Results 41 to 50 of about 2,071 (159)

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors : toward the development of novel therapies for African sleeping sickness [PDF]

, 2010
Trypanosoma brucei, the causative agent of human African trypanosomiasis, affects tens of thousands of sub-Saharan Africans. As current therapeutics are inadequate due to toxic side effects, drug resistance, and limited effectiveness, novel therapies are
Michael A. J. Ferguson, Durrant, Jacob D., Ferguson, Michael A. J., Jacob D. Durrant, Ferguson, Michael A. J.; id_orcid, Michael D. Urbaniak, McCammon, J. Andrew, Urbaniak, Michael D., J. Andrew McCammon   +8 more
core   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, Volume 65, Issue 22, 25 May 2026.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei [PDF]

, 2013
African trypanosomes are sustained in the bloodstream of their mammalian hosts by their extreme capacity for antigenic variation. However, for life cycle progression, trypanosomes also must generate transmission stages called stumpy forms that are pre ...
Szoor, Balazs; id_orcid, Matthews, KR, Binny M. Mony, Keith Roland Matthews, Paula MacGregor, Paula eMacGregor, Mony, BM, Mony, B, Balazs eSzoor, Macgregor, Paula, Matthews, Keith R; id_orcid, MacGregor, P, Matthews, K, Mony, Binny M, Balazs Szoor, Rojas, Federico, Rico, Eva, Keith R. Matthews, Eva eRico, Rojas, F, Eva Rico, Federico Rojas, Szoor, B, Federico eRojas, Binny M Mony, Rico, E   +25 more
core   +1 more source

Field observations on the use of rapid diagnostic tests for Human African Trypanosomiasis in Nigeria

Frontiers in Tropical Diseases
IntroductionHuman African Trypanosomiasis (HAT) is a Neglected Tropical Disease targeted for elimination by 2030. Control efforts have reduced prevalence, but diagnostic challenges for field surveillance persist.
Chinwe U. Chukwudi, Chinwe U. Chukwudi, Omolara S. Adenekan, Jonadab C. Chinwendu, Amadea O. Enwonwu, Chinonso C. Iyi, Uchenna H. Anyaorah, Chukwuebuka V. Ugwu, Michael O. John, Glory N. Joseph, Akwoba J. Ogugua, Akwoba J. Ogugua, Silva M. Anika   +12 more
doaj   +1 more source

Trypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity.

PLoS ONE, 2013
Trypanosoma brucei gambiense infection is widely considered an anthroponosis, although it has also been found in wild and domestic animals. Thus, fauna could act as reservoir, constraining the elimination of the parasite in hypo-endemic foci.
Carlos Cordon-Obras, Jorge Cano, Dolores González-Pacanowska, Agustin Benito, Miguel Navarro, Jean-Mathieu Bart   +5 more
doaj   +1 more source

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source

Chromosome-wide analysis of gene function by RNA interference in the african trypanosome. [PDF]

, 2006
Trypanosomatids of the order Kinetoplastida are major contributors to global disease and morbidity, and understanding their basic biology coupled with the development of new drug targets represents a critical need.
J. Hayes-Sinclair, Subramaniam, C, Chambers, E, Field, Mark C, Shawcross, Emma, D. Horn, Carrington, M, Hayes-Sinclair, Jamie, Field, Mark C., K. Gull, Redmond, S, P. Veazey, Matthews, K, Horn, David, E. Chambers, Redmond, Seth, Matthews, Keith; id_orcid, Veazey, P, Veazey, Paul, M. Carrington, S. Redmond, Field, MC, Gull, K, Horn, D, Subramaniam, Chandra, Horn, David; id_orcid, C. Subramaniam, Hayes-Sinclair, J, K. Matthews, Gull, Keith, Chambers, Emma, Carrington, Mark, M. C. Field, Matthews, Keith   +33 more
core   +1 more source

