Results 11 to 20 of about 2,182,609 (246)
Antigenic Variation in Vector-Borne Pathogens [PDF]
Emerging Infectious Diseases, 2000 Several pathogens of humans and domestic animals depend on hematophagous arthropods to transmit them from one vertebrate reservoir host to another and maintain them in an environment.
Alan G. Barbour, Blanca I. Restrepo
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A histone methyltransferase modulates antigenic variation in African trypanosomes. [PDF]
PLoS Biology, 2008 To evade the host immune system, several pathogens periodically change their cell-surface epitopes. In the African trypanosomes, antigenic variation is achieved by tightly regulating the expression of a multigene family encoding a large repertoire of ...
Luisa M Figueiredo +2 more
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Mosaic VSGs and the scale of Trypanosoma brucei antigenic variation. [PDF]
PLoS Pathogens, 2013 A main determinant of prolonged Trypanosoma brucei infection and transmission and success of the parasite is the interplay between host acquired immunity and antigenic variation of the parasite variant surface glycoprotein (VSG) coat.
James P J Hall +2 more
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Mechanisms Mediating Antigenic Variation in Trypanosoma brucei
Memorias do Instituto Oswaldo Cruz, 1999 Antigenic variation in Trypanosoma brucei is a highly sophisticated survival strategy involving switching between the transcription of one of an estimated thousand variant surface glycoprotein (VSG) genes.
Rudenko Gloria
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Antigenic variation in Trypanosoma brucei: joining the DOTs. [PDF]
PLoS Biology, 2008 African trypanosomes, such as <i>Trypanosoma brucei</i>, are protistan parasites that cause sleeping sickness. Though first described more than a century ago, trypanosomes remain a blight on the health of the human population and on the ...
Chris Stockdale +3 more
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Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes' repertoires. [PDF]
Nat Commun, 2023 Surface antigenic variation is crucial for major pathogens that infect humans. To escape the immune system, they exploit various mechanisms. Understanding these mechanisms is important to better prevent and fight the deadly diseases caused. Those used by
Meier CS +8 more
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Antigenic variation in African trypanosomes [PDF]
, 2014 Studies on Variant Surface Glycoproteins (VSGs) and antigenic variation in the African trypanosome, Trypanosoma brucei, have yielded a remarkable range of novel and important insights. The features first identified in T.
Horn, David; id_orcid
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mSphere, 2019 Gene diversification is a common mechanism pathogens use to alter surface structures to aid in immune avoidance. Neisseria gonorrhoeae uses a gene conversion-based diversification system to alter the primary sequence of the gene encoding the major ...
Egon A. Ozer +5 more
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DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. [PDF]
, 2013 Antigenic variation in African trypanosomes requires monoallelic transcription and switching of variant surface glycoprotein (VSG) genes. The transcribed VSG, always flanked by '70 bp'-repeats and telomeric-repeats, is either replaced through DNA double ...
Glover, Lucy +12 more
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Mini-review: Strategies for Variation and Evolution of Bacterial Antigens
Computational and Structural Biotechnology Journal, 2015 Across the eubacteria, antigenic variation has emerged as a strategy to evade host immunity. However, phenotypic variation in some of these antigens also allows the bacteria to exploit variable host niches as well.
Janet Foley
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