Results 21 to 30 of about 2,182,609 (246)

Cross-Reactive Antibody Responses against Nonpoliovirus Enteroviruses

mBio, 2022
Enteroviruses are among the most common human viral pathogens. Infection with members of a subgroup of viruses within this genus, the nonpoliovirus enteroviruses (NPEVs), can result in a broad spectrum of serious illnesses, including acute flaccid ...
Amy B. Rosenfeld, Edmund Qian Long Shen, Michaela Melendez, Nischay Mishra, W. Ian Lipkin, Vincent R. Racaniello   +5 more
doaj   +1 more source

Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity [PDF]

, 2009
Antigenic variation is an immune evasion strategy that has evolved in viral, bacterial and protistan pathogens. In the African trypanosome this involves stochastic switches in the composition of a variant surface glycoprotein (VSG) coat, using a massive ...
Marcello, Lucio, McCulloch, Richard, R Mcculloch, Morrison, Liam J., L Marcello, L J Morrison   +5 more
core   +1 more source

Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species [PDF]

, 2012
Antigenic variation enables pathogens to avoid the host immune response by continual switching of surface proteins. The protozoan blood parasite Trypanosoma brucei causes human African trypanosomiasis ("sleeping sickness") across sub-Saharan Africa and ...
Browne, H., Jackson, Andrew P., Marcello, Lucio, Jackson, A.P., Jackson, A. P., Quail, M. A., Marcello, L., Quail, M.A., Berriman, Matthew, Jackson, Andrew P, Berry, Andrew, Field, M. C., Aslett, Martin, Sanders, Mandy J., McQuillan, J., Barry, J. David, Field, Mark C., Allinson, Harriet C., Browne, Hilary, Hauser, H., Aslett, M., Barry, J.D., Burton, Peter, Allison, Harriet C., Ginger, Michael L., Gilderthorp, Ruth, Berry, A., van Tonder, Andries, Allison, H.C., McQuillan, Jacqueline, Burton, P., Ginger, M.L., Corton, Nicola, Gilderthorp, R., Hertz-Fowler, Christiane, Field, M.C., Field, MarkC., Corton, N., Quail, Michael A., Gamble, John, Brown, R., Otto, Thomas D., Otto, T. D., Barry, J. D., Gamble, J., Hauser, Heidi, Hertz-Fowler, C., Brown, Robert, van Tonder, A., Berriman, M., Ginger, Michael, Vavrova-Anderson, Jana, Vavrova-Anderson, J., Sanders, M.J., Allison, H. C., Hertz-Fowler, Christine, Otto, T.D., Sanders, M. J.   +57 more
core   +1 more source

Genome hyperevolution and the success of a parasite [PDF]

, 2012
The strategy of antigenic variation is to present a constantly changing population phenotype that enhances parasite transmission, through evasion of immunity arising within, or existing between, host animals.
J. David Barry, Hall, J.P.J., Plenderleith, L., James P. J. Hall, Barry, J.D., Lindsey Plenderleith   +5 more
core   +1 more source

Phase and antigenic variation in mycoplasmas [PDF]

, 2010
With their reduced genome bound by a single membrane, bacteria of the Mycoplasma species represent some of the simplest autonomous life forms. Yet, these minute prokaryotes are able to establish persistent infection in a wide range of hosts, even in the ...
Nouvel, Laurent-Xavier, Christine Citti, Laurent-Xavier Nouvel, Eric Baranowski, Citti, Christine, Baranowski, Eric, Nouvel, Lx   +6 more
core   +1 more source

Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variation [PDF]

, 2005
In Trypanosoma brucei, DNA recombination is crucial in antigenic variation, a strategy for evading the mammalian host immune system found in a wide variety of pathogens.
Proudfoot, C, McCulloch, Richard, Proudfoot, Christopher, McCulloch, R   +3 more
core   +1 more source

Antigenic Variation in Streptococcus pneumoniae PspC Promotes Immune Escape in the Presence of Variant-Specific Immunity

mBio, 2018
Genomic analysis reveals extensive sequence variation and hot spots of recombination in surface proteins of Streptococcus pneumoniae. While this phenomenon is commonly attributed to diversifying selection by host immune responses, there is little ...
M. Georgieva, L. Kagedan, Ying-Jie Lu, C. M. Thompson, M. Lipsitch   +4 more
doaj   +1 more source

Molecular mechanisms underlying the control of antigenic variation in African trypanosomes [PDF]

, 2010
African trypanosomes escape the host adaptive immune response by switching their dense protective coat of Variant Surface Glycoprotein (VSG). Each cell expresses only one VSG gene at a time from a telomeric expression site (ES).
Horn, David, McCulloch, Richard, Horn, David; id_orcid, David Horn, Richard McCulloch   +4 more
core   +1 more source

Antigenic variation in pathogenic micro-organisms: similarities and differences

, 2007
Antigenic variation is a process by which pathogenic micro-organisms escape the immune response of their mammalian hosts. By convergent evolution, protozoal, fungal and bacterial pathogens have developed similar genetic mechanisms for true antigenic ...
Steverding, D
core   +5 more sources

Antigenic drift in H5N1 avian influenza virus in poultry is driven by mutations in major antigenic sites of the hemagglutinin molecule analogous to those for human influenza virus [PDF]

, 2011
H5N1 highly pathogenic avian influenza virus has been endemic in poultry in Egypt since 2008, notwithstanding the implementation of mass vaccination and culling of infected birds.
Arafa, Abdel, Temperton, Nigel J., Giovanni Cattoli, Alessandra Buratin, Mona Meherez Aly, Adelaide Milani, Cattoli, Giovanni, Milani, Adelaide, Zecchin, Bianca, Ilaria Capua, Capua, Ilaria, Eleonora Molesti, Bianca Zecchin, Abdel Arafa, Buratin, Alessandra, Aly, Mona Meherez, Temperton, Nigel, Meherez Aly, Mona, Nigel Temperton, Molesti, Eleonora   +19 more
core   +1 more source