Results 31 to 40 of about 2,071 (159)

Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes [PDF]

, 1990
The metacyclic form of African trypanosomes is the first to express genes for the Variant Surface Glycoprotein (VSG) and it uses an unusually predictable subset of the VSG gene repertoire.
Matthews, K R; id_orcid, Graham, S V, Shiels, P G, Barry, J D   +3 more
core   +1 more source

Genetic exchange in Trypanosoma brucei: evidence for mating prior to metacyclic stage development [PDF]

, 2005
It is well established that genetic exchange occurs between Trypanosoma brucei parasites when two stocks are used to infect tsetse flies under laboratory conditions and a number of such crosses have been undertaken.
Turner, C.M.R., Tait, A., Tweedie, A., Masiga, D., MacLeod, A.   +4 more
core   +1 more source

Structural Studies of Variant Surface Glycoproteins on the Trypanosoma Surface [PDF]

, 2021
Trypanosoma parasites are the pathogenic agent causing human and animal African Trypanosomiasis. The parasites undergo a process called antigenic variation, which allows them to perpetually evade the host immune response.
Hempelmann, Alexander
core   +1 more source

Characterization of Trypanosoma brucei gambiense variant surface glycoprotein LiTat 1.5

, 2012
At present, all available diagnostic antibody detection tests for Trypanosoma brucei gambiense human African trypanosomiasis are based on predominant variant surface glycoproteins (VSGs), such as VSG LiTat 1.5. During investigations aiming at replacement
Rogé, S., Lejon, V., Guisez, Y., Guisez, Yves, Van Nieuwenhove, L., Büscher, P., Rog\ue9, S.   +6 more
core   +1 more source

Trypanosoma Variant Surface Glycoprotein: A Review

مجلة الانبار للعلوم البيطرية
The glycoprotein surface of the Trypanosoma parasite plays a crucial role in the organism’s biology, as a protective barrier that facility invasion to the host.
Kalef, Dalia Ahmed, Shather, Maulood M
doaj   +1 more source

Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei

BMC Genomics, 2009
Background Trypanosoma brucei, the causative agent of African sleeping sickness, undergoes a complex developmental cycle that takes place in mammalian and insect hosts and is accompanied by changes in metabolism and cellular morphology. While differences
Kifer Charles T, Sivam Dhileep, Jensen Bryan C, Myler Peter J, Parsons Marilyn   +4 more
doaj   +1 more source

Digital gene expression analysis of two life cycle stages of the human-infective parasite, Trypanosoma brucei gambiense reveals differentially expressed clusters of co-regulated genes

BMC Genomics, 2010
Background The evolutionarily ancient parasite, Trypanosoma brucei, is unusual in that the majority of its genes are regulated post-transcriptionally, leading to the suggestion that transcript abundance of most genes does not vary significantly between ...
Wildridge David, Terry Sandra, Trivedi Urmi, Johnson Paul CD, Veitch Nicola J, MacLeod Annette   +5 more
doaj   +1 more source

Blocking Variant Surface Glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation

, 2009
Background: The African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream.
Gluenz, E, Rudenko, G, Gluenz Eva, Terry K Smith, Shulamit Michaeli, Susanne Kramer, Michaeli, Shulamit, Terry, Stephen, Terry K. Smith, Michaeli, S, Eva Gluenz, Smith, Terry K., Vasileva, N, Nadina Vasileva, Mark Carrington, Michaeli Shulamit, Vasileva, Nadina, Carrington, M, Stephen Terry, Rudenko Gloria, Gull Keith, Portman, N, Gluenz, Eva, Keith Gull, Terry, S, Smith Terry K., Neil Portman, Gull, K, Kramer, S, Portman, Neil, Smith, TK, Smith, Terry K, Rudenko, Gloria, Terry Stephen, Vasileva Nadina, Gull, Keith, Carrington Mark, Carrington, Mark, Kramer, Susanne, Terry K. Smith, Portman Neil, Kramer Susanne, Gloria Rudenko   +42 more
core   +1 more source

A novel selection regime for differentiation defects demonstrates an essential role for the stumpy form in the life cycle of the African trypanosome [PDF]

, 2000
A novel selection scheme has been developed to isolate bloodstream forms of Trypanosoma brucei, which are defective in their ability to differentiate to the procyclic stage.
Wilson, J, Matthews, K; id_orcid, Tasker, M, Hendriks, E, Sarkar, M   +4 more
core   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source