Bacterial Extracellular Vesicles in Biomedical Research and Clinical Translation

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Bacterial membrane vesicle biomedical applications. ABSTRACT Bacterial Extracellular Vesicles (bEVs) are lipid (single‐ or double‐bilayer) nanostructures secreted by virtually all bacteria that play fundamental roles in intercellular communication and have emerged as powerful, multifunctional tools in biomedicine. Their intrinsic ability to encapsulate
Alejandro Arce‐Rodríguez, Javier De la Peña Noya, José Manuel Borrero‐de Acuña   +2 more
wiley   +1 more source

Telomeric expression sites are highly conserved in trypanosoma brucei [PDF]

, 2008
Subtelomeric regions are often under-represented in genome sequences of eukaryotes. One of the best known examples of the use of telomere proximity for adaptive purposes are the bloodstream expression sites (BESs) of the African trypanosome Trypanosoma ...
J. E. Taylor (6065927), Rosanna Young, Kartvelishvili Magdalena, Kartvelishvili, M., Paul Heath, I. Goodhead (7668314), Quail, M.A., Saunders David, Saunders, D., Goodhead, Ian, H. Hauser (7684433), Walker, Danielle, Hauser, H., Rudenko Gloria, Becker, M., Andrew Jackson, Ian Goodhead, Sanders, M., Jesse E Taylor, Seeger Kathy, K. Seeger (7684442), Nathalie Bason, Figueiredo, Luisa M, Young Rosanna, D. Saunders (7684439), J David Barry, Fahkro, Samah, B. White (5926835), L. M. Figueiredo (7684409), S. Fahkro (7684421), Jackson, Andrew, Barry J. David, Cross George A. M., Louis Edward J., C. Churcher (7684418), D. Harris (3507287), J. D. Barry (7684448), Louis, Edward J, Jackson, A., David Saunders, Luisa M Figueiredo, M. Sanders (7684436), Sharp Sarah, Walker Danielle, G. Rudenko (7669793), Goodhead, I., Brooks Karen, Hertz-Fowler, C., Quail, Michael A, Heidi Hauser, Kathy Seeger, A. Jackson (7323707), Carol Churcher, Edward J Louis, Churcher, Carol, Louis, E.J., Fahkro, S., M. Becker (7669790), George A M Cross, Jackson Andrew, Churcher Carol, Becker, Marion, Hertz-Fowler Christiane, Seeger, K., Taylor, Jesse E, Bason, N., Sanders Mandy, Marion Becker, White, Brian, Taylor, J.E., M. Kartvelishvili (7684427), K. Brooks (7684415), R. Young (7646078), Berriman, Matthew, Young, R., Edward John Louis (7604981), Harris, D., Brooks, Karen, Heath Paul, M. A. Quail (7633010), Figueiredo Luisa M., Bason Nathalie, Samah Fahkro, David Harris, Mungall Karen, Barry, J.D., Barry, J David, Quail Michael A., Brooks, K., Churcher, C., Sanders, Mandy, Bason, Nathalie, Rudenko, Gloria, Heath, P., Goodhead Ian, Magdalena Kartvelishvili, Fahkro Samah, Hauser Heidi, Gloria Rudenko, Berriman Matthew, Hertz-Fowler, Christiane, G. A. Cross (7684445), D. Walker (1668601), Cross, G.A M, Becker Marion, K. Mungall (7684430), Figueiredo, L.M., Danielle Walker, Sharp, Sarah, Sharp, S., Karen Brooks, Saunders, David, Taylor Jesse E., P. Heath (7684424), Mungall, K., Brian White, Kartvelishvili, Magdalena, Hauser, Heidi, Seeger, Kathy, C. Hertz-Fowler (7684406), S. Sharp (7639394), N. Bason (7684412), Cross, George AM, Walker, D., Mandy Sanders, Michael A Quail, White, B., Berriman, M., Young, Rosanna, Harris David, Mungall, Karen, Rudenko, G., Christiane Hertz-Fowler, Karen Mungall, Matthew Berriman, M. Berriman (7684451), Harris, David, Heath, Paul, Sarah Sharp, White Brian   +139 more
core   +1 more source