Results 21 to 30 of about 123,103 (291)

Canalization of the evolutionary trajectory of the human influenza virus [PDF]

, 2011
Since its emergence in 1968, influenza A (H3N2) has evolved extensively in genotype and antigenic phenotype. Antigenic evolution occurs in the context of a two-dimensional 'antigenic map', while genetic evolution shows a characteristic ladder-like ...
A Kucharski, A Monto, A Park, A Rambaut, Andrew Rambaut, B Adams, B Finkelman, C Viboud, CA Russell, D Weinreich, DJ Smith, E Goldstein, E O'Dea, E Volz, F Carrat, F Tria, G Chowell, G Hirst, IG Barr, J Gog, J Lin, J O'Brien, J Truscott, J Voeten, K Koelle, K Koelle, K Koelle, K Koelle, M Recker, Mercedes Pascual, MI Nelson, NM Ferguson, R Bush, S Bhatt, S Gould, S Kryazhimskiy, S Park, T Bedford, T Bedford, Trevor Bedford, V Gupta, WM Fitch, YI Wolf, Z Yang   +43 more
core   +5 more sources

Antigenic Variation in Streptococcus pneumoniae PspC Promotes Immune Escape in the Presence of Variant-Specific Immunity

mBio, 2018
Genomic analysis reveals extensive sequence variation and hot spots of recombination in surface proteins of Streptococcus pneumoniae. While this phenomenon is commonly attributed to diversifying selection by host immune responses, there is little ...
M. Georgieva, L. Kagedan, Ying-Jie Lu, C. M. Thompson, M. Lipsitch   +4 more
doaj   +1 more source

Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation. [PDF]

, 2013
Spatial relationships within the eukaryotic nucleus are essential for proper nuclear function. In Plasmodium falciparum, the repositioning of chromosomes has been implicated in the regulation of the expression of genes responsible for antigenic variation,
Berriman, Matthew, Eastman, Richard T., Feller, Avi I., Kyes, Sue A., Lemieux, Jacob E., Newbold, Chris I., Otto, Thomas D., Pinches, Robert A., Su, Xin-Zhuan   +8 more
core   +1 more source

Spirochetal Lipoproteins and Immune Evasion. [PDF]

, 2017
Spirochetes are a major threat to public health. However, the exact pathogenesis of spirochetal diseases remains unclear. Spirochetes express lipoproteins that often determine the cross talk between the host and spirochetes.
Boyadjian, Ani, Christodoulides, Alexei, Kelesidis, Theodoros   +2 more
core   +1 more source

Dengue genetic divergence generates within-serotype antigenic variation, but serotypes dominate evolutionary dynamics

eLife, 2019
Dengue virus (DENV) exists as four genetically distinct serotypes, each of which is historically assumed to be antigenically uniform. Recent analyses suggest that antigenic heterogeneity may exist within each serotype, but its source, extent and impact ...
Sidney M Bell, Leah Katzelnick, Trevor Bedford   +2 more
doaj   +1 more source

Integrating influenza antigenic dynamics with molecular evolution. [PDF]

, 2013
Influenza viruses undergo continual antigenic evolution allowing mutant viruses to evade host immunity acquired to previous virus strains. Antigenic phenotype is often assessed through pairwise measurement of cross-reactivity between influenza strains ...
Abed, Ansaldi, Ansaldi, Barr, Barr, Bedford, Bedford, Bogner, Borodin, Cai, Centers for Disease Control and Prevention, Chakraverty, Chakraverty, Cox, Cox, Daniels, Daum, Daum, Donatelli, Drummond, Edgar, Ferguson, Fitch, Gog, Goldstein, Gust, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hensley, Hirst, Kanegae, Kendal, Klimov, Koel, Lemey, Li, Lin, Lin, Lin, Lin, Matsuzaki, McCauley, McCauley, McCauley, McCauley, McCauley, McDonald, Muyanga, Nakagawa, Nakajima, Nakajima, Nakajima, Nelson, Nerome, Oh, Osterholm, Pagel, Pereira, Puzelli, Pybus, Raymond, Rota, Russell, Shapiro, Shaw, Smith, Squires, Stevens, Webster, Wiley, World Health Organization, Xu   +83 more
core   +4 more sources

Evolution of Host Specificity by Malaria Parasites through Altered Mechanisms Controlling Genome Maintenance

mBio, 2020
The protozoan parasites that cause malaria infect a wide variety of vertebrate hosts, including birds, reptiles, and mammals, and the evolutionary pressures inherent to the host-parasite relationship have profoundly shaped the genomes of both host and ...
Michelle C. Siao, Janus Borner, Susan L. Perkins, Kirk W. Deitsch, Laura A. Kirkman   +4 more
doaj   +1 more source

Recent advances in malaria genomics and epigenomics [PDF]

, 2016
Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian, Power, B. Joanne, Waters, Andrew P.   +2 more
core   +1 more source

The effects of symmetry on the dynamics of antigenic variation

, 2012
In the studies of dynamics of pathogens and their interactions with a host immune system, an important role is played by the structure of antigenic variants associated with a pathogen.
A Fässler, A Marcello, B Adams, B Fiedler, C Jones, C Newbold, C Stockdale, CA Pinto, CMR Turner, CO Buckee, CO Buckee, DG Aronson, DJ Smith, DL Martin, H Farkas, I Stewart, IM Rouzine, JD Barry, JD Murray, JHP Dawes, JL Mitchell, JL Muñoz-Jordán, JR Gog, JW Swift, KA Lythgoe, KB Blyuss, Konstantin B. Blyuss, KW Deitsch, LJ Abu-Raddad, LM Pecora, M Dellnitz, M Golubitsky, M Golubitsky, M Golubitsky, M Golubitsky, M Recker, M Recker, M Recker, M Recker, M Recker, MGM Gomes, MJ Gardner, O Bagasra, P Ashwin, P Ashwin, P Borst, P De Leenheer, P Hagblom, P Minaev, PL Buono, R Antia, S Gupta, S Gupta, S Gupta, S Kyes, S Lutenschlager, SA Frank, SA Frank, SH Strogatz, V Calvez, Y Jiang, Z Agur   +61 more
core   +1 more source

Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes [PDF]

, 1990
The metacyclic form of African trypanosomes is the first to express genes for the Variant Surface Glycoprotein (VSG) and it uses an unusually predictable subset of the VSG gene repertoire.
Barry, J D, Graham, S V, Matthews, K R, Shiels, P G   +3 more
core   +1 more source