Expression of Trypanosoma brucei gambiense Antigens in Leishmania tarentolae. Potential for Use in Rapid Serodiagnostic Tests (RDTs). [PDF]
PLoS Neglected Tropical Diseases, 2015 The development of rapid serodiagnostic tests for sleeping sickness and other diseases caused by kinetoplastids relies on the affordable production of parasite-specific recombinant antigens.
Barrie Rooney +4 more
doaj +1 more source
African Trypanosomes undermine humoral responses and vaccine development : link with inflammatory responses? [PDF]
, 2017 African trypanosomosis is a debilitating disease of great medical and socioeconomical importance. It is caused by strictly extracellular protozoan parasites capable of infecting all vertebrate classes including human, livestock, and game animals.
Achcar +160 more
core +1 more source
Control of variant surface glycoprotein gene-expression sites in Trypanosoma brucei [PDF]
The EMBO Journal, 1999 Trypanosoma brucei has 20 similar telomeric-expression sites for variant surface glycoprotein genes. Expression sites appear to be controlled at the level of transcription initiation, resulting in only one site being active at any time. Switching between expression sites occurs at a low rate.
I, Chaves +4 more
openaire +2 more sources
Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human African trypanosomiasis. [PDF]
PLoS Neglected Tropical Diseases, 2014 The diagnosis of human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). There is no immunodiagnostic for HAT caused by T. b. rhodesiense.
Lauren Sullivan +5 more
doaj +1 more source
Secretory pathway of trypanosomatid parasites [PDF]
, 2002 The Trypanosomatidae comprise a large group of parasitic protozoa, some of which cause important diseases in humans. These include Tryanosoma brucei (the causative agent of African sleeping sickness and nagana in cattle), Trypanosoma cruzi (the causative
McConville, Malcolm J. +3 more
core +1 more source
Journal of Biological Chemistry, 1986 The variant surface glycoproteins (VSGs) of Trypanosoma brucei are synthesized with a hydrophobic COOH-terminal peptide that is cleaved and replaced by a glycophospholipid, which anchors VSG to the surface membrane.
M. Ferguson +4 more
semanticscholar +1 more source
Intracellular transport of a variant surface glycoprotein in Trypanosoma brucei. [PDF]
The Journal of cell biology, 1988 Trypanosome variant surface glycoproteins (VSGs) have a novel glycan-phosphatidylinositol membrane anchor, which is cleavable by a phosphatidylinositol-specific phospholipase C. A similar structure serves to anchor some membrane proteins in mammalian cells.
Duszenko, Michael +4 more
openaire +3 more sources
Insight into the exoproteome of the tissue-derived trypomastigote form of trypanosoma cruzi [PDF]
, 2016 The protozoan parasite Trypanosoma cruzi causes Chagas disease, one of the major neglected infectious diseases. It has the potential to infect any nucleated mammalian cell. The secreted/excreted protein repertoire released by T.
Bastos, Izabela M D +7 more
core +3 more sources
Synchronous expression of individual metacyclic variant surface glycoprotein genes in Trypanosoma brucei [PDF]
Molecular and Biochemical Parasitology, 2015 One distinctive feature of the Trypanosoma brucei life cycle is the presence of two discrete populations that are based on differential expression of variant surface glycoproteins (VSGs). Both are adapted to the environmental pressures they face and more importantly, both contribute directly to transmission.
Kiantra, Ramey-Butler +3 more
openaire +2 more sources
Adaptation and therapeutic exploitation of the plasma membrane of African trypanosomes [PDF]
, 2018 African trypanosomes are highly divergent from their metazoan hosts, and as part of adaptation to a parasitic life style have developed a unique endomembrane system.
Canavate Del Pino, Ricardo +4 more
core +3 more sources