Understanding COVID-19 [PDF]
Immunity, 2021 Antigenic drift refers to the evolutionary accumulation of amino acid substitutions in viral proteins selected by host adaptive immune systems as the virus circulates in a population. Antigenic drift can substantially limit the duration of immunity conferred by infection and vaccination.
Jonathan W Yewdell
exaly +5 more sources
Antigenic drift and epidemiological severity of seasonal influenza in Canada [PDF]
Scientific Reports, 2022 Seasonal influenza epidemics circulate globally every year with varying levels of severity. One of the major drivers of this seasonal variation is thought to be the antigenic drift of influenza viruses, resulting from the accumulation of mutations in ...
Zishu Chen +3 more
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The molecular determinants of antigenic drift in a novel avian influenza A (H9N2) variant virus [PDF]
Virology Journal, 2022 Background In early 2020, a novel H9N2 AIV immune escape variant emerged in South China and rapidly spread throughout mainland China. The effectiveness of the current H9N2 vaccine is being challenged by emerging immune escape strains. Assessing key amino
Yiqing Zheng +7 more
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Vaccination and antigenic drift in influenza [PDF]
Vaccine, 2008 The relationship between influenza antigenic drift and vaccination lies at the intersection of evolutionary biology and public health, and it must be viewed and analyzed in both contexts simultaneously. In this paper, 1 review what is known about the effects of antigenic drift on vaccination and the effects of vaccination on antigenic drift, and I ...
Maciej F Boni
exaly +3 more sources
Machine Learning Prediction and Experimental Validation of Antigenic Drift in H3 Influenza A Viruses in Swine [PDF]
mSphere, 2021 Influenza A viruses (IAV) in swine constitute a major economic burden to an important global agricultural sector, impact food security, and are a public health threat.
Michael A. Zeller +5 more
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mBio, 2019 The effectiveness of influenza vaccines against circulating A(H1N1)pdm09 viruses was modest for several seasons despite the absence of antigenic drift of hemagglutinin (HA), the primary vaccine component. Since antibodies against HA and neuraminidase (NA)
Jin Gao +13 more
doaj +3 more sources
Changed epitopes drive the antigenic drift for influenza A (H3N2) viruses [PDF]
BMC Bioinformatics, 2011 Background In circulating influenza viruses, gradually accumulated mutations on the glycoprotein hemagglutinin (HA), which interacts with infectivity-neutralizing antibodies, lead to the escape of immune system (called antigenic drift).
Yang Jinn-Moon, Huang Jhang-Wei
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Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States [PDF]
eLifeInfluenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected individuals, but the
Amanda C Perofsky +25 more
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