Results 31 to 40 of about 2,182,609 (246)

Dengue genetic divergence generates within-serotype antigenic variation, but serotypes dominate evolutionary dynamics

eLife, 2019
Dengue virus (DENV) exists as four genetically distinct serotypes, each of which is historically assumed to be antigenically uniform. Recent analyses suggest that antigenic heterogeneity may exist within each serotype, but its source, extent and impact ...
Sidney M Bell, Leah Katzelnick, Trevor Bedford   +2 more
doaj   +1 more source

Evolution of Host Specificity by Malaria Parasites through Altered Mechanisms Controlling Genome Maintenance

mBio, 2020
The protozoan parasites that cause malaria infect a wide variety of vertebrate hosts, including birds, reptiles, and mammals, and the evolutionary pressures inherent to the host-parasite relationship have profoundly shaped the genomes of both host and ...
Michelle C. Siao, Janus Borner, Susan L. Perkins, Kirk W. Deitsch, Laura A. Kirkman   +4 more
doaj   +1 more source

Sequence-based prediction for vaccine strain selection and identification of antigenic variability in foot-and-mouth disease virus [PDF]

, 2010
Identifying when past exposure to an infectious disease will protect against newly emerging strains is central to understanding the spread and the severity of epidemics, but the prediction of viral cross-protection remains an important unsolved problem ...
Reeve Richard, de Beer, T.A.P., Hester G O'Neill, Daniel T Haydon, O'Neill, H.G., Matthews, L., Opperman, Pamela, Belinda Blignaut, Esterhuysen, Jan J., Richard Reeve, Maree, F.F., Hester G. O'Neill, Tjaart A P de Beer, Haydon, Daniel Thomas, De Beer, Tjaart, Maree, Francois Frederick, Tjaart A. P. de Beer, Maree Francois F., Jacques Theron, Reeve, R., O'Neill Hester G., Opperman, Pamela Anne, Rieder, Elizabeth, Theron, Jacques, Elizabeth Rieder, Haydon, D.T., Blignaut Belinda, Blignaut, B., Matthews Louise, Rieder Elizabeth, Theron, J., Maree, Francois, Haydon Daniel T., Blignaut, Belinda, Opperman, P., Vosloo, W., Louise Matthews, Reeve, Richard, Elizabeth E. Fry, O'Neill, Hester Gertruida, de Beer Tjaart A. P., Pamela Opperman, Jan J. Esterhuysen, Francois F Maree, Haydon, Daniel, Fry, E.E., Elizabeth E Fry, Wilna Vosloo, Fry, Elizabeth E., Vosloo, Wilna, Vosloo Wilna, Daniel T. Haydon, O’Neill, Hester G., Esterhuysen, J.J., Opperman Pamela, Matthews, Louise, De Beer, T.A.P. (Tjaart Andries Petrus), Esterhuysen Jan J., Esterhuysen, Jan, Francois F. Maree, Theron Jacques, Rieder, E., Jan J Esterhuysen, Fry Elizabeth E., Fry, Elizabeth   +64 more
core   +1 more source

Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation

eLife, 2016
Survival of Trypanosoma brucei depends upon switches in its protective Variant Surface Glycoprotein (VSG) coat by antigenic variation. VSG switching occurs by frequent homologous recombination, which is thought to require locus-specific initiation. Here,
Rebecca Devlin, Catarina A Marques, Daniel Paape, Marko Prorocic, Andrea C Zurita-Leal, Samantha J Campbell, Craig Lapsley, Nicholas Dickens, Richard McCulloch   +8 more
doaj   +1 more source

Interference of infectious bursal disease virus on antibody production against Newcastle disease and infectious bronchitis virus

Brazilian Journal of Poultry Science, 2006
This work has the objective of verifying the interference of infectious bursal disease virus in the antibody production against Newcastle disease virus and infectious bronchitis virus.
WM Cardoso, JLC Aguiar Filho, JM Romão, RPR Salles, SR Câmara, AA Siqueira, WF Oliveira, MHNR Sobral, RSC Texeira   +8 more
doaj   +1 more source

Regulation of Antigenic Variation in Giardia lamblia [PDF]

, 2011
Antigenic variation, a clonal phenotypic variation developed by microorganisms, involves the permanent switching of homologous, antigenically different cell surface molecules.
Hugo D. Luján, Fernando D. Rivero, Lujan, Hugo Daniel, César G. Prucca, Rivero, Fernando David, Prucca, Cesar German   +5 more
core   +1 more source

Rapid turnover of Plasmodium falciparum var gene transcripts and genotypes during natural non-symptomatic infections Rápida mudança de transcritos var e de génotipos de Plasmodium falciparum em infecções assintomáticas naturalmente adquiridas

Revista do Instituto de Medicina Tropical de São Paulo, 2005
The var genes of Plasmodium falciparum code for the antigenically variant erythrocyte membrane proteins 1 (PfEMP1), a major factor for cytoadherence and immune escape of the parasite.
Gerhard Wunderlich, Fabiana P. Alves, Uta Gölnitz, Mauro S. Tada, Erney F.P. de Camargo, Luiz H. Pereira-da-Silva   +5 more
doaj   +1 more source

Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance. [PDF]

PLoS ONE, 2011
Drugs inhibiting the influenza A virus (IAV) neuraminidase (NA) are the cornerstone of anti-IAV chemotherapy and prophylaxis in man. Drug-resistant mutations in NA arise frequently in human isolates, limiting the therapeutic application of NA inhibitors.
Scott E Hensley, Suman R Das, James S Gibbs, Adam L Bailey, Loren M Schmidt, Jack R Bennink, Jonathan W Yewdell   +6 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source