Results 1 to 10 of about 123,103 (291)

Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation [PDF]

eLife, 2016
Survival of Trypanosoma brucei depends upon switches in its protective Variant Surface Glycoprotein (VSG) coat by antigenic variation. VSG switching occurs by frequent homologous recombination, which is thought to require locus-specific initiation. Here,
Rebecca Devlin, Catarina A Marques, Daniel Paape, Marko Prorocic, Andrea C Zurita-Leal, Samantha J Campbell, Craig Lapsley, Nicholas Dickens, Richard McCulloch   +8 more
doaj   +4 more sources

Exploring antigenic variation in autoimmune endocrinopathy [PDF]

Frontiers in Immunology
Autoimmune disorders develop owing to a misdirected immune response against self-antigen. Genetic studies have revealed that numerous variants in genes encoding immune system proteins are associated with the development of autoimmunity.
Maria Mavridou, Simon H. Pearce, Simon H. Pearce   +2 more
doaj   +2 more sources

Bioinformatics and Structural Analysis of Antigenic Variation in the Hemagglutinin Gene of the Influenza A(H1N1)pdm09 Virus Circulating in Shiraz (2013 to 2015) [PDF]

Microbiology Spectrum, 2023
Circulating influenza A virus provided an excellent opportunity to study the adaptation of the influenza A(H1N1)pdm09 virus to the human host. Particularly, due to the availability of sequences taken from isolates, we could monitor amino acid changes and
Mojtaba Mortazavi, Neda Pirbonyeh, Fatemeh Javanmardi, Amir Emami   +3 more
doaj   +2 more sources

Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei [PDF]

mBio, 2022
In the mammalian host, Trypanosoma brucei is coated in a single-variant surface glycoprotein (VSG) species. Stochastic switching of the expressed VSG allows the parasite to escape detection by the host immune system.
Emilia Jane McLaughlin, Karinna Rubio-Pena, Annick Dujeancourt-Henry, Lucy Glover   +3 more
doaj   +2 more sources

A droplet digital PCR assay to measure pilin antigenic variation frequency in Neisseria gonorrhoeae [PDF]

mSphere
The strict human pathogen Neisseria gonorrhoeae (gonococcus [Gc]) infects an estimated 82 million individuals globally and is a World Health Organization-designated bacterial pathogen of public health importance due to escalating antimicrobial resistance.
Sarah J. Quillin, Di Luo, Aoife Gavagan, Arthur Prindle, H Steven Seifert   +4 more
doaj   +2 more sources

A DOT1B/Ribonuclease H2 Protein Complex Is Involved in R-Loop Processing, Genomic Integrity, and Antigenic Variation in Trypanosoma brucei [PDF]

mBio, 2021
The parasite Trypanosoma brucei periodically changes the expression of protective variant surface glycoproteins (VSGs) to evade its host’s immune system in a process known as antigenic variation.
Nicole Eisenhuth, Tim Vellmer, Elisa T. Rauh, Falk Butter, Christian J. Janzen   +4 more
doaj   +2 more sources

Borrelia miyamotoi in vivo antigenic variation demonstrated by serotype reisolations from infected mice [PDF]

Infection and Immunity
Relapsing fever Borrelia (RFB) employs antigenic variation to alter its surface protein structure in response to host immune pressure. This process occurs by the single translocation of archived variable major protein (Vmp) pseudogenes into a vmp ...
Brittany A. Armstrong, Kevin S. Brandt, Robert D. Gilmore   +2 more
doaj   +2 more sources

DNA double strand break position leads to distinct gene expression changes and regulates VSG switching pathway choice.

PLoS Pathogens, 2021
Antigenic variation is an immune evasion strategy used by Trypanosoma brucei that results in the periodic exchange of the surface protein coat. This process is facilitated by the movement of variant surface glycoprotein genes in or out of a specialized ...
Alix Thivolle, Ann-Kathrin Mehnert, Eliane Tihon, Emilia McLaughlin, Annick Dujeancourt-Henry, Lucy Glover   +5 more
doaj   +1 more source

Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune system [PDF]

, 2020
Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Magez, Stefan, Obishakin, Emmanuel Tumininu, Pinto Torres, Joar Esteban, Radwanska, Magdalena   +3 more
core   +1 more source

The use of high-throughput DNA sequencing in the investigation of antigenic variation: application to Neisseria species. [PDF]

PLoS ONE, 2014
Antigenic variation occurs in a broad range of species. This process resembles gene conversion in that variant DNA is unidirectionally transferred from partial gene copies (or silent loci) into an expression locus. Previous studies of antigenic variation
John K Davies, Paul F Harrison, Ya-Hsun Lin, Stephanie Bartley, Chen Ai Khoo, Torsten Seemann, Catherine S Ryan, Charlene M Kahler, Stuart A Hill   +8 more
doaj   +1 more source