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Identification of peptide mimotopes of Trypanosoma brucei gambiense variant surface glycoproteins. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: The current antibody detection tests for the diagnosis of gambiense human African trypanosomiasis (HAT) are based on native variant surface glycoproteins (VSGs) of Trypanosoma brucei (T.b.) gambiense.
Liesbeth Carolien Van Nieuwenhove, Stijn Rogé, Fatima Balharbi, Tessa Dieltjens, Thierry Laurent, Yves Guisez, Philippe Büscher, Veerle Lejon   +7 more
doaj   +6 more sources

Identification of mimotopes with diagnostic potential for Trypanosoma brucei gambiense variant surface glycoproteins using human antibody fractions. [PDF]

PLoS Neglected Tropical Diseases, 2012
BACKGROUND: At present, screening of the population at risk for gambiense human African trypanosomiasis (HAT) is based on detection of antibodies against native variant surface glycoproteins (VSGs) of Trypanosoma brucei (T.b.) gambiense.
Liesbeth Van Nieuwenhove, Philippe Büscher, Fatima Balharbi, Michael Humbert, Tessa Dieltjens, Yves Guisez, Veerle Lejon   +6 more
doaj   +2 more sources

Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity. [PDF]

PLoS Neglected Tropical Diseases, 2015
Trypanosoma brucei variant surface glycoproteins (VSG) are glycosylated by both paucimannose and oligomannose structures which are involved in the formation of a protective barrier against the immune system.
Víctor M Castillo-Acosta, Luis M Ruiz-Pérez, Els J M Van Damme, Jan Balzarini, Dolores González-Pacanowska   +4 more
doaj   +6 more sources

Control of Variant Surface Glycoprotein Expression by CFB2 in Trypanosoma brucei and Quantitative Proteomic Connections to Translation and Cytokinesis

mSphere, 2022
Variant surface glycoproteins (VSGs) coat parasitic African trypanosomes and underpin antigenic variation and immune evasion. These VSGs are superabundant virulence factors that are subject to posttranscriptional gene expression controls mediated via the
Gustavo Bravo Ruiz, Michele Tinti, Melanie Ridgway, David Horn   +3 more
doaj   +2 more sources

The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei. [PDF]

Gene, 1980
We have isolated poly(A)+ RNA from four antigenic variants (117, 118, 121, 221) of one clone of Trypanosoma brucei. Translation of these poly(A)+ RNAs in a rabbit reticulocyte lysate gave rise to proteins that could be precipitated with antisera against ...
Borst, P. (Piet), Burg, J. van den, Cross, G.A.M., Hoeijmakers, J.H.J. (Jan), Weissmann, C.   +4 more
core   +3 more sources

Variant surface glycoproteins from Venezuelan trypanosome isolates are recognized by sera from animals infected with either Trypanosoma evansi or Trypanosoma vivax [PDF]

Veterinary parasitology, 2014
Salivarian trypanosomes sequentially express only one variant surface glycoprotein (VSG) on their cell surface from a large repertoire of VSG genes. Seven cryopreserved animal trypanosome isolates known as TeAp-ElFrio01, TEVA1 (or TeAp-N/D1), TeGu-N/D1 ...
Acosta Serrano, Alvaro
core   +2 more sources

Evaluation of the diagnostic accuracy of prototype rapid tests for human African trypanosomiasis [PDF]

, 2014
Peer reviewedPublisher ...
A Agresti, A Garcia, C Burri, D Malvy, E Hasker, F Chappuis, GA Posthuma-Trumpie, Jayne Raper, Jeremy M. Sternberg, JM Sternberg, Joseph M. Ndung'u, JR Landis, K Ziegelbauer, L Sullivan, L Sullivan, Marek Gierliński, Michael A. J. Ferguson, MP Barrett, N VanMeirvenne, P Buscher, P Buscher, P Dukes, P Mitashi, P Mitashi, PG Kennedy, PP Simarro, RW Peeling, SL Wastling, Sylvain Biéler   +28 more
core   +20 more sources

Dynamic, variable oligomerization and the trafficking of variant surface glycoproteins of Trypanosoma brucei

Traffic : the International Journal of Intracellular Transport, 2021
African trypanosomes cause disease in humans and livestock, avoiding host immunity by changing the expression of variant surface glycoproteins (VSGs); the major glycosylphosphatidylinositol (GPI) anchored antigens coating the surface of the bloodstream ...
Khan Umaer, Francisco Aresta-Branco, M. Chandra, Monique van Straaten, J. Zeelen, K. Lapouge, Brandon Waxman, C. E. Stebbins, J. Bangs   +8 more
semanticscholar   +1 more source

Visualisation of experimentally determined and predicted protein N-glycosylation and predicted glycosylphosphatidylinositol anchor addition in Trypanosoma brucei. [version 1; peer review: 3 approved]

Wellcome Open Research, 2022
Background: Trypanosoma brucei is a protozoan parasite and the etiological agent of human and animal African trypanosomiasis. The organism cycles between its mammalian host and tsetse vector.
Michael A. J. Ferguson, Michele Tinti
doaj   +1 more source

Identifying Antigenic Switching by Clonal Cell Barcoding and Nanopore Sequencing in Trypanosoma brucei

Bio-Protocol, 2023
Many organisms alternate the expression of genes from large gene sets or gene families to adapt to environmental cues or immune pressure. The single-celled protozoan pathogen Trypanosoma brucei spp.
Abdoulie Touray, Tamara Sternlieb, Tony Isebe, Igor Cestari   +3 more
doaj   +1 more source