Results 11 to 20 of about 63,337 (255)
Antigenic Variation in Vector-Borne Pathogens
Emerging Infectious Diseases, 2000 Several pathogens of humans and domestic animals depend on hematophagous arthropods to transmit them from one vertebrate reservoir host to another and maintain them in an environment.
Alan G. Barbour, Blanca I. Restrepo
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Mini-review: Strategies for Variation and Evolution of Bacterial Antigens
Computational and Structural Biotechnology Journal, 2015 Across the eubacteria, antigenic variation has emerged as a strategy to evade host immunity. However, phenotypic variation in some of these antigens also allows the bacteria to exploit variable host niches as well.
Janet Foley
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mSphere, 2019 Gene diversification is a common mechanism pathogens use to alter surface structures to aid in immune avoidance. Neisseria gonorrhoeae uses a gene conversion-based diversification system to alter the primary sequence of the gene encoding the major ...
Egon A. Ozer +5 more
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Cross-Reactive Antibody Responses against Nonpoliovirus Enteroviruses
mBio, 2022 Enteroviruses are among the most common human viral pathogens. Infection with members of a subgroup of viruses within this genus, the nonpoliovirus enteroviruses (NPEVs), can result in a broad spectrum of serious illnesses, including acute flaccid ...
Amy B. Rosenfeld +5 more
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Mosaic VSGs and the scale of Trypanosoma brucei antigenic variation.
PLoS Pathogens, 2013 A main determinant of prolonged Trypanosoma brucei infection and transmission and success of the parasite is the interplay between host acquired immunity and antigenic variation of the parasite variant surface glycoprotein (VSG) coat.
James P J Hall +2 more
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mBio, 2018 Genomic analysis reveals extensive sequence variation and hot spots of recombination in surface proteins of Streptococcus pneumoniae. While this phenomenon is commonly attributed to diversifying selection by host immune responses, there is little ...
M. Georgieva +4 more
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eLife, 2019 Dengue virus (DENV) exists as four genetically distinct serotypes, each of which is historically assumed to be antigenically uniform. Recent analyses suggest that antigenic heterogeneity may exist within each serotype, but its source, extent and impact ...
Sidney M Bell +2 more
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Phase and Antigenic Variation In Mycoplasmas
Future Microbiology, 2010 With their reduced genome bound by a single membrane, bacteria of the Mycoplasma species represent some of the simplest autonomous life forms. Yet, these minute prokaryotes are able to establish persistent infection in a wide range of hosts, even in the presence of a specific immune response.
Citti, Christine +2 more
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mBio, 2020 The protozoan parasites that cause malaria infect a wide variety of vertebrate hosts, including birds, reptiles, and mammals, and the evolutionary pressures inherent to the host-parasite relationship have profoundly shaped the genomes of both host and ...
Michelle C. Siao +4 more
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eLife, 2016 Survival of Trypanosoma brucei depends upon switches in its protective Variant Surface Glycoprotein (VSG) coat by antigenic variation. VSG switching occurs by frequent homologous recombination, which is thought to require locus-specific initiation. Here,
Rebecca Devlin +8 more
